DDR1-IN-6 - ≥98% , CAS No.2416021-47-9

CAS: 2416021-47-9 Cat. No.: D649135 Summenformel: C₂₃H₁₄F₃N₅O Molekulargewicht: 433.39

GRADE & PURITY ≥98%

Storage

Store at 2-8°C,Protected from light,Desiccated

Shipped In

Wet ice

Übersicht

DDR1-IN-6 is a selective Discoidin Domain Receptor family, member 1 (DDR1) inhibitor with an IC 50 of 9.72 nM. DDR1-IN-6 inhibits auto-phosphorylation DDR1b (Y513) with an IC 50 of 9.7 nM. DDR1-IN-6 has anti-cancer activity

In Vitro

DDR1-IN-6 (compound 1; for 24 hours) inhibits collagen production in human hepatic stellate cell LX-2 (IC 50 =13 nM). DDR1-IN-6 (72 hours) has cytotoxicity in LX-2 cells (CC 50 =3 μM). DDR1-IN-6 (0-30 μM) has anti-proliferation effects on primary tumor cells freshly isolated from PC-07-0024 (IC 50 =5.7 μM of 3 days; IC 50 =2.65 μM of 6 days) and LU-01-0523 derived xenograft (PDX) tumor model (IC 50 >30 μM of 3 days; IC 50 >30 μM of 6 days). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:DDR1 9.72 nM (IC 50 )

Specifications

Spezifikationen & Reinheit

≥98%

Biochemische und physiologische Mechanismen

DDR1-IN-6 is a selective Discoidin Domain Receptor family, member 1 (DDR1) inhibitor with an IC 50 of 9.72 nM. DDR1-IN-6 inhibits auto-phosphorylation DDR1b (Y513) with an IC 50 of 9.7 nM. DDR1-IN-6 has anti-cancer activity.

Storage

Store at 2-8°C,Protected from light,Desiccated

Verschickt in

Wet ice

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

INHIBITOR

Reinheit

≥98%

Namen und Kennungen

Molekulargewicht

433.39

Chemische und physikalische Eigenschaften

• Löslichkeit: DMSO : 10 mg/mL (23.07 mM; Need ultrasonic)