[Des-Arg9]-Bradykinin acetate - ≥99% , CAS No.23827-91-0

CAS: 23827-91-0 Cat. No.: B648794 Molecular Weight: 964.07 PubChem CID: 134821694

GRADE & PURITY ≥99%

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

[Des-Arg9]-Bradykinin acetate is a Bradykinin B 1 receptor agonist that displays selectivity for B 1 over B 2 receptors.

In Vitro

[Des-Arg9]-Bradykinin acetate is a Bradykinin(B 1 ) receptor agonist. The B 2 receptor mediates the action of bradykinin (BK) and lysyl-bradykinin (Lys-BK), the first set of bioactive kinins formed in response to injury from kininogen precursors through the actions of plasma and tissue kallikreins, whereas the B 1 receptor mediates the action of [Des-Arg 9 ]-Bradykinin (des-Arg 9 -BK) and Lys-des-Arg Arg 9 -BK, the second set of bioactive kinins formed through the actions of carboxypeptidases on BK and Lys-BK, respectively. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:Bradykinin B 1 receptor

Specifications

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

[Des-Arg9]-Bradykinin acetate is a Bradykinin B 1 receptor agonist that displays selectivity for B 1 over B 2 receptors.

Storage

Desiccated, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥99%

Names and Identifiers

• Canonical Smiles: CC(=O)O.C1CC(N(C1)C(=O)C2CCCN2C(=O)C(CCCN=C(N)N)N)C(=O)NCC(=O)NC(CC3=CC=CC=C3)C(=O)NC(CO)C(=O)N4CCCC4C(=O)NC(CC5=CC=CC=C5)C(=O)O
• IUPAC Name: acetic acid;(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[2-[[(2S)-1-[(2S)-1-[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]pyrrolidine-2-carbonyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-3-hydroxypropanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid
• InChIKey: FLNJLMIOGWOIQM-NHJGMUSQSA-N
• INCHI: 1S/C44H61N11O10.C2H4O2/c45-29(15-7-19-48-44(46)47)40(61)55-22-10-18-35(55)42(63)54-21-8-16-33(54)38(59)49-25-36(57)50-30(23-27-11-3-1-4-12-27)37(58)52-32(26-56)41(62)53-20-9-17-34(53)39(60)51-31(43(64)65)24-28-13-5-2-6-14-28;1-2(3)4/h1-6,11-14,29-35,56H,7-10,15-26,45H2,(H,49,59)(H,50,57)(H,51,60)(H,52,58)(H,64,65)(H4,46,47,48);1H3,(H,3,4)/t29-,30-,31-,32-,33-,34-,35-;/m0./s1
• PubChem CID: 134821694
• Molecular Weight: 964.07

Chemical and Physical Properties

• Solubility: H2O : 100 mg/mL (103.73 mM; Need ultrasonic)