Dicyclohexylmethane 4,4'-Diisocyanate (mixture of isomers)(HMDI) - ≥90%(GC) , CAS No.5124-30-1

CAS: 5124-30-1 Cat. No.: D155475 Molecular Weight: 262.35 EC Number: 225-863-2
AVAILABLE TO ORDER
GRADE & PURITY ≥90%(GC)
Synonyms
HMDI | AKOS000120188 | Cyclohexane, 1,1'-methylenebis[4-isocyanato-, (trans,trans)- | D2380 | SCHEMBL8733246 | TRANS-TRANS-METHYLENEBIS(4-CYCLOHEXYLISOCYANATE) | Isocyanic acid, methylenedi-4,1-cyclohexylene ester, cis,cis- | 4,4'-Diisocyanatodicyclohexyl
Storage
Store at 2-8°C,Argon charged
Shipped In
Wet ice
 ·  off list, applied to all prices below.
Size
Status
Price
Qty
5g
D155475-5g
2
$9.90
25g
D155475-25g
2
$18.90
100g
D155475-100g
3
$41.90
500g
D155475-500g
9
$107.90
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Why this grade

≥90%(GC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at 2-8°C,Argon charged Ships Wet ice Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 60 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

4,4′-Methylenebis(cyclohexyl isocyanate), mixture of isomers (HMDI) is an aromatic diisocyanate with good mechanical properties. It is light stable and is resistant to hydrolysis. It is majorly used in the synthesis of polyurethane.
Application
HMDI forms NCO linkages which can be used in the synthesis of polyurethanes for a variety of biomedical applications.

Specifications

Synonyms
HMDI | AKOS000120188 | Cyclohexane, 1, 1'-methylenebis[4-isocyanato-, (trans, trans)- | D2380 | SCHEMBL8733246 | TRANS-TRANS-METHYLENEBIS(4-CYCLOHEXYLISOCYANATE) | Isocyanic acid, methylenedi-4, 1-cyclohexylene ester, cis, cis- | 4, 4'-Diisocyanatodicyclohexyl
Specifications & Purity
≥90%(GC)
Storage
Store at 2-8°C, Argon charged
Shipped In
Wet ice
This product requires cold chain shipping. Ground and other economy services are not available.
Purity
≥90%(GC)
Names and Identifiers
Canonical SmilesC1CC(CCC1CC2CCC(CC2)N=C=O)N=C=O
IUPAC Name1-isocyanato-4-[(4-isocyanatocyclohexyl)methyl]cyclohexane
InChIKeyKORSJDCBLAPZEQ-UHFFFAOYSA-N
INCHI1S/C15H22N2O2/c18-10-16-14-5-1-12(2-6-14)9-13-3-7-15(8-4-13)17-11-19/h12-15H,1-9H2
Isomeric SMILES C1CC(CCC1CC2CCC(CC2)N=C=O)N=C=O
RTECS NQ9250000
UN Number 2206
Packing Group II
Molecular Weight 262.35
Reaxy-Rn 2217800
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2217800&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

KingdomOrganic compounds
SuperclassOrganic nitrogen compounds
ClassOrganonitrogen compounds
SubclassIsocyanates
Intermediate Tree Nodes Not available
Direct ParentIsocyanates
Alternative Parents Propargyl-type 1,3-dipolar organic compounds  Organopnictogen compounds  Organooxygen compounds  Organic oxides  Hydrocarbon derivatives  
Molecular FrameworkAliphatic homomonocyclic compounds
Substituents Isocyanate - Organic 1,3-dipolar compound - Propargyl-type 1,3-dipolar organic compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Aliphatic homomonocyclic compound
DescriptionThis compound belongs to the class of organic compounds known as isocyanates. These are organic compounds containing the isocyanic acid tautomer, HN=C=O, of cyanic acid, HOC#N or its hydrocarbyl derivatives RN=C=O.
External Descriptors diisocyanate
3D Structure
Interactive Chemical Structure Model





Associated Targets(Human)
AR Tclin Androgen Receptor (11781 Activities)
Activity TypeRelationActivity valueUnitsAction TypeJournalPubMed IddoiAssay Aladdin ID
Mechanisms of Action
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:

Find and download the COA for your product by matching the lot number on the packaging.

26 results found

Lot NumberCertificate TypeDateItem
K2119074Certificate of AnalysisSep 19, 2025 D155475
G2515154Certificate of AnalysisJun 26, 2025 D155475
G2515153Certificate of AnalysisJun 26, 2025 D155475
A2612052Certificate of AnalysisJun 26, 2025 D155475
G2515119Certificate of AnalysisJun 26, 2025 D155475
B2624266Certificate of AnalysisJun 26, 2025 D155475
D2623718Certificate of AnalysisJun 26, 2025 D155475
J2517179Certificate of AnalysisJun 26, 2025 D155475
L2011089Certificate of AnalysisSep 09, 2024 D155475
G2425765Certificate of AnalysisApr 12, 2024 D155475
G2425764Certificate of AnalysisApr 12, 2024 D155475
I2413340Certificate of AnalysisApr 12, 2024 D155475
I2413339Certificate of AnalysisApr 12, 2024 D155475
F2617012Certificate of AnalysisJan 10, 2024 D155475
D2630022Certificate of AnalysisJan 10, 2024 D155475
C2609076Certificate of AnalysisJan 10, 2024 D155475
B2510024Certificate of AnalysisJan 10, 2024 D155475
A2422271Certificate of AnalysisJan 10, 2024 D155475
A2422270Certificate of AnalysisJan 10, 2024 D155475
A2314100Certificate of AnalysisDec 28, 2022 D155475
L2411279Certificate of AnalysisDec 28, 2022 D155475
F2420056Certificate of AnalysisDec 28, 2022 D155475
A2314126Certificate of AnalysisDec 28, 2022 D155475
A2314117Certificate of AnalysisDec 28, 2022 D155475
A2314116Certificate of AnalysisDec 28, 2022 D155475
J2227156Certificate of AnalysisOct 31, 2022 D155475

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Chemical and Physical Properties
SolubilitySoluble in water; Soluble in Acetone
SensitivityMoisture sensitive;Heat sensitive
Refractive Index1.5
Boil Point(°C)168 °C/1.5 mmHg
Molecular Weight262.350 g/mol
XLogP35.300
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass262.168 Da
Monoisotopic Mass262.168 Da
Topological Polar Surface Area58.900 Ų
Heavy Atom Count19
Formal Charge0
Complexity332.000
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
The total count of all stereochemical bonds0
Covalently-Bonded Unit Count1
Documents & Articles
Adding a Temperature-Triggered Switch to NCO: How Blocked Isocyanates Affect the Storage, Curing, and Film Performance of 1K Baking Coatings
How Do Isocyanates and Polyols Affect the Performance of Polyurethane Coating Films: Structure, Raw Material Selection, and Performance Design Essentials
1K, 2K, Waterborne, Moisture-Curing, and Blocked Systems: Classification Logic and Identification Methods for Polyurethane Coating Curing Systems
Comprehensive Performance Analysis of Polyurethane Coating Films: Soft/Hard Segment Structure, Microphase Separation, Crosslinking and Curing, and Selection of Representative Chemicals
Film Formation and Curing Mechanisms of Polyester Resins for Coatings: From Functional Groups and Curing Systems to Crosslinked Networks
Polyurethane Coating Resins: Not a Single Resin, but a Designable High-Performance System
Applications and Selection of Acrylic Resins in Coatings: Analysis of Architectural, Industrial, and Supporting Materials
Guide to Common Waterborne Resin Types and Application-Based Selection: How to Choose Acrylics, PUD, Waterborne Epoxy, Waterborne Alkyd, VAE, and Related Chemicals
Mechanisms and Control of Coating Yellowing: From Chromophoric Structure Formation to Source Diagnosis and Formulation Optimization
Structural Design Logic of Common Resin Modification Technologies: Molecular Chain Structure, Functional Groups, Phase Structure, Crosslinked Networks, and Hybrid/Functional Design
Resin Polarity in Coating Formulations: From Molecular Structure to Dissolution, Compatibility, Interfacial Interactions, and Formulation Design
Citations of This Product
References
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51. Hao Wu, Zhou Lu, Ming Jin, Junhao Xie, Jinqiu Tao, Chengjun Yue, LEI DONG, Qianping Ran.  (2025)  Nature-inspired Dynamic Nanoconfinement Empowers Life-like Mechanical Adaptability and Robust Environmental Resilience in Polyurethane-urea Elastomers.  Journal of Materials Chemistry A,      [PMID:] [10.1039/D5TA04445F]
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