Moligand™, 10mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 1 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Didanosine Didanosine is a reverse transcriptase inhibitor with an IC50 of 0.49 μM.
In vitro
Didanosine induces cytoplasmic lipid droplet accumulations, increases lactate production and decreases activities of COX (complex IV) and SDH (part of complex II) in cultured human muscle cells. Didanosine is converted to its active moiety, dideoxyadenosine-5\'-triphosphate (ddATP), which inhibits HIV reverse transcriptase and terminates viral DNA growth in the target cell for HIV. Didanosine induces dose-dependent decreases in neurite number, length of the longest neurite in each neuron, and total neurite length per neuron in dissociated DRG cell cultures with 3 days treatment. Didanosine induces a neurite retraction or neurite loss in a dose-dependent manner in dissociated DRG neurons, suggesting that Didanosine may partially contribute to developing peripheral neuropathy. Didanosine potentiates the mutagenicity of Zidovudine in the thymidine kinase (TK) gene of cultured human TK6 lymphoblastoid cells. Didanosine combined with Zidovudine causes a significant increase in micronucleated PCEs and induces a significant increase in Tk mutants, which is associated with loss of the wild-type Tk+ allele. Didanosine depletes mitochondrial DNA (mtDNA) in cultured hepatocytes, this mtDNA depletion is associated with an increased in vitro production of lactate.
In vivo
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥95%
| ALogP | -1.2 |
|---|
| Isomeric SMILES | C1C[C@@H](O[C@@H]1CO)N2C=NC3=C2N=CNC3=O |
|---|---|
| RTECS | NM7460700 |
| Molecular Weight | 236.23 |
| Beilstein | 3619529 |
| Reaxy-Rn | 24723407 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24723407&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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View spec sheet →| Specific Rotation[α] | -28° (C=0.34,H2O) |
|---|---|
| Melt Point(°C) | 182°C |
| 1. Lei Xu, Jing Lu, Weiqi Meng, Fengjuan Cui. (2021) Determination of the Nucleoside Reverse Transcriptase Inhibitors Lamivudine, Stavudine, and Didanosine in Human Urine by Micellar Electrokinetic Chromatography Using the Ionic Liquid-Based Cationic Surfactant 1-Tetradecyl-3-Methylimidazolium Bromide. ANALYTICAL LETTERS, [PMID:] [10.1080/00032719.2021.1904970] |
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