Dihydroartemisinin (DHA) - Moligand™, 10mM in DMSO , CAS No.71939-50-9

CAS: 71939-50-9 Cat. No.: D408236 Molecular Weight: 284.35 EC Number: 615-698-8

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

Dihydroqinghaosu, β-Dihydroartemisinin, Artenimol | 3,12-Epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-ol, decahydro-3,6,9-trimethyl-, (3R,5aS,6R,8aS,9R,10S,12R,12aR)-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Dihydroartemisinin (DHA) Dihydroartemisinin (DHA, Dihydroqinghaosu, β-Dihydroartemisinin, Artenimol) is a semi-synthetic derivative of artemisinin and isolated from the traditional Chinese herb Artemisia annua. Dihydroartemisinin induces autophagy and a
In vitro

Dihydroartemisinin (DHA) inhibits the growth of certain cancer cell lines and xenograft tumors such as leukemia, glioma, fibrosarcoma, and breast, cervical, ovarian, lung, oral and pancreatic cancer. DHA inhibits cell and tumor growth by modulating various tumor-suppressive pathways, such as inhibiting cell proliferation and inducing apoptosis through regulation of proliferation- and apoptosis-related proteins.DHA inhibits the proliferation and viability of cells in a dose-dependent manner and induces apoptosis.DHA-mediated cytotoxicity is tumor selective. The endoperoxide bridge of DHA is reportedly essential for its cytotoxicity because it reacts with intracellular ferrous iron to generate reactive oxygen species or carbon-centered radicals, leading to cytotoxicity.

In vivo

DHA significantly inhibited HCC cell growth in vitro and in vivo via inducing G2/M cell cycle arrest and apoptosis. DHA has been shown in the rat whole embryo culture (WEC) to primarily affect primitive red blood cells (RBCs) causing subsequent tissue damage and dysmorphogenesis.
Cell Data

cell lines：Colo357FG/GLT, and Colo357L3.6pl/GLT

Concentrations：2.5, 10, 40, or 80 μM

Incubation Time：24, 48, and 72 h

Powder Purity:

Specifications

Synonyms

Dihydroqinghaosu, β-Dihydroartemisinin, Artenimol | 3, 12-Epoxy-12H-pyrano[4, 3-j]-1, 2-benzodioxepin-10-ol, decahydro-3, 6, 9-trimethyl-, (3R, 5aS, 6R, 8aS, 9R, 10S, 12R, 12aR)-

Specifications & Purity

Moligand™, 10mM in DMSO

Biochemical and Physiological Mechanisms

Dihydroartemisinin (DHA, Dihydroqinghaosu, β-Dihydroartemisinin, Artenimol) is a semi-synthetic derivative of artemisinin and isolated from the traditional Chinese herb Artemisia annua. Dihydroartemisinin induces autophagy and apoptosis by suppressing NF-

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Names and Identifiers

• Isomeric SMILES: C[C@@H]1CC[C@H]2[C@H]([C@H](O[C@H]3[C@@]24[C@H]1CC[C@](O3)(OO4)C)O)C
• RTECS: KD4165550
• Alternate CAS: 81496-82-4
• Molecular Weight: 284.35
• Reaxy-Rn: 25123268
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25123268&ln=

Chemical and Physical Properties

• Melt Point(°C): 145-150℃

References

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