(-)-Eburnamonine - Moligand™, ≥99% , Allosteric modulator of M 1 receptor;Allosteric modulator of M 2 receptor;Allosteric modulator of M 3 receptor;Allosteric modulator of M 4 receptor, CAS No.4880-88-0, Allosteric modulator of M 1 receptor;Allosteric modulator of M 2 receptor;Allosteric modulator of M 3 receptor;Allosteric modulator of M 4 receptor

CAS: 4880-88-0 Cat. No.: E348350 Molecular Weight: 294.39 Beilstein Registry Number: 4706903 EC Number: 225-490-5

COA

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(-)-Eburnamonine - Moligand™, ≥99% CAS No(4880-88-0) by Aladdin Scientific

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AVAILABLE TO ORDER

GRADE & PURITY Moligand™ ? ≥99%

Synonyms

HY-B1180 | NCIStruc2_000870 | 2-((6-(Benzylamino)-9-methyl-9H-purin-2-yl)amino)ethanol | 2-Methyldiphenhydramine | C09149 | Eburnamin-14(15H)-one, (3-alpha,16-alpha)- | (-)-Vincamone | GTPL345 | IDI1_000411 | CH-846 | DB13793 | HMS2096J16 | AC-26459 | BS-

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview Specifications Product Properties Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solution Calculators Reviews

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Why this grade

Moligand™, ≥99% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

(-)-Eburnamonine is a vasodilator that also acts as a cerebral metabolic stimulant. The compound can protect the cerebral of mice exposed to potassium cyanide intoxication. Studies show that (-)-Eburnamonine increases the affinity of acetylcholine on the M2 and M4 receptors, as well as augment the affinity of carbachol , bethanechol, furmethide, methylfurmethide, pentylthio-TZTP, pilocarpine, oxotremorine and oxotremorine-M on the M2 receptors. Research also shows that (-)-Eburnamonine has antihypoxic effects.

Specifications

Synonyms

HY-B1180 | NCIStruc2_000870 | 2-((6-(Benzylamino)-9-methyl-9H-purin-2-yl)amino)ethanol | 2-Methyldiphenhydramine | C09149 | Eburnamin-14(15H)-one, (3-alpha, 16-alpha)- | (-)-Vincamone | GTPL345 | IDI1_000411 | CH-846 | DB13793 | HMS2096J16 | AC-26459 | BS-

Specifications & Purity

Moligand™, ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

ALLOSTERIC MODULATOR

Mechanism of action

Allosteric modulator of M 1 receptor;Allosteric modulator of M 2 receptor;Allosteric modulator of M 3 receptor;Allosteric modulator of M 4 receptor

Purity

≥99%

Product Properties

pKa	pKa: 8.13

Names and Identifiers

Pubchem Sid	504754610
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504754610
Canonical Smiles	CCC12CCCN3C1C4=C(CC3)C5=CC=CC=C5N4C(=O)C2
IUPAC Name	(15S,19S)-15-ethyl-1,11-diazapentacyclo[9.6.2.02,7.08,18.015,19]nonadeca-2,4,6,8(18)-tetraen-17-one
InChIKey	WYJAPUKIYAZSEM-MOPGFXCFSA-N
INCHI	1S/C19H22N2O/c1-2-19-9-5-10-20-11-8-14-13-6-3-4-7-15(13)21(16(22)12-19)17(14)18(19)20/h3-4,6-7,18H,2,5,8-12H2,1H3/t18-,19+/m1/s1
Isomeric SMILES	CC[C@@]12CCCN3[C@@H]1C4=C(CC3)C5=CC=CC=C5N4C(=O)C2
WGK Germany	2
RTECS	YY8575570
Molecular Weight	294.39
Beilstein	4706903
Reaxy-Rn	759171
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=759171&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

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📊 Datasheet

Quick-reference summary of product specifications and applications.

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🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Alkaloids and derivatives
  - Class Eburnan-type alkaloids

Kingdom	Organic compounds
Superclass	Alkaloids and derivatives
Class	Eburnan-type alkaloids
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Eburnan-type alkaloids
Alternative Parents	Indolonaphthyridine alkaloids Beta carbolines 3-alkylindoles Naphthyridines Aralkylamines Piperidines Benzenoids Pyrroles Heteroaromatic compounds Trialkylamines Lactams Azacyclic compounds Organic oxides Organooxygen compounds Organopnictogen compounds Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Eburna alkaloid - Indolo[3,2-1de][1,5]naphthyridine - Beta-carboline - Pyridoindole - Diazanaphthalene - Naphthyridine - 3-alkylindole - Indole - Indole or derivatives - Aralkylamine - Piperidine - Benzenoid - Heteroaromatic compound - Pyrrole - Tertiary amine - Lactam - Tertiary aliphatic amine - Azacycle - Organoheterocyclic compound - Amine - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as eburnan-type alkaloids. These are alkaloids with a structure based on the eburnan skeleton, that arises from rearrangement of the aspidospermidine ring system, involving migration of C-21 from C-7 to C-2, fission of the 2,16-bond, and attachment of C-16 to N-1.
External Descriptors	Indole alkaloids
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D Structure

Associated Targets(Human)

CHRM3 Tclin Muscarinic acetylcholine receptor M3 (1 Activities)

Discover Target: CHRM3

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRM4 Tclin Muscarinic acetylcholine receptor M4 (1 Activities)

Discover Target: CHRM4

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRM2 Tclin Muscarinic acetylcholine receptor M2 (1 Activities)

Discover Target: CHRM2

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

CHRM1 Tclin Muscarinic acetylcholine receptor M1 (1 Activities)

Discover Target: CHRM1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

ACHE Tclin Acetylcholinesterase (18204 Activities)

Discover Target: ACHE

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

GLP1R Tclin Glucagon-like peptide 1 receptor (111429 Activities)

Discover Target: GLP1R

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A498 (42825 Activities)

Lot Number	Certificate Type	Date	Item
K2209561	Certificate of Analysis	Aug 12, 2025	E348350
K2209562	Certificate of Analysis	Aug 12, 2025	E348350
K2209570	Certificate of Analysis	Aug 12, 2025	E348350

Solubility	Soluble in chloroform.
Refractive Index	n20D1.72 (Predicted)
Specific Rotation[α]	α20/D -94.5°±2°, c = 1 in chloroform
Boil Point(°C)	441.88° C at 760 mmHg (Predicted)
Melt Point(°C)	174-176°C
Molecular Weight	294.400 g/mol
XLogP3	3.000
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	1
Exact Mass	294.173 Da
Monoisotopic Mass	294.173 Da
Topological Polar Surface Area	25.200 Å²
Heavy Atom Count	22
Formal Charge	0
Complexity	492.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	2
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Why this grade

Storage & shipping

Quality documents

Literature proof

Overview

Specifications

Documentation

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

Customer Reviews

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