Ethionamide - 10mM in DMSO , CAS No.536-33-4

CAS: 536-33-4 Cat. No.: E408837 Summenformel: C₈H₁₀N₂S Molekulargewicht: 166.24 Beilstein Registry Number: 22(5)2,360 EG-Nummer: 208-628-9

GRADE & PURITY 10mM in DMSO

Synonyms

Bayer 5312 | 2-​ethyl-4-​pyridinecarbothioami​de

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Übersicht

Information

Ethionamide (Bayer 5312) is anantibioticused in the treatment of tuberculosis.
In vitro

Ethionamide is a structural analogue of isoniazid (INH), both are pro-drugs that need to be activated by mycobacterial enzymes to exert their antimicrobial activity. Ethionamide mechanism of action is thought to be identical to INH although the pathway of activation is distinct from that of INH. Ethionamide is activated by an EthA enzyme, leading to the formation of a Soxide metabolite that has considerably better activity than the parent drug. Ethionamide inhibits both biofilm formation and viability of mature biofilms. Ethionamide reduces the content of ergosterol in Cryptococcus spp. planktonic cells and destabilized or permeabilized the fungal cell membrane, leading to leakage of macromolecules. Ethionamide is in general toxic at concentrations above 0.50 mM to HepG2, Caco-2, and RAW macrophage cells, but the toxicity is drastically reduced when Ethionamide is loaded into the microparticles. Ethionamide shows a fast metabolization process in the presence of the thermally carbonized- Porous silicon (TCPSi) particles. Ethionamide is activated in Mycobacterium tuberculosis by the protein encoded by the gene Rv3854c. Ethionamide appear to disrupt cell wall biosynthesis and have at least one common cellular target, the enoyl-acyl carrier protein reductase InhA.

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyme

Bayer 5312 | 2-​ethyl-4-​pyridinecarbothioami​de

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

Ethionamide (Bayer 5312) is an antibiotic used in the treatment of tuberculosis.

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Produkteigenschaften

• ALogP: 1.1

Namen und Kennungen

• Isomere SMILES: CCC1=NC=CC(=C1)C(=S)N
• WGK Deutschland: 3
• RTECS: NS0350000
• Molekulargewicht: 166.24
• Beilstein: 22(5)2,360
• Reaxy-Rn: 116474
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=116474&ln=

Chemische und physikalische Eigenschaften

• Siedepunkt (°C): 167°C/1mmHg
• Schmelzpunkt (°C): 162°C

Referenzen

1. Ying Zhang, Xie-an Yu, Yiting Hu, Xuefei Bai, Ran Zhang, Mi Lu, Jianhui Sun, Jiangwei Tian, Bo-Yang Yu.  (2020)  A polydopamine-polyethyleneimine/quantum dot sensor for instantaneous readout of cell surface charge to reflect cell states.  SENSORS AND ACTUATORS B-CHEMICAL,      [PMID:] [10.1016/j.snb.2020.128696]

Häufig gestellte Fragen

How should this product be stored?

Store at ?80 °C. Ultra-low temperature storage is required to maintain the specified shelf life.

How is this product shipped?

This product ships frozen with dry ice and cold packs. Unpack on arrival and transfer it to the storage condition stated above; handle dry ice with insulated gloves in a ventilated area.

What are the CAS number, molecular formula and molecular weight?

The CAS Number is 536-33-4, the molecular formula is C8H10N2S, and the molecular weight is 166.24 g/mol.

What documentation is provided?

Available product documentation, including Certificates of Analysis (COA), Safety Data Sheets (SDS), and specification sheets, is shown in the product document area. Document availability and access follow the current site policy.