What are the limitations of Foucault alkylation reaction?
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What are the limitations of Foucault alkylation reaction?
·Reviewed·Published ·Updated ·8 min read
What are the limitations of Foucault alkylation reaction?
① Due to the extremely unstable carbocation formed by aryl and vinyl halides, it cannot be used for this reaction.
② The presence of passivation groups on the aromatic ring, such as NH2 groups, can lead to the deactivation of the catalyst due to the formation of complex compounds.
③ Excessive aromatic compounds must be used in these reactions to avoid polyalkylation (adding more than one alkyl group to the aromatic compound).
④ Aromatic compounds with lower activity than monohalobenzenes do not participate in the Friedel-Crafts alkylation reaction.
Da — when not otherwise indicated, molecular weight units are daltons. Mw — weight-average molecular weight. Mn — number-average molecular weight.
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Aladdin Scientific. "What are the limitations of Foucault alkylation reaction?" Aladdin Knowledge Base, updated Oct 9, 2023. https://www.aladdinsci.com/us_en/faqs/what-are-the-limitations-of-foucault-alkylation-reaction-en.html
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