Fenofibrate (NSC-281319) - Moligand™, 10mM in DMSO , Peroxisome proliferator-activated receptor alpha agonist, CAS No.49562-28-9, Peroxisome proliferator-activated receptor alpha agonist

CAS: 49562-28-9 Cat. No.: F409229 Molecular Weight: 360.83 EC Number: 256-376-3
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GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
Synonyms
2-​[4-​(4-​chlorobenzoyl)​phenoxy]​-​2-​methyl-propanoic acid-1-​methylethyl ester
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
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Size
Status
Price
Qty
1ml
F409229-1ml
1

$119.90

$139.90
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Why this grade

Moligand™, 10mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 20 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Information

Fenofibrate (NSC-281319) is a compound of the fibrate class and fibric acid derivative. Fenofibrate is a selective agonist ofPPARαwith EC50 of 30 μM. Fenofibrate binds to and inhibitscytochrome P450 epoxygenase (CYP)2Cwith IC50 of 0.2 μM, 0.7 μM and 9.7 μ
In vitro


In vivo


Cell Data

cell lines:

Concentrations:

Incubation Time:

Powder Purity:≥99%

Specifications

Synonyms
2-​[4-​(4-​chlorobenzoyl)​phenoxy]​-​2-​methyl-propanoic acid-1-​methylethyl ester
Specifications & Purity
Moligand™, 10mM in DMSO
Biochemical and Physiological Mechanisms
Fenofibrate (NSC-281319) is a compound of the fibrate class and fibric acid derivative. Fenofibrate is a selective agonist of PPARα with EC50 of 30 μM. Fenofibrate binds to and inhibits cytochrome P450 epoxygenase (CYP)2C with IC50 of 0.2 μM, 0.7 μM and 9
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Moligand™
Action Type
AGONIST, INHIBITOR
Mechanism of action
Peroxisome proliferator-activated receptor alpha agonist
Product Properties
ALogP5.2
Names and Identifiers
Isomeric SMILES CC(C)OC(=O)C(C)(C)OC1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)Cl
WGK Germany 3
RTECS UA2453400
Molecular Weight 360.83
Reaxy-Rn 2062462
Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2062462&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Associated Targets(Human)
FABP1 Tchem Fatty acid-binding protein, liver (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
PPARA Tclin Peroxisome proliferator-activated receptor alpha (1 Activities)
Activity TypeActivity Value -log(M)Mechanism of ActionActivity ReferencePublications (PubMed IDs)
Certificates(CoA,COO,BSE/TSE and Analysis Chart)
C of A & Other Certificates(BSE/TSE, COO):
Analytical Chart:
Chemical and Physical Properties
Melt Point(°C)81°C
Citations of This Product
References
1. Qianyu Wu, Yu Zhang, Ce Sun, Jun Dang.  (2025)  Online bioactivity-guided HPLC-lipoprotein lipase system with medium-high pressure chromatography for rapid recognition and targeted isolation of natural affinity agents from Nitraria tangutorum.  JOURNAL OF CHROMATOGRAPHY A,      [PMID:40972433] [10.1016/j.chroma.2025.466384]
2. Zhang Li, Tong Yingying, Fang Yan, Pei Jinjin, Wang Qilan, Li Gang.  (2023)  Exploring the hypolipidemic effects of bergenin from Saxifraga melanocentra Franch: mechanistic insights and potential for hyperlipidemia treatment.  Lipids in Health and Disease,  22  (1): (1-16).  [PMID:38001454] [10.1186/s12944-023-01973-2]
3. Xueyun Liu, Man Hu, Chen Ye, Lihong Liao, Chang Ding, Lijuan Sun, Jichao Liang, Yong Chen.  (2022)  Isosilybin regulates lipogenesis and fatty acid oxidation via the AMPK/SREBP-1c/PPARα pathway.  CHEMICO-BIOLOGICAL INTERACTIONS,      [PMID:36347319] [10.1016/j.cbi.2022.110250]
4. Sa Yang, Shijie Cao, Congyu Li, Jichao Zhang, Chang Liu, Feng Qiu, Ning Kang.  (2022)  Berberrubine, a Main Metabolite of Berberine, Alleviates Non-Alcoholic Fatty Liver Disease via Modulating Glucose and Lipid Metabolism and Restoring Gut Microbiota.  Frontiers in Pharmacology,      [PMID:35873595] [10.3389/fphar.2022.913378]
5. Miaomiao Chi, Kunming Qin, Lei Cao, Min Zhang, Yingying Su, Xun Gao.  (2022)  Surface Functionalized Magnetic Nanoparticles as a Selective Sorbent for Affinity Fishing of PPAR-γ Ligands from Choerospondias axillaris.  MOLECULES,  27  (10): (3127).  [PMID:35630609] [10.3390/molecules27103127]
6. Qin Yeyu, Xie Jing, Zheng Ruihe, Li Yuhang, Wang Haixia.  (2022)  Oleoylethanolamide as a New Therapeutic Strategy to Alleviate Doxorubicin-Induced Cardiotoxicity.  Frontiers in Pharmacology,      [PMID:35517792] [10.3389/fphar.2022.863322]
7. Yan-Yu Zhang, Jun-Xian Wang, Jiong Ren, Jie Wang, Fang Qiao, Mei-Ling Zhang, Zhen-Yu Du.  (2021)  Activation of peroxisome proliferator-activated receptor-α stimulated lipid catabolism in liver of largemouth bass, Micropterus salmoides.  AQUACULTURE NUTRITION,  27  (6): (2749-2758).  [PMID:] [10.1111/anu.13400]
8. Emmanuel Omari-Siaw, Qilong Wang, Congyong Sun, Zengquan Gu, Yuan Zhu, Xia Cao, Caleb Kesse Firempong, Rita Agyare, Ximing Xu, Jiangnan Yu.  (2016)  Tissue distribution and enhanced in vivo anti-hyperlipidemic-antioxidant effects of perillaldehyde-loaded liposomal nanoformulation against Poloxamer 407-induced hyperlipidemia.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,      [PMID:27567929] [10.1016/j.ijpharm.2016.08.042]
9. Shuyu Li, Di Wu, Hui Yu, Xin Huang, Na Wang, Ting Wang, Hongxun Hao.  (2025)  A novel energy-efficient way to prepare solid lipid microspheres loaded with nanoscale drugs by combining LLPS and in-situ crystallization.  Particuology,      [PMID:] [10.1016/j.partic.2025.03.015]
10. Shengzheng Guo, Yuechao Cao, Yuxin Zhang, Yan Wang, Zhenguo Gao, Junbo Gong.  (2024)  A Scalable Freeze-Dissolving Approach to Prepare Ultrafine Crystals for Inhalation: Mechanism and Validation.  CRYSTAL GROWTH & DESIGN,      [PMID:] [10.1021/acs.cgd.4c00018]
11. Haotian Zhang, Xiaoying Chen, Hua Rong, Baojia Chen, Junfeng Guang, Qing Pan, Xiaobo Wen, Lijun Ning.  (2025)  Indispensable role of PGC1α signaling in lipid and carbohydrate metabolism of fish PPARα activation.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:40049462] [10.1016/j.ijbiomac.2025.141722]
12. Shuyu Li, Di Wu, Hui Yu, Xin Huang, Na Wang, Ting Wang, Hongxun Hao.  (2025)  Low-Temperature Liquid–Liquid Phase Separation Strategy for In Situ Preparation of Porous Solid Lipid Microspheres Loaded with Fenofibrate Nanocrystals.  CRYSTAL GROWTH & DESIGN,      [PMID:] [10.1021/acs.cgd.4c01580]
13. Yang Yu Mei, Ma Hang Bin, Xiong Yue, Wu Qian, Gao Xiu Kui.  (2025)  PEX11B palmitoylation couples peroxisomal dysfunction with Schwann cells fail in diabetic neuropathy.  JOURNAL OF BIOMEDICAL SCIENCE,  32  (1): (1-17).  [PMID:39934809] [10.1186/s12929-024-01115-5]
14. Wanhao Qi, Jinghao Chen, Shiqiao Rui, Shi Li, Yiduo Ding, Shuaipeng Feng, Zhu Liu, Qiwei Liu, Siling Wang, Qinfu Zhao.  (2025)  Variable pore size of mesoporous silica in improving physical stability and oral bioavailability of insoluble drugs.  INTERNATIONAL JOURNAL OF PHARMACEUTICS,      [PMID:40010525] [10.1016/j.ijpharm.2025.125394]
15. Lu Tianshu, Wu Yiyang, Xiong Ping, Zhong Hao, Ding Yang, Li Haifeng, Ouyang Defang.  (2025)  Combining High-Throughput Screening and Machine Learning to Predict the Formation of Both Binary and Ternary Amorphous Solid Dispersion Formulations for Early Drug Discovery and Development.  PHARMACEUTICAL RESEARCH,      [PMID:40180767] [10.1007/s11095-025-03853-z]
16. Mingtian Tian, Jiahong Dong, Yuhong Guo, Yihe Zhao, Jianxin Cao.  (2025)  Beneficial effects of soluble dietary fiber from Dendrocalamus brandisii Munro shoots on high-fat diet-induced metabolic disorders in mice: impact on liver, adipose tissue, and intestinal health.  Food Hydrocolloids for Health,      [PMID:] [10.1016/j.fhfh.2025.100217]
17. Jiayu Song, Huanhuan Zhang, Xiaohui Zhang, Meiying Liu, Dan Peng, Yuan Ren, Yan Sun, Yunlan Li.  (2025)  Galactose-modified erythrocyte membrane fusion liposomes enable the targeted delivery of drug nanoparticles to the liver.  RSC Advances,  15  (22): (17781-17794).  [PMID:40443690] [10.1039/D4RA07489K]
18. Ming Chu, Yingying Tong, Lei Zhang, Yu Zhang, Jun Dang, Gang Li.  (2025)  Flavone C-Glycosides from Dianthus superbus L. Attenuate Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) via Multi-Pathway Regulations.  Nutrients,  17  (15): (2456).  [PMID:40806041] [10.3390/nu17152456]
19. Man Wang, Yi Chen, Ming Guo, Pengzhi Xie, Xinzhe Zhao, Shulin Chen, Yian Deng, Rui Hu, Qianyi Wan, Juanyu Zhou, Zhuzhen Zhang, Ke Lan, Haiyang Chen, Yuan Liu.  (2026)  Impaired VLCFA-peroxisome-mediated intestinal epithelial repair causes gastrointestinal sequelae of long COVID.  DEVELOPMENTAL CELL,      [PMID:41494535] [10.1016/j.devcel.2025.12.003]
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