10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Argon charged,Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 77 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Ferrostatin-1 (Fer-1) Ferrostatin-1 (Fer-1) is a potent and selective inhibitor of ferroptosis with EC50 of 60 nM.
In vitro
Ferrostatin-1 (2 μM) prevents erastin-induced ferroptosis in cancer cells, as well as glutamate-induced cell death in postnatal rat brain slices. Ferrostatin-1 is a lipid ROS scavenger, with the N-cyclohexyl moiety serving as a lipo-philic anchor within biological membranes. Ferrostatin-1 does not inhibit extracellular signal -regulated kinase (ERK) phos-phorylation or arrest the proliferation of HT-1080 cells, suggesting that it does not inhibit the MEK/ERK pathway, chelate iron, or inhibit protein synthesis. Ferrostatin-1 does, however, prevent erastin-induced accumulation of cytosolic and lipid ROS. Ferrostatin-1 readily oxidizes the stable radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) under cell-free conditions.
In vivo
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥99%
| Isomeric SMILES | CCOC(=O)C1=CC(=C(C=C1)NC2CCCCC2)N |
|---|---|
| Molecular Weight | 262.35 |
| Reaxy-Rn | 9413226 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9413226&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Sensitivity | Sensitive to light; sensitive to heating; |
|---|---|
| Melt Point(°C) | 106 °C |
| 1. Xiaosi Lin, Le Dong, Qing Miao, Zhaobin Huang, Fang Wang. (2024) Cycloheptylprodigiosin from marine bacterium Spartinivicinus ruber MCCC 1K03745T induces a novel form of cell death characterized by Golgi disruption and enhanced secretion of cathepsin D in Non-small cell lung cancer cell lines. EUROPEAN JOURNAL OF PHARMACOLOGY, [PMID:38663542] [10.1016/j.ejphar.2024.176608] |
| 2. Haoze Song, Jing Liang, Yuanyuan Guo, Yang Liu, Kuiru Sa, Guohong Yan, Wen Xu, Wei Xu, Lixia Chen, Hua Li. (2023) A potent GPX4 degrader to induce ferroptosis in HT1080 cells. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, [PMID:38194774] [10.1016/j.ejmech.2023.116110] |
| 3. Xi Wang, Wenjing Zhu, Miao Xing, Haiyan Zhu, Enqing Chen, Jie Zhou. (2023) Matrine disrupts Nrf2/GPX4 antioxidant system and promotes hepatocyte ferroptosis. CHEMICO-BIOLOGICAL INTERACTIONS, [PMID:37716422] [10.1016/j.cbi.2023.110713] |
| 4. Yu-Chen Chen, Qiong Zheng, Hui Lu, Yi-Xin Zhuang, Ting-Ting Gong, Lie-Feng Ma, Zha-Jun Zhan. (2023) Neuroprotective flavonoids from Epimedium brevicornu by inhibition of ferroptosis. Phytochemistry Letters, [PMID:] [10.1016/j.phytol.2023.04.003] |
| 5. Wenhua Wang, Wenhao Wang, Shiwei Jin, Fangqin Fu, Zhengwei Huang, Ying Huang, Chuanbin Wu, Xin Pan. (2023) Open pocket and tighten holes: Inhalable lung cancer-targeted nanocomposite for enhanced ferroptosis-apoptosis synergetic therapy. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2023.141487] |
| 6. Huiyi Li, Qiqing Weng, Shuai Gong, Weixian Zhang, Jiaqi Wang, Yuqiao Huang, Yuanjun Li, Jiao Guo, Tian Lan. (2023) Kaempferol prevents acetaminophen-induced liver injury by suppressing hepatocyte ferroptosis via Nrf2 pathway activation. Food & Function, 14 (4): (1884-1896). [PMID:36723004] [10.1039/D2FO02716J] |
| 7. Mingbo Wu, Wenwu Ling, Jiaojun Wei, Ran Liao, Haiyue Sun, Dongqiu Li, Ye Zhao, Long Zhao. (2022) Biomimetic photosensitizer nanocrystals trigger enhanced ferroptosis for improving cancer treatment. JOURNAL OF CONTROLLED RELEASE, [PMID:36402233] [10.1016/j.jconrel.2022.11.026] |
| 8. Huan Huang, Yuling Chen, Na Yin, Gaojie Li, Shanshan Ye, Ling Guo, Min Feng. (2022) Unsaturated Fatty Acid Liposomes Selectively Regulate Glutathione Peroxidase 4 to Exacerbate Lipid Peroxidation as an Adaptable Liposome Platform for Anti-Tumor Therapy. MOLECULAR PHARMACEUTICS, [PMID:36368878] [10.1021/acs.molpharmaceut.2c00642] |
| 9. Li Xie, Wenjie Chen, Qifang Chen, Yang Jiang, Erqun Song, Xiaokang Zhu, Yang Song. (2022) Synergistic hydroxyl radical formation, system XC- inhibition and heat shock protein crosslinking tango in ferrotherapy: A prove-of-concept study of “sword and shield” theory. Materials Today Bio, [PMID:35865409] [10.1016/j.mtbio.2022.100353] |
| 10. Shuwei Qiao, Baosheng Li, Qing Cai, Zhen Li, Zhaoyi Yin, Jie He, Yuyang Li, Weiyan Meng. (2022) Involvement of ferroptosis in Porphyromonas gingivalis lipopolysaccharide-stimulated periodontitis in vitro and in vivo. ORAL DISEASES, [PMID:35765229] [10.1111/odi.14292] |
| 11. Hao Chi, Guang Zhu, Yalin Yin, He Diao, Zicheng Liu, Shibo Sun, Zhaoming Guo, Weiping Xu, Jianqiang Xu, Changhao Cui, Xiao-Jin Xing, Kun Ma. (2022) Dual-Responsive multifunctional “core–shell” magnetic nanoparticles promoting Fenton reaction for tumor ferroptosis therapy. INTERNATIONAL JOURNAL OF PHARMACEUTICS, [PMID:35688287] [10.1016/j.ijpharm.2022.121898] |
| 12. Haibao Peng, Xingcai Zhang, Peng Yang, Jiaxu Zhao, Wei Zhang, Nianping Feng, Wuli Yang, Jing Tang. (2021) Defect self-assembly of metal-organic framework triggers ferroptosis to overcome resistance. Bioactive Materials, [PMID:35415315] [10.1016/j.bioactmat.2021.12.018] |
| 13. Xiazhen Bao, Xuehui Cao, Yong Yuan, Bo Zhou, Congde Huo. (2021) A water-soluble, highly sensitive and ultrafast fluorescence probe for imaging of mitochondrial hypochlorous acid. SENSORS AND ACTUATORS B-CHEMICAL, [PMID:] [10.1016/j.snb.2021.130210] |
| 14. Guo Lin, Zhang Jia, Li Yuqiang, Gao Yuehong, Huang Jiali, Liu Mengru, Li Jing, Chai Wenshu, Li Yubin. (2025) 3,3′-diindolylmethane induces ferroptosis and inhibits proliferation in non-small-cell lung cancer through the AHR/NRF2/GPX4 axis. Discover Oncology, 16 (1): (1-18). [PMID:40100489] [10.1007/s12672-025-02096-z] |
| 15. Qingchen Bai, Miao Wang, Kai Wang, Jingwei Liu, Fengyu Qu, Huiming Lin. (2024) CuPc-Fe@BSA nanocomposite: Intracellular acid-sensitive aggregation for enhanced sonodynamic and chemo-therapy. JOURNAL OF COLLOID AND INTERFACE SCIENCE, [PMID:38820842] [10.1016/j.jcis.2024.05.113] |
| 16. Xinyu Zhang, Hui Liu, Chenyu Wang, Yuan Gao, Shiqi Zhao, Mengyao Mu, Ke Ren, Yufang Gong, Qing Fan, Xiao Sun. (2025) Dimeric PD-L1 specific affibody grafted Fe-based nanosheets for tumor-targeting dual-mode magnet resonance imaging and enhancement of Photothermal-Immunotherapy. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2025.159400] |
| 17. Xiaoyu Wang, Chunzhe Xu, Hantao Tian, Yu Pang, Jie Lv, Meng Li. (2025) FeS embedded bioreactor collaborate with artesunate for cascade-catalytic tumor ferroptosis. JOURNAL OF COLLOID AND INTERFACE SCIENCE, [PMID:40184656] [10.1016/j.jcis.2025.137479] |
| 18. Yu Fu, Guiqin Huang, Yawen Cai, Menghui Ren, Run Cheng, Yuhui Chai, Yingdi Wang, Yunqi An, Tianhua Yan, Lingpeng Zhu, Xinxin Liu. (2025) Integrated network pharmacology, bioinformatics, and experiment analysis to decipher the molecular mechanism of Salidroside on Gastric cancer via targeting NCOA4-mediated ferritinophagy. CHEMICO-BIOLOGICAL INTERACTIONS, [PMID:39746501] [10.1016/j.cbi.2024.111368] |
| 19. Xin Zheng, Xinyi Tang, Yinan Xu, Haiyan Zhu, Lianwei Zhong, Chen Chen, Jiajun Cui, Jie Zhou. (2025) Sodium aescinate induces hepatotoxicity through apoptosis and ferroptosis by inhibiting the Nrf2/CTH pathway. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:40064321] [10.1016/j.jep.2025.119608] |
| 20. Lin Shuai, Cai Hui, Song Xuemei. (2024) Synergy between isobavachalcone and doxorubicin suppressed the progression of anaplastic thyroid cancer through ferroptosis activation. BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH, [PMID:39166605] [10.1590/1414-431X2024e13679] |
| 21. Ningjun Shao, Kedan Cai, Yue Hong, Lingping Wu, Qun Luo. (2025) USP9X suppresses ferroptosis in diabetic kidney disease by deubiquitinating Nrf2 in vitro. RENAL FAILURE, [PMID:39967230] [10.1080/0886022X.2025.2458761] |
| 22. Tianfeng Yang, Suyu Zhang, Kun Nie, Xiuhong Peng, Jian Huo, Xiao Fu, Yanmin Zhang. (2025) WWOX-mediated p53/SAT1 and NRF2/FPN1 axis contribute to toosendanin-induced ferroptosis in hepatocellular carcinoma. BIOCHEMICAL PHARMACOLOGY, [PMID:39894307] [10.1016/j.bcp.2025.116790] |
| 23. Chen Yuxing, Tao Yong, Huang Qiu, Xu Jingtao, Wang Zhenxin, Zhang Ye, Fu Guangxu, Tan Fuqiang, Feng Keyi, Ou Yunsheng. (2025) Hino-Fe Chelate Suppresses Osteosarcoma Progression through Dual Induction of Ferroptosis and NLRC4-mediated Pyroptosis: Mechanisms and Therapeutic Implications. International Journal of Biological Sciences, 21 (11): (4872-4894). [PMID:40860199] [10.7150/ijbs.113785] |
| 24. Tianyu Zhao, Yuping Zhang, Qianqian Song, Qingxuan Meng, Xinrui Meng, Xiaolong Wang, Jing Cong. (2025) Environmental toxicity of tire wear and latex particle leachates in zebrafish embryos: Oxidative stress and ferroptosis as key mechanisms. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, [PMID:40633707] [10.1016/j.cbpc.2025.110285] |
| 25. Shichen Zhang, Lei Guo, Yixin Tang, Yixing Wang, Heshi Liu, Chang Liu, Xiuzhang Yan, Congcong Duan, Huanyan Dai, Bing Han, Caina Xu. (2025) Self-reinforced nanoreactor for apoptosis/ferroptosis synergistic therapy of head and neck squamous cell carcinoma. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2025.166941] |
| 26. Kai Sun, Jiajia Ruan, Jiale Dai, Xinran Yang, Jiaying Yu, Hongshuai Wu, Jiaxing Xu. (2025) A reversible fluorescent probe based on On-Off-On switching cycle to track the dynamic signaling of ferroptosis. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2025.167454] |
| 27. Yu-Lin Zhong, Bing-Bing Wang, Kai-Fei Chu, Ai-Jun Wang, Tiejun Zhao, Jiu-Ju Feng. (2025) High-entropy intermetallic alloy/carbon nanoflower cascade nanozyme for multi-modal synergistic cancer therapy. JOURNAL OF COLLOID AND INTERFACE SCIENCE, [PMID:40845442] [10.1016/j.jcis.2025.138753] |
| 28. Xue Shi, Yun Zhao, Hong-Yu Gao, Wei Yang, Jun Liao, Hui-Han Wang, Xiao-Tian Wang, Wei Yan. (2025) NFS1, together with FXN, protects cells from ferroptosis and DNA damage in diffuse large B-cell lymphoma. Redox Biology, [PMID:41005206] [10.1016/j.redox.2025.103878] |
| 29. Wēi Wang, Jian Zhang, Song-Lin Jiang, Zhi-Min Rao, Hui Liu, Lei Wang, Chun-Li Cai, Xin-Chang Xu, Chen-Huan Yu, Wéi Wang. (2025) Dictamnine inhibited keratinocyte hyperproliferation and alleviated psoriasis-like dermatitis via blocking HIF1A-mediated ferroptotic pathway. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:40945883] [10.1016/j.jep.2025.120607] |
| 30. Wei-Wei Zheng, Jia-Xuan Ding, Yang-Xin Liang, Ling Ye. (2025) Hydroxypropyl‑β‑cyclodextrin/thymoquinone inclusion complex inhibits non‑small cell lung cancer progression through NF‑κB‑mediated ferroptosis. ONCOLOGY REPORTS, 54 (6): (1-14). [PMID:40970359] [10.3892/or.2025.8990] |
| 31. Yijing Yang, Ying Wang, Ying Deng, Jing Lu, Li Xiao, Jie Li, Yasha Zhou, Fujiao Nie, Xiangdong Chen, Jun Peng, Hanyu Tan, Yuhui Qin, Qinghua Peng. (2023) Fructus Lycii and Salvia miltiorrhiza Bunge extract attenuate oxidative stress-induced photoreceptor ferroptosis in retinitis pigmentosa. BIOMEDICINE & PHARMACOTHERAPY, [PMID:37741257] [10.1016/j.biopha.2023.115547] |
| 32. Suleixin Yang, Yi Wu, Wenzhao Zhong, Ruie Chen, Meilin Wang, Meiwan Chen. (2023) GSH/Ph Dual Activatable Crosslinked And Fluorinated Pei for Cancer Gene Therapy Through Endogenous Iron De-Hijacking And in Situ Ros Amplification. ADVANCED MATERIALS, [PMID:37689975] [10.1002/adma.202304098] |
| 33. Tianxiang Wang, Changmei Yang, Zhiqiang Li, Ting Li, Ran Zhang, Yujiao Zhao, Tianyi Cheng, Zhaoyun Zong, Yingying Ma, Dongyuan Zhang, Haiteng Deng. (2023) Flavonoid 4,4′-dimethoxychalcone selectively eliminates senescent cells via activating ferritinophagy. Redox Biology, [PMID:38176315] [10.1016/j.redox.2023.103017] |
| 34. Wei Li, Chang Liu, Sichuan Wang, Naifeng Liu. (2023) Neutrophil membrane biomimetic delivery system (Ptdser-NM-Lipo/Fer-1) designed for targeting atherosclerosis therapy. IET Nanobiotechnology, 17 (4): (387-395). [PMID:37183611] [10.1049/nbt2.12137] |
| 35. Zhao Hongting, Zhang Meng, Zhang Jinghua, Sun Zichen, Zhang Wenxin, Dong Weichen, Cheng Chen, Yao Yongzhong, Li Kuanyu. (2023) Hinokitiol-iron complex is a ferroptosis inducer to inhibit triple-negative breast tumor growth. Cell and Bioscience, 13 (1): (1-15). [PMID:37179385] [10.1186/s13578-023-01044-0] |
| 36. Xia Chen, Rong Wu, Lei Li, Yunong Zeng, Jingrui Chen, Mingyuan Wei, Yinglin Feng, Guiming Chen, Yuhang Wang, Lizhen Lin, Haihua Luo, Ali Chen, Zhenhua Zeng, Fangjie He, Yang Bai, Siyou Zhang, Yubing Han, Zhang Wang, Xiaoshan Zhao, Wei Xiao, Yong Jiang, Shenhai Gong. (2023) Pregnancy-induced changes to the gut microbiota drive macrophage pyroptosis and exacerbate septic inflammation. IMMUNITY, [PMID:36792573] [10.1016/j.immuni.2023.01.015] |
| 37. Feng-guo Zhai, Qi-chao Liang, Yi-yan Wu, Jia-qi Liu, Jia-wei Liu. (2022) Red ginseng polysaccharide exhibits anticancer activity through GPX4 downregulation-induced ferroptosis. PHARMACEUTICAL BIOLOGY, [PMID:35575436] [10.1080/13880209.2022.2066139] |
| 38. Wenhao Wang, Fangqin Fu, Zhengwei Huang, Wenhua Wang, Minglong Chen, Xiao Yue, Jintao Fu, Xiaoqian Feng, Ying Huang, Chuanbin Wu, Xin Pan. (2022) Inhalable Biomimetic Protein Corona-Mediated Nanoreactor for Self-Amplified Lung Adenocarcinoma Ferroptosis Therapy. ACS Nano, [PMID:35575209] [10.1021/acsnano.2c02634] |
| 39. Fengfan Liu, Xiang Cheng, Shuang Wu, Bei Hu, Chen Yang, Shufen Deng, Qiwen Shi. (2022) Nickel oxide nanoparticles induce apoptosis and ferroptosis in airway epithelial cells via ATF3. ENVIRONMENTAL TOXICOLOGY, 37 (5): (1093-1103). [PMID:35061333] [10.1002/tox.23467] |
| 40. Zhiwei Wang, Mingxing Li, Yuanfeng Liu, Zhentao Qiao, Tao Bai, Ling Yang, Bo Liu. (2021) Dihydroartemisinin triggers ferroptosis in primary liver cancer cells by promoting and unfolded protein response‑induced upregulation of CHAC1 expression. ONCOLOGY REPORTS, 46 (5): (1-14). [PMID:34558645] [10.3892/or.2021.8191] |
| 41. Rong Fan, Jidong Sui, Xuepeng Dong, Biao Jing, Zhenming Gao. (2021) Wedelolactone alleviates acute pancreatitis and associated lung injury via GPX4 mediated suppression of pyroptosis and ferroptosis. FREE RADICAL BIOLOGY AND MEDICINE, [PMID:34246777] [10.1016/j.freeradbiomed.2021.07.009] |
| 42. Wenjun Liu, Jieyuan Zhang, Liang Ding, Weifeng Ni, Junjie Yuan, Haijun Xiao, Jingwei Zhang. (2021) RBC-derived nanosystem with enhanced ferroptosis triggered by oxygen-boosted phototherapy for synergized tumor treatment. Biomaterials Science, 9 (21): (7228-7236). [PMID:34585181] [10.1039/D1BM00175B] |
| 43. Tao Bai, Ruopeng Liang, Rongtao Zhu, Weijie Wang, Lin Zhou, Yuling Sun. (2020) MicroRNA-214-3p enhances erastin-induced ferroptosis by targeting ATF4 in hepatoma cells. JOURNAL OF CELLULAR PHYSIOLOGY, [PMID:31960438] [10.1002/jcp.29496] |
| 44. Shanshan Guo, Lang Zhou, Xueqi Liu, Li Gao, Yuanyuan Li, Yonggui Wu. (2024) Baicalein alleviates cisplatin-induced acute kidney injury by inhibiting ALOX12-dependent ferroptosis. PHYTOMEDICINE, [PMID:38805781] [10.1016/j.phymed.2024.155757] |
| 45. Zi-Han Xu, Ming-Min Xie, Chun-Lan Xie, Xian-Wen Yang, Jun-Song Wang. (2025) Deep-Sea-Derived Isobisvertinol Targets TLR4 to Exhibit Neuroprotective Activity via Anti-Inflammatory and Ferroptosis-Inhibitory Effects. Marine Drugs, 23 (1): (49). [PMID:39852551] [10.3390/md23010049] |
| 46. Lei Shu, Peili Luo, Qingxin Chen, Jingyang Liu, Ying Huang, Chuanbin Wu, Xin Pan, Zhengwei Huang. (2024) Fibroin nanodisruptor with Ferroptosis-Autophagy synergism is potent for lung cancer treatment. INTERNATIONAL JOURNAL OF PHARMACEUTICS, [PMID:39142466] [10.1016/j.ijpharm.2024.124582] |
| 47. Qin Chen, Fen-Sheng Qiu, Wei Xie, Wen-Ying Yu, Zhao-An Su, Guang-Ming Qin, You-Kun Kang, Song-Lin Jiang, Chen-Huan Yu. (2024) Gypenoside A-loaded mPEG-PLGA nanoparticles ameliorate high-glucose-induced retinal microvasculopathy by inhibiting ferroptosis. INTERNATIONAL JOURNAL OF PHARMACEUTICS, [PMID:39326476] [10.1016/j.ijpharm.2024.124758] |
| 48. Jiani Zhan, Yijia Chen, Yuying Liu, Yunqiu Chen, Zhiyao Li, Xuewen Li, Zhenning He, Fangzhou Meng, Xiaoyang Qian, Lili Yang, Qing Yang. (2025) IDO1-mediated AhR activation up-regulates pentose phosphate pathway via NRF2 to inhibit ferroptosis in lung cancer. BIOCHEMICAL PHARMACOLOGY, [PMID:40164341] [10.1016/j.bcp.2025.116913] |
| 49. Chen Kechun, Xu Bingtian, Long Lu, Wen Huizhen, Zhao Qian, Tu Xingxing, Wang Jiakang, Xu Jiangping, Wang Haitao. (2024) Inhibition of Phosphodiesterase 4 Suppresses Neuronal Ferroptosis After Cerebral Ischemia/Reperfusion. MOLECULAR NEUROBIOLOGY, [PMID:39287745] [10.1007/s12035-024-04495-9] |
| 50. Xue Panpan, Zhuang Huilan, Bai Tingjie, Zeng Xuemei, Deng Jinpeng, Shao Sijie, Yan Shuangqian. (2024) Iron (II)-based metal-organic framework nanozyme for boosting tumor ferroptosis through inhibiting DNA damage repair and system Xc-. JOURNAL OF NANOBIOTECHNOLOGY, 22 (1): (1-16). [PMID:38715049] [10.1186/s12951-024-02508-2] |
| 51. Wenying Wei, Haifei Kang, Chenxi Lian, Jiawei Liu, Jinwei Lin, Junwei Yang, Zhangmancang Xu, Ziqi Wang, Meizhen Yin, Honglian Dai. (2024) Iron-based magnetic nanocomplexes for combined chemodynamic and photothermal cancer therapy through enhanced ferroptosis. Biomaterials Advances, [PMID:39332345] [10.1016/j.bioadv.2024.214046] |
| 52. Haiyan Zhu, Yijing Yang, Yenan Duan, Xin Zheng, Zixiong Lin, Jie Zhou. (2024) Nrf2/FSP1/CoQ10 axis-mediated ferroptosis is involved in sodium aescinate-induced nephrotoxicity. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, [PMID:39033970] [10.1016/j.abb.2024.110100] |
| 53. Shuheng Qin, Hui-yue Zhao, Xing-yu Luo, Fei Wang, Jun Liu, Yin Ding, Yong Hu. (2024) Photothermally Reinforced Nanozyme Remodeling Tumor Microenvironment of Redox and Metabolic Homeostasis to Enhance Ferroptosis in Tumor Therapy. ACS Nano, [PMID:39499796] [10.1021/acsnano.4c13087] |
| 54. Lipeng Zhu, Dongliang Leng, Ziang Guo, Yuetao Zhao, Kam-Tong Leung, Yeneng Dai, Junnan Li, Qi Zhao. (2024) Self-catalyzed nitric oxide nanocomplexes induce ferroptosis for cancer immunotherapy. JOURNAL OF CONTROLLED RELEASE, [PMID:39580079] [10.1016/j.jconrel.2024.11.048] |
| 55. Fang Liu, Yaru Li, Yao Li, Zheng Wang, Xin Li, Yancheng Liu, Yanjun Zhao. (2024) Triggering multiple modalities of cell death via dual-responsive nanomedicines to address the narrow therapeutic window of β-lapachone. JOURNAL OF COLLOID AND INTERFACE SCIENCE, [PMID:39270391] [10.1016/j.jcis.2024.09.063] |
| 56. Zhou Yi, Luan Fengwu, Feng Xiaonan, Yu Min, Li Lu, Guo Xiaoyan, Yin Xiaolong. (2025) TGF-β1 induces ROS to activate ferroptosis via the ERK1/2-WISP1 pathway to promote the progression of renal tubular epithelial cell fibrosis. CYTOTECHNOLOGY, 77 (2): (1-18). [PMID:39959788] [10.1007/s10616-025-00719-5] |
| 57. Bin Liu, Cun-Long Wang, Teng-Zhou Li, Jian-Xue Feng, Yu-Qing Ma, Ling Liu, Ping Li, Zhi-Hua Li. (2025) Developmental toxicity and mechanistic insights of tralopyril in marine medaka: Epigenetic disruptions and ferroptosis. Environmental Chemistry and Ecotoxicology, [PMID:] [10.1016/j.enceco.2025.05.014] |
| 58. Jie Zhou, Yurou Li, Chen Xi, Wupei Pan, Qin Yu, Zhengping Wu. (2025) Apigenin Alleviates Fumonisin B1-Induced Hepatotoxicity by Suppressing Ferroptosis through the Nrf2/FSP1 Pathway. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, [PMID:41073359] [10.1021/acs.jafc.5c08870] |
| 59. Yong-xiang Huang, Jin-ru Zhang, Shi-hua Fu, Zhe Liu, Hui-jun Zhong, Qing-yang Zhong, Yin-di Luo, Ying-jie Hu, Hai-peng Zhu, Bin Wen, Song Chen. (2025) Indirubin regulates M1/M2 polarization and inhibits ferroptosis in dextran sulfate sodium induced colitis and in cultured THP-1 cells. PHARMACEUTICAL BIOLOGY, [PMID:41074553] [10.1080/13880209.2025.2568215] |
| 60. Lin Li, Yanyan Wu, Weiwei Wang, Kejing Wang, Lin Chen. (2025) Delivery of a GPX4 Inhibitor by SN38 Prodrug Nanoassemblies for Amplified Antitumor Efficacy Based on Ferroptotic Chemotherapy. ChemMedChem, [PMID:41056556] [10.1002/cmdc.202500667] |
| 61. Jiajian Wang, Lanqing Zhang, Runfang Li, Rui Yang, Fan Yang, Fei Yu, Jihong Zhang. (2025) Gambogic acid restores wild-type-like p53 functions to induce ferroptosis in mutant p53 cancer cells. BIOCHEMICAL PHARMACOLOGY, [PMID:41213406] [10.1016/j.bcp.2025.117533] |
| 62. Yuzhu Wu, Xinwang Chen, Feixiang Liu, Yanchen Feng, Ziyun Liao, Xinyu Bu, Wen Fu, Jing Gao, Lihua Wu, Linyuan Fan, Qian Yang, Penglin Yue, Mengyu Wang. (2025) Mechanistic study on electroacupuncture-regulated circadian autophagy for inhibiting ferroptosis in hippocampal neurons and alleviating depression-like behaviors in adulthood induced by early chronic sleep deprivation. Frontiers in Neurology, [PMID:41255782] [10.3389/fneur.2025.1680606] |
| 63. Su Cui, Li Yu, Hao Liu, Wenhan Liu, Daiwang Shi. (2025) Tumor redox heterogeneity-responsive nanoparticles for enhanced antitumor efficacy through combining chemo/chemodynamic therapy. International Journal of Pharmaceutics-X, [PMID:41399401] [10.1016/j.ijpx.2025.100455] |
| 64. Lin Li, Tiantian Lei, Kejing Wang, Yong Liu, Bingjun Sun, Lin Chen. (2025) GPX4 Inhibitor-Driven Doxorubicin Homodimeric Prodrug Nanoassemblies with Synergistic Chemotherapy-Ferroptosis for Triple-Negative Breast Cancer Therapy. ACS Applied Nano Materials, [PMID:] [10.1021/acsanm.5c03980] |
| 65. Zhenyu Yang, Ziming Wang, Jingsheng Huang, Meiqi Luo, Xinling Luo, Weiqi Zeng, Yingxin Gao, Fei Huang, Zhizhao Deng, Dongdong Yuan. (2025) EMP1-driven Ferroptosis in Liver Sinusoidal Endothelial Cells Exacerbates Hepatic Ischemia-Reperfusion Injury via P38 MAPK. FREE RADICAL BIOLOGY AND MEDICINE, [PMID:41352380] [10.1016/j.freeradbiomed.2025.12.002] |
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