Flumazenil (RO 15-1788) - Moligand™, 10mM in DMSO , Allosteric modulator of GABA A receptor α1 subunit;Allosteric modulator of GABA A receptor α2 subunit;Allosteric modulator of GABA A receptor α3 subunit;Allosteric modulator of GABA A receptor α4 subunit, Allosteric modulator of GABA A receptor α1 subunit;Allosteric modulator of GABA A receptor α2 subunit;Allosteric modulator of GABA A receptor α3 subunit;Allosteric modulator of GABA A receptor α4 subunit;Allosteric modulator of GABA A receptor α5 subunit;
Flumazenil (RO 15-1788) - Moligand™, 10mM in DMSO , Allosteric modulator of GABA A receptor α1 subunit;Allosteric modulator of GABA A receptor α2 subunit;Allosteric modulator of GABA A receptor α3 subunit;Allosteric modulator of GABA A receptor α4 subunit, Allosteric modulator of GABA A receptor α1 subunit;Allosteric modulator of GABA A receptor α2 subunit;Allosteric modulator of GABA A receptor α3 subunit;Allosteric modulator of GABA A receptor α4 subunit;Allosteric modulator of GABA A receptor α5 subunit;
GRADE & PURITYMoligand™?Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.10mM in DMSO
Moligand™, 10mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 4 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
Information
Flumazenil (RO 15-1788) is a competitiveGABAA receptorantagonist, used in the treatment of benzodiazepine overdoses. In vitro
In vivo
Flumazenil interacts at the central benzodiazepine receptor to antagonize or reverse the behavioral, neurologic, and electrophysiologic effects of benzodiazepine agonists and inverse agonists. Flumazenil is of some benefit in hepatic encephalopathy, but until well-designed clinical trials are conducted, hepatic encephalopathy must be considered an investigational indication for flumazenil. Flumazenil has been shown to reverse sedation caused by intoxication with benzodiazepines alone or benzodiazepines in combination with other agents, but it should not be used when cyclic antidepressant intoxication is suspected. Flumazenil (1 mg/kg) induces a strong anxiolytic effect in BALB/c mice tested in the elevated plus maze and light/dark test. Flumazenil (10 mg/kg) effectively prevents the reduction produced by allopregnanolone in rats. Flumazenil (5-20 mg/kg) antagonizes the anticonvulsant and adverse effects of diazepam but not GYKI 52466 in mice. Flumazenil slightly reduces the anticonvulsant activity of NBQX in the MES model but not in the PTZ test. Flumazenil (3.0 mg/kg) blocks the changes withdrawal from chronic ethanol treatment, which leads to a decrease in open arm time and percent open arm entries. Cell Data
Flumazenil (RO 15-1788) is a competitive GABAA receptor antagonist, used in the treatment of benzodiazepine overdoses.
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
Grade
Moligand™
Action Type
ALLOSTERIC MODULATOR
Mechanism of action
Allosteric modulator of GABA A receptor α1 subunit;Allosteric modulator of GABA A receptor α2 subunit;Allosteric modulator of GABA A receptor α3 subunit;Allosteric modulator of GABA A receptor α4 subunit;Allosteric modulator of GABA A receptor α5 subunit;
1.Niping Li, Yaorong Yang, Shengyuan Zhang, Bin Jiang, Wei Zhang, Haibo Wang, Lixin Chen, Liwei Wang, Yiyi Li, Lei Shi, Wencai Ye, Lei Wang. (2025) The toxic components, toxicological mechanism and effective antidote for Gelsemium elegans poisoning. Acta Pharmaceutica Sinica B, [PMID:41049747][10.1016/j.apsb.2025.07.016]
2.Jing Jiang, Zhao-liang Hu, Hamza Boucetta, Jia-ming Liu, Min Song, Tai-jun Hang, Yu-ting Lu. (2022) Identification of degradation products in flumazenil using LC-Q-TOF/MS and NMR: Degradation pathway elucidation. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, [PMID:35447492][10.1016/j.jpba.2022.114764]
3.Nan Zhang, Mu Luo, Lei He, Lei Yao. (2020) Chemical Composition of Essential Oil from Flower of ‘Shanzhizi’ (Gardenia jasminoides Ellis) and Involvement of Serotonergic System in Its Anxiolytic Effect. MOLECULES, 25 (20):(4702). [PMID:33066512][10.3390/molecules25204702]
4.Kai Zhang, Jing Lu, Lei Yao. (2019) Involvement of the dopamine D1 receptor system in the anxiolytic effect of cedrol in the elevated plus maze and light–dark box tests. JOURNAL OF PHARMACOLOGICAL SCIENCES, [PMID:31786058][10.1016/j.jphs.2019.11.004]
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