Fluoromethyl 1,1,1,3,3,3-Hexafluoroisopropyl Ether - Moligand™, 10mM in DMSO , Potassium channel subfamily K member 2 opener, CAS No.28523-86-6, Potassium channel subfamily K member 2 opener

CAS: 28523-86-6 Cat. No.: F422995 Molecular Weight: 200.05 EC Number: 643-089-7

GRADE & PURITY Moligand™, 10mM in DMSO

Synonyms

sevoflurane|28523-86-6|1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane|Sevofluran|Ultane|Sevorane|Sojourn|MR6S4|sevoflo|Sevoflurano|Sevofluranum|Sevofluranum [INN-Latin]|Sevoflurano [INN-Spanish]|Sevocalm|Petrem|Fluoromethyl 1,1,1,3,3,3-Hexafluoroisopropy

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Specifications

Synonyms

sevoflurane | 28523-86-6 | 1, 1, 1, 3, 3, 3-Hexafluoro-2-(fluoromethoxy)propane | Sevofluran | Ultane | Sevorane | Sojourn | MR6S4 | sevoflo | Sevoflurano | Sevofluranum | Sevofluranum [INN-Latin] | Sevoflurano [INN-Spanish] | Sevocalm | Petrem | Fluoromethyl 1, 1, 1, 3, 3, 3-Hexafluoroisopropy

Specifications & Purity

Moligand™, 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

POSITIVE MODULATOR

Mechanism of action

Potassium channel subfamily K member 2 opener

Product Properties

• ALogP: 2.8

Names and Identifiers

• Canonical Smiles: C(OC(C(F)(F)F)C(F)(F)F)F
• IUPAC Name: 1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)propane
• InChIKey: DFEYYRMXOJXZRJ-UHFFFAOYSA-N
• INCHI: 1S/C4H3F7O/c5-1-12-2(3(6,7)8)4(9,10)11/h2H,1H2
• Isomeric SMILES: C(OC(C(F)(F)F)C(F)(F)F)F
• WGK Germany: 1
• RTECS: KO0737000
• Molecular Weight: 200.05
• Reaxy-Rn: 2041023
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=2041023&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic oxygen compounds
    • Class Organooxygen compounds
      • Subclass Ethers

• Kingdom: Organic compounds
• Superclass: Organic oxygen compounds
• Class: Organooxygen compounds
• Subclass: Ethers
• Intermediate Tree Nodes: Not available
• Direct Parent: Dialkyl ethers
• Alternative Parents: Organofluorides Hydrocarbon derivatives Alkyl fluorides
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Dialkyl ether - Hydrocarbon derivative - Organofluoride - Organohalogen compound - Alkyl halide - Alkyl fluoride - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as dialkyl ethers. These are organic compounds containing the dialkyl ether functional group, with the formula ROR', where R and R' are alkyl groups.
• External Descriptors: organofluorine compound - ether

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(non-human)

Plasmodium falciparum (966862 Activities)

Explore this target

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Sensitivity: Heat sensitive
• Boil Point(°C): 58°C
• Molecular Weight: 200.050 g/mol
• XLogP3: 2.800
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 2
• Exact Mass: 200.007 Da
• Monoisotopic Mass: 200.007 Da
• Topological Polar Surface Area: 9.200 Ų
• Heavy Atom Count: 12
• Formal Charge: 0
• Complexity: 121.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Shan Jiang, Chonghe Wang, Jingyao Zhu, Xuezhu Huang.  (2021)  Regulation of glial cell-derived neurotrophic factor in sevoflurane-induced neuronal apoptosis by long non-coding RNA CDKN2B-AS1 as a ceRNA to adsorb miR-133.  American Journal of Translational Research,      [PMID:34150056] [PMID:34150056]