Furosemide sodium - 10mM in DMSO , CAS No.41733-55-5

CAS: 41733-55-5 Cat. No.: F423888 Molecular Weight: 352.73 EC Number: 255-526-5 PubChem CID: 23673593

GRADE & PURITY 10mM in DMSO

Synonyms

D07999 | Sodium furosemide | sodium;4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoate | Frosemide sodium | Q27251094 | HY-B0135A | FUROSEMIDE SODIUM [WHO-DD] | SODIUM 4-CHLORO-2-(2-FURYLMETHYLAMINO)-5-SULFAMOYL-BENZOATE | Benzoic acid, 5-(aminosulfon

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Furosemide (Frusemide) sodium is a potent and orally active inhibitor ofNa-K-Cl cotransporter (NKCC). Furosemide sodium is a subtype-selective antagonist ofgamma-aminobutyric acid type A (GABAA) receptor.

Targets

NKCC ; GABAA receptor

Specifications

Synonyms

D07999 | Sodium furosemide | sodium;4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoate | Frosemide sodium | Q27251094 | HY-B0135A | FUROSEMIDE SODIUM [WHO-DD] | SODIUM 4-CHLORO-2-(2-FURYLMETHYLAMINO)-5-SULFAMOYL-BENZOATE | Benzoic acid, 5-(aminosulfon

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Furosemide (Frusemide) sodium is a potent and orally active inhibitor of Na-K-Cl cotransporter (NKCC). Furosemide sodium is a subtype-selective antagonist of gamma-aminobutyric acid type A (GABAA) receptor.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Product Properties

• ALogP: -0.071
• HBD Count: 2
• Rotatable Bond: 5

Names and Identifiers

• Canonical Smiles: C1=COC(=C1)CNC2=CC(=C(C=C2C(=O)[O-])S(=O)(=O)N)Cl.[Na+]
• IUPAC Name: sodium;4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoate
• InChIKey: DLFCAVBMDSKMEY-UHFFFAOYSA-M
• INCHI: 1S/C12H11ClN2O5S.Na/c13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19;/h1-5,15H,6H2,(H,16,17)(H2,14,18,19);/q;+1/p-1
• Isomeric SMILES: C1=COC(=C1)CNC2=CC(=C(C=C2C(=O)[O-])S(=O)(=O)N)Cl.[Na+]
• PubChem CID: 23673593
• Molecular Weight: 352.73

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Benzenoids
    • Class Benzene and substituted derivatives
      • Subclass Benzenesulfonamides

• Kingdom: Organic compounds
• Superclass: Benzenoids
• Class: Benzene and substituted derivatives
• Subclass: Benzenesulfonamides
• Intermediate Tree Nodes: Not available
• Direct Parent: Aminobenzenesulfonamides
• Alternative Parents: 4-halobenzoic acids Aminobenzoic acids Halobenzoic acids Benzenesulfonyl compounds Benzoic acids Aniline and substituted anilines Benzoyl derivatives Phenylalkylamines Secondary alkylarylamines Chlorobenzenes Organosulfonamides Aryl chlorides Heteroaromatic compounds Furans Vinylogous amides Aminosulfonyl compounds Carboxylic acid salts Amino acids Carboxylic acids Oxacyclic compounds Organic metal halides Organic oxides Organic sodium salts Organic zwitterions Organochlorides Organooxygen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Aminobenzenesulfonamide - Aminobenzoic acid - Aminobenzoic acid or derivatives - Halobenzoic acid - 4-halobenzoic acid - Halobenzoic acid or derivatives - 4-halobenzoic acid or derivatives - Benzenesulfonyl group - Benzoic acid or derivatives - Benzoic acid - Benzoyl - Phenylalkylamine - Aniline or substituted anilines - Chlorobenzene - Halobenzene - Secondary aliphatic/aromatic amine - Aralkylamine - Organosulfonic acid amide - Aryl chloride - Aryl halide - Heteroaromatic compound - Furan - Organic sulfonic acid or derivatives - Organosulfonic acid or derivatives - Vinylogous amide - Sulfonyl - Aminosulfonyl compound - Amino acid - Carboxylic acid salt - Amino acid or derivatives - Secondary amine - Organoheterocyclic compound - Organic metal halide - Oxacycle - Carboxylic acid derivative - Carboxylic acid - Organic alkali metal salt - Organic oxide - Organic sodium salt - Organohalogen compound - Organochloride - Organonitrogen compound - Amine - Hydrocarbon derivative - Organooxygen compound - Organic nitrogen compound - Organic oxygen compound - Organosulfur compound - Organic salt - Organic zwitterion - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as aminobenzenesulfonamides. These are organic compounds containing a benzenesulfonamide moiety with an amine group attached to the benzene ring.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• DMSO(mg / mL) Max Solubility: 71
• DMSO(mM) Max Solubility: 201.287103450231
• Water(mg / mL) Max Solubility: 71
• Water(mM) Max Solubility: 201.287103450231
• Molecular Weight: 352.730 g/mol
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 5
• Exact Mass: 351.99 Da
• Monoisotopic Mass: 351.99 Da
• Topological Polar Surface Area: 134.000 Ų
• Heavy Atom Count: 22
• Formal Charge: 0
• Complexity: 486.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3