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· · COA & SDS available for every product · Same-day shipping on in-stock items GDC-0349 - ≥99% , Serine/threonine-protein kinase mTOR inhibitor, CAS No.1207360-89-1, Serine/threonine-protein kinase mTOR inhibitor
Synonyms
579255I6O9 | EX-A2248 | Q27261488 | UNII-579255I6O9 | MLS006011173 | NSC780878 | NSC-780878 | (S)-1-ethyl-3-(4-(4-(3-methylmorpholino)-7-(oxetan-3-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-2-yl)phenyl)urea | HY-15248 | NSC771532 | NSC-771532 | BDBM5042
Shipped In
Ice chest + Ice pads
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Why this grade ≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview Product description
GDC-0349 is a potent and selective ATP-competitive mTOR inhibitor with a Ki of 3.8 nM. GDC-0349 inhibits of both mTORC1 and mTORC2 complexes.
Specifications Synonyms
579255I6O9 | EX-A2248 | Q27261488 | UNII-579255I6O9 | MLS006011173 | NSC780878 | NSC-780878 | (S)-1-ethyl-3-(4-(4-(3-methylmorpholino)-7-(oxetan-3-yl)-5, 6, 7, 8-tetrahydropyrido[3, 4-d]pyrimidin-2-yl)phenyl)urea | HY-15248 | NSC771532 | NSC-771532 | BDBM5042
Specifications & Purity
≥99%
Biochemical and Physiological Mechanisms
GDC-0349 is a potent mTOR inhibitor. GDC-0349 has entered in a phase I clinical trials in the treatment of Solid Tumors or Non Hodgkin's Lymphoma.
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Mechanism of action
Serine/threonine-protein kinase mTOR inhibitor
Names and Identifiers Pubchem Sid 504771729 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504771729 Canonical Smiles CCNC(=O)NC1=CC=C(C=C1)C2=NC3=C(CCN(C3)C4COC4)C(=N2)N5CCOCC5C IUPAC Name 1-ethyl-3-[4-[4-[(3S)-3-methylmorpholin-4-yl]-7-(oxetan-3-yl)-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-2-yl]phenyl]urea InChIKey RGJOJUGRHPQXGF-INIZCTEOSA-N INCHI 1S/C24H32N6O3/c1-3-25-24(31)26-18-6-4-17(5-7-18)22-27-21-12-29(19-14-33-15-19)9-8-20(21)23(28-22)30-10-11-32-13-16(30)2/h4-7,16,19H,3,8-15H2,1-2H3,(H2,25,26,31)/t16-/m0/s1 Isomeric SMILES CCNC(=O)NC1=CC=C(C=C1)C2=NC3=C(CCN(C3)C4COC4)C(=N2)N5CCOC[C@@H]5C Molecular Weight 452.55 Reaxy-Rn 52178663 Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=52178663&ln=
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organoheterocyclic compounds Class Pyridopyrimidines Subclass Not available Intermediate Tree Nodes Not available Direct Parent Pyridopyrimidines Alternative Parents N-phenylureas Dialkylarylamines Aminopyrimidines and derivatives Aralkylamines Morpholines Imidolactams Heteroaromatic compounds Ureas Trialkylamines Oxetanes Oxacyclic compounds Azacyclic compounds Dialkyl ethers Carbonyl compounds Organic oxides Hydrocarbon derivatives Molecular Framework Aromatic heteropolycyclic compounds Substituents N-phenylurea - Pyridopyrimidine - Dialkylarylamine - Aminopyrimidine - Aralkylamine - Monocyclic benzene moiety - Morpholine - Oxazinane - Pyrimidine - Benzenoid - Imidolactam - Heteroaromatic compound - Urea - Tertiary aliphatic amine - Tertiary amine - Oxetane - Oxacycle - Azacycle - Dialkyl ether - Ether - Amine - Organic oxygen compound - Organic nitrogen compound - Organonitrogen compound - Carbonyl group - Organooxygen compound - Hydrocarbon derivative - Organic oxide - Aromatic heteropolycyclic compound Description This compound belongs to the class of organic compounds known as pyridopyrimidines. These are compounds containing a pyridopyrimidine, which consists of a pyridine fused to a pyrimidine. Pyridine is 6-membered ring consisting of five carbon atoms and a nitrogen atom. Pyrimidine is a 6-membered ring consisting of four carbon atoms and two nitrogen centers at the 1- and 3- ring positions. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solubility DMSO 91 mg/mL Water <1 mg/mL Ethanol 6 mg/mL Molecular Weight 452.500 g/mol XLogP3 1.400 Hydrogen Bond Donor Count 2 Hydrogen Bond Acceptor Count 7 Rotatable Bond Count 5 Exact Mass 452.254 Da Monoisotopic Mass 452.254 Da Topological Polar Surface Area 91.900 Ų Heavy Atom Count 33 Formal Charge 0 Complexity 656.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 1 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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