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· · COA & SDS available for every product · Same-day shipping on in-stock items GNE-617 - ≥98% , CAS No.1362154-70-8
Synonyms
Imidazo[1,2-a]pyridine-6-carboxamide,N-[[4-[(3,5-difluorophenyl)sulfonyl]phenyl]methyl]-
Shipped In
Ice chest + Ice pads
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Why this grade ≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview Information
GNE-617 GNE-617 is a highly potent inhibitor of NAMPT activity with an IC50 of 5 nM.
Targets
NAMPT (Cell-free assay) 5 nM
Specifications Synonyms
Imidazo[1, 2-a]pyridine-6-carboxamide, N-[[4-[(3, 5-difluorophenyl)sulfonyl]phenyl]methyl]-
Specifications & Purity
≥98%
Biochemical and Physiological Mechanisms
GNE-617 is a highly potent inhibitor of NAMPT activity with an IC50 of 5 nM.
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Product Properties ALogP 2.875 hba_count 4 HBD Count 1 Rotatable Bond 5
Names and Identifiers Pubchem Sid 504771936 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504771936 Canonical Smiles C1=CC(=CC=C1CNC(=O)C2=CN3C=CN=C3C=C2)S(=O)(=O)C4=CC(=CC(=C4)F)F IUPAC Name N-[[4-(3,5-difluorophenyl)sulfonylphenyl]methyl]imidazo[1,2-a]pyridine-6-carboxamide InChIKey XRDVXQQZLHVEQZ-UHFFFAOYSA-N INCHI 1S/C21H15F2N3O3S/c22-16-9-17(23)11-19(10-16)30(28,29)18-4-1-14(2-5-18)12-25-21(27)15-3-6-20-24-7-8-26(20)13-15/h1-11,13H,12H2,(H,25,27) Isomeric SMILES C1=CC(=CC=C1CNC(=O)C2=CN3C=CN=C3C=C2)S(=O)(=O)C4=CC(=CC(=C4)F)F Molecular Weight 427.42 Reaxy-Rn 22322434 Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=22322434&ln=
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organoheterocyclic compounds Class Imidazopyridines Subclass Not available Intermediate Tree Nodes Not available Direct Parent Imidazopyridines Alternative Parents Benzenesulfonyl compounds Pyridinecarboxamides Imidazo[1,2-a]pyridines Fluorobenzenes Aryl fluorides N-substituted imidazoles Vinylogous amides Sulfones Heteroaromatic compounds Secondary carboxylic acid amides Azacyclic compounds Organooxygen compounds Hydrocarbon derivatives Organonitrogen compounds Organic oxides Organofluorides Molecular Framework Aromatic heteropolycyclic compounds Substituents Imidazo[1,2-a]pyridine - Benzenesulfonyl group - Imidazopyridine - Pyridinecarboxamide - Pyridine carboxylic acid or derivatives - Fluorobenzene - Halobenzene - Aryl fluoride - Aryl halide - Monocyclic benzene moiety - N-substituted imidazole - Benzenoid - Pyridine - Azole - Heteroaromatic compound - Imidazole - Vinylogous amide - Sulfonyl - Sulfone - Carboxamide group - Secondary carboxylic acid amide - Azacycle - Carboxylic acid derivative - Organofluoride - Organohalogen compound - Organic oxygen compound - Organic nitrogen compound - Hydrocarbon derivative - Organonitrogen compound - Organooxygen compound - Organosulfur compound - Organic oxide - Aromatic heteropolycyclic compound Description This compound belongs to the class of organic compounds known as imidazopyridines. These are organic polycyclic compounds containing an imidazole ring fused to a pyridine ring. Imidazole is 5-membered ring consisting of three carbon atoms, and two nitrogen centers at the 1- and 3-positions. Pyridine is a 6-membered ring consisting of five carbon atoms and one nitrogen center. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solubility Solubility (25°C) In vitro DMSO: 42 mg/mL (98.26 mM); Water: Insoluble; Ethanol: Insoluble; DMSO(mg / mL) Max Solubility 42 DMSO(mM) Max Solubility 98.2640026203734 Water(mg / mL) Max Solubility ＜1 Molecular Weight 427.400 g/mol XLogP3 3.500 Hydrogen Bond Donor Count 1 Hydrogen Bond Acceptor Count 6 Rotatable Bond Count 5 Exact Mass 427.08 Da Monoisotopic Mass 427.08 Da Topological Polar Surface Area 88.900 Ų Heavy Atom Count 30 Formal Charge 0 Complexity 699.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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