≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
GSK-269984A is a Prostaglandin E2 Receptor 1 (EP1) antagonist with a pIC 50 of 7.9.
In Vitro
Results from [ 3 H]-PGE 2 binding assay in CHO cells overexpressing the human EP 1 receptor demonstrate that GSK-269984A is an antagonist of EP 1 receptor with a pIC 50 of 7.9. GSK-269984A is found to cause a concentration-dependent rightward shift of the PGE 2 dose-response curve and Schild analysis shows that GSK-269984A is a competitive antagonist with pA 2 8.1±0.3 and slope 1.0. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
GSK-269984A demonstrates an ED 50 of 2.6 mg/kg (po), with the 10 mg/kg dose showing equivalent reversal of hypersensitivity to the standard. GSK-269984A displays moderate blood clearance in the rat\nand dog and high clearance in the monkey which is reflected in the half-life for each species . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Form:Solid
IC50& Target:EP1 7.9 (pIC 50 )
Specifications
Synonyms
Q27280309 | GSK269984A | GSK-269984A | 2-Pyridinecarboxylic acid, 6-((5-chloro-2-((4-chloro-2-fluorophenyl)methoxy)phenyl)methyl)-, sodium salt (1:1) | Sodium 6-((5-chloro-2-(((4-chloro-2-fluorophenyl)methyl)oxy)phenyl)methyl)-2-pyridinecarboxylate | UNII
Specifications & Purity
≥99%
Biochemical and Physiological Mechanisms
GSK-269984A is a Prostaglandin E2 Receptor 1 (EP1) antagonist with a pIC 50 of 7.9.
Storage
Store at -20°C
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
This compound belongs to the class of organic compounds known as pyridinecarboxylic acids. These are compounds containing a pyridine ring bearing a carboxylic acid group.
External Descriptors
Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
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