10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 1 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
GSK'872 (GSK2399872A) GSK'872 (GSK2399872A) is a potent and selective RIP3 kinase inhibitor which binds RIP3 kinase domain with high affinity (IC50=1.8 nM) and inhibits kinase activity with IC50 of 1.3 nM. It has minimal cross-reactivity.
In vitro
When assayed at 1 μM, GSK\'872 fails to inhibit most of 300 human protein kinases tested. It fails to inhibit RIP1 kinase when tested directly. GSK\'872 blocks TNF-induced necroptosis in a concentration-dependent manner in HT-29 cells. In cell-based assays, there is a 100- to 1000-fold shift in the IC50 compared to the cell-free biochemical assays. GSK\'872 also blocks necroptosis in primary human neutrophils isolated from whole blood. GSK\'872 inhibits TLR3- or DAI-induced death, two RIP1-independent pathways of necroptosis. It induces caspase activation followed by apoptotic cell death.
In vivo
GSK\'872 treatment significantly decreases HIF-1α expression compared with no treatment after ischemia injury in vivo.
Cell Data
cell lines：
Concentrations：0.3, 1, 3 μM
Incubation Time：18 h
Powder Purity:≥99%
| Isomeric SMILES | CC(C)S(=O)(=O)C1=CC2=C(C=CN=C2C=C1)NC3=CC4=C(C=C3)SC=N4 |
|---|---|
| Molecular Weight | 383.48 |
| Reaxy-Rn | 25153150 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=25153150&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| 1. Chenying Zeng, Linjian Chen, Jiajie Lin, Zipeng Xiao, Qingqiang Tu, Wenhui Yu, Weihao Zhang, Qibo Li, Yanfeng Wu, Zhongyu Xie, Ziji Zhang. (2025) Taraxasterol Alleviates Osteoporosis by Targeting PI3K/AKT/PPARγ Signaling Axis to Suppress Necroptosis and Reverse Osteogenic-Adipogenic Differentiation Imbalance in BMSCs. PHYTOMEDICINE, [PMID:41317432] [10.1016/j.phymed.2025.157277] |
