GW-870086 - 10mM in DMSO , CAS No.827319-43-7

CAS: 827319-43-7 Cat. No.: G655123 Molecular Weight: 559.64 PubChem CID: 11376392

GRADE & PURITY 10mM in DMSO

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

GW-870086 is a potent anti-inflammatory agent, acting as a glucocorticoid receptor agonist, with a pIC 50 of 10.1 in A549 cells expressing NF-κB .

In Vitro

GW-870086 a glucocorticoid receptor agonist, inhibits NFkB reporter gene with a pIC 50 of 10.1, but shows no effect on the MMTV reporter genes in A549 cells, and has little or no activity at the oestrogen receptor, progesterone receptor, progesterone receptor, mineralocorticoid receptor or androgen receptor. GW-870086 (1 pM-1 μM) dose-dependently inhibits the L-6 release induced by TNF-α in A549 epithelial carcinoma cells and by IL-1 in MG63 osteosarcoma cells (pIC 50 s, 9.6, 10.2). GW-870086 (GW870086X; 10-100 nM) significantly increases fibronectin secretion. However, GW-870086 has no effect on MMP2 secretion, and does not increase cellular myocilin. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

IC50& Target:pIC50: 10.1 (glucocorticoid receptor, A549 NF-κB cells)

Specifications

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

GW-870086 is a potent anti-inflammatory agent, acting as a glucocorticoid receptor agonist, with a pIC 50 of 10.1 in A549 cells expressing NF-κB .

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

AGONIST

Names and Identifiers

• Isomeric SMILES: C[C@@H]1C[C@H]2[C@@H]3C[C@@H](C4=CC(=O)C=C[C@@]4([C@]3([C@H](C[C@@]2([C@]1(C(=O)OCC#N)OC(=O)C5C(C5(C)C)(C)C)C)O)F)C)F
• Alternate CAS: 827319-43-7
• PubChem CID: 11376392
• MeSH Entry Terms: GW870086;GW870086X
• Molecular Weight: 559.64