Moligand™, 10 mM in DMSO Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 17 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
(-)-Huperzine A (Huperzine A) is an alkaloid isolated from Huperzia serrata , with neuroprotective activity. (-)-Huperzine A is a potent, highly specific, reversible and blood-brain barrier penetrant inhibitor of acetylcholinesterase ( AChE ) , with an IC 50 of 82 nM. (-)-Huperzine A also is non-competitive antagonist of N-methyl-D-aspartate glutamate (NMDA) receptor . (-)-Huperzine A is developed for the research of neurodegenerative diseases, including Alzheimer’s disease.
| Isomeric SMILES | CC=C1[C@@H]2CC3=C([C@]1(CC(=C2)C)N)C=CC(=O)N3 |
|---|---|
| WGK Germany | 3 |
| RTECS | PB9185700 |
| UN Number | 1544 |
| Molecular Weight | 242.32 |
| Reaxy-Rn | 24107487 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24107487&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Specific Rotation[α] | -147° (C=0.5,MeOH) |
|---|---|
| Melt Point(°C) | 232 °C |
| 1. Jianjin GUO, Lu BAI, Chi-Tang HO, Sen GUO, Naisheng BAI. (2023) Chemical characterization, multivariate analysis and in vitro bioactivity evaluation of the roots of Fraxinus mandshurica. CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, [PMID:] [10.1016/j.cjac.2023.100303] |
| 2. Nan Zhao, Dan Liu, Yi Wang, Xiaozhe Zhang, Lihua Zhang. (2022) Screening and identification of anti-acetylcholinesterase ingredients from Tianzhi granule based on ultrafiltration combined with ultra-performance liquid chromatography-mass spectrometry and in silico analysis. JOURNAL OF ETHNOPHARMACOLOGY, [PMID:35973628] [10.1016/j.jep.2022.115641] |
| 3. Peiqi Luo, Liping Wang, Lixia Jiang, Jie Sun, Yafeng Li, Huihui Liu, Caiqiao Xiong, Zongxiu Nie. (2020) Application of Graphdiyne in Surface-Assisted Laser Desorption Ionization Mass Spectrometry. ACS Applied Materials & Interfaces, [PMID:33378159] [10.1021/acsami.0c18280] |
| 4. Liping Zhao, Ge Yang, Linsen Li, Chao Zhu, Yao Ma, Feng Qu. (2020) Aptamer-functionalized magnetic nanoparticles conjugated organic framework for immobilization of acetylcholinesterase and its application in inhibitors screening. ANALYTICA CHIMICA ACTA, [PMID:33218485] [10.1016/j.aca.2020.10.024] |
| 5. Xiao Tian, Sen Guo, Shanshan Zhang, Peisheng Li, Tianyi Wang, Chi-Tang Ho, Min-Hsiung Pan, Naisheng Bai. (2019) Chemical characterization of main bioactive constituents in Paeonia ostii seed meal and GC-MS analysis of seed oil. JOURNAL OF FOOD BIOCHEMISTRY, 44 (1): (e13088). [PMID:31646682] [10.1111/jfbc.13088] |
| 6. Sen Guo, Li Liu, Shanshan Zhang, Chuang Yang, Wenping Yue, Haoan Zhao, Chi-Tang Ho, Junfeng Du, Hai Zhang, Naisheng Bai. (2019) Chemical characterization of the main bioactive polyphenols from the roots of Morus australis (mulberry). Food & Function, 10 (10): (6915-6926). [PMID:31588440] [10.1039/C9FO01457H] |
| 7. Wei Li, Qian Liu, Shimian Cheng, Shanren Li, Yongbiao Zheng. (2019) New Sesquiterpenoids from the Fermented Broth of Termitomyces albuminosus and Their Anti-Acetylcholinesterase Activity. MOLECULES, 24 (16): (2980). [PMID:31426402] [10.3390/molecules24162980] |
| 8. Jiqing Yang, Xiaotong Hu, Jia Xu, Xin Liu, Li Yang. (2018) Single-Step In Situ Acetylcholinesterase-Mediated Alginate Hydrogelation for Enzyme Encapsulation in CE. ANALYTICAL CHEMISTRY, [PMID:29469571] [10.1021/acs.analchem.7b05353] |
| 9. Qiang Fu, Jun Tang, Meng Cui, Zhong Zheng, Zhiqiang Liu, Shuying Liu. (2015) Development of ESI-MS-based continuous enzymatic assay for real-time monitoring of enzymatic reactions of acetylcholinesterase. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, [PMID:25875590] [10.1016/j.jchromb.2015.03.022] |
| 10. Yong-Hao Ye, Cong Li, Jun Yang, Liang Ma, Yu Xiao, Jun Hu, Nasir Ahmed Rajput, Cong-Fen Gao, Ying-Ying Zhang, Ming-Hua Wang. (2014) Construction of an immobilised acetylcholinesterase column and its application in screening insecticidal constituents from Magnolia officinalis. PEST MANAGEMENT SCIENCE, 71 (4): (607-615). [PMID:25228142] [10.1002/ps.3908] |
| 11. Min Wenao, Wang Weiping, Chen Jianrong, Wang Aijun, Hu Zhide. (2012) On-line immobilized acetylcholinesterase microreactor for screening of inhibitors from natural extracts by capillary electrophoresis. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 404 (8): (2397-2405). [PMID:22932810] [10.1007/s00216-012-6333-8] |
| 12. Jianjin Guo, Jing Gao, Yan Guo, Lu Bai, Chi-Tang Ho, Naisheng Bai. (2024) Characterization, multivariate analysis and bioactivity evaluation of coumarins in the bark of Fraxinus mandshurica. FITOTERAPIA, [PMID:38382892] [10.1016/j.fitote.2024.105865] |
| 13. Jianjin Guo, Shaojing Liu, Yan Guo, Lu Bai, Chi-Tang Ho, Naisheng Bai. (2024) Chemical characterization, multivariate analysis and comparison of biological activities of different parts of Fraxinus mandshurica. BIOMEDICAL CHROMATOGRAPHY, 38 (6): (e5861). [PMID:38501361] [10.1002/bmc.5861] |
| 14. Zhao Fengju, Guo Hui, Yang Wei, Guo Lili, Li Jiaxin, Chen Hanqi. (2024) Determination of Acetylcholinesterase Activity Based on Ratiometric Fluorescence Signal Sensing. JOURNAL OF FLUORESCENCE, [PMID:38613708] [10.1007/s10895-024-03703-y] |
| 15. Lv Jie, He Chengcai, Cao Jingcheng, Shuai Qiuyan, Liu Xifang, Li Meng, Lin Yulong. (2024) Gold nanoclusters/manganese dioxide nanosheets hybrid nanozyme with fluorescence and oxidase-like activity for dual-mode detection of acetylcholinesterase and inhibitors screening. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, [PMID:39733176] [10.1007/s00216-024-05712-z] |
| 16. Dai-Xu Wei, Duanfang Cai, Youguo Tan, Kezhi Liu, Jin-Wei Dao, Xiang Li, Aikeremujiang Muheremu. (2024) Poly(3-hydroxybutyrate-co-3-hydroxyvalerate-co-3-hydroxyhexanoate)-based microspheres as a sustained platform for Huperzine A delivery for alzheimer's disease therapy. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, [PMID:39447780] [10.1016/j.ijbiomac.2024.136582] |
| 17. Xin Liu, Irfan Azhar, Habib Khan, Qishu Qu, Miaomiao Tian, Li Yang. (2019) Capillary electrophoresis-immobilized enzyme microreactors for acetylcholinesterase assay with surface modification by highly-homogeneous microporous layer. JOURNAL OF CHROMATOGRAPHY A, [PMID:31443966] [10.1016/j.chroma.2019.460454] |
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