Indibulin - ≥98%(HPLC) , Tubulin inhibitor, CAS No.204205-90-3, Tubulin inhibitor

CAS: 204205-90-3 Cat. No.: I288011 Molecular Weight: 389.83

COA

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Indibulin - ≥98%(HPLC) CAS No(204205-90-3) by Aladdin Scientific

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AVAILABLE TO ORDER

GRADE & PURITY ≥98%(HPLC)

Synonyms

D 24851 | 2-[1-(4-Chlorobenzyl)-1H-indol-3-yl]-2-oxo-N-pyridin-4-ylacetamide | ZIO 301

Storage

Store at -20°C,Desiccated

Shipped In

Ice chest + Ice pads

Specifications Product Properties Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solution Calculators Reviews

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Why this grade

≥98%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -20°C,Desiccated Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Specifications

Synonyms

D 24851 | 2-[1-(4-Chlorobenzyl)-1H-indol-3-yl]-2-oxo-N-pyridin-4-ylacetamide | ZIO 301

Specifications & Purity

≥98%(HPLC)

Biochemical and Physiological Mechanisms

Microtubule destabilizer that blocks tubulin polymerization (IC50= 0.3μM). Blocks cell cycle progression at metaphase and displays antitumor activity against a variety of malignanciesin vitro(IC50values ranging from 0.036 - 0.285μM). Induces complete tumo

Storage

Store at -20°C, Desiccated

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Mechanism of action

Tubulin inhibitor

Purity

≥98%(HPLC)

Product Properties

ALogP	3.9

Names and Identifiers

Pubchem Sid	504750620
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504750620
Canonical Smiles	C1=CC=C2C(=C1)C(=CN2CC3=CC=C(C=C3)Cl)C(=O)C(=O)NC4=CC=NC=C4
IUPAC Name	2-[1-[(4-chlorophenyl)methyl]indol-3-yl]-2-oxo-N-pyridin-4-ylacetamide
InChIKey	SOLIIYNRSAWTSQ-UHFFFAOYSA-N
INCHI	1S/C22H16ClN3O2/c23-16-7-5-15(6-8-16)13-26-14-19(18-3-1-2-4-20(18)26)21(27)22(28)25-17-9-11-24-12-10-17/h1-12,14H,13H2,(H,24,25,28)
Isomeric SMILES	C1=CC=C2C(=C1)C(=CN2CC3=CC=C(C=C3)Cl)C(=O)C(=O)NC4=CC=NC=C4
Molecular Weight	389.83
Reaxy-Rn	9006736
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=9006736&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Indoles and derivatives
    - Subclass N-alkylindoles

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Indoles and derivatives
Subclass	N-alkylindoles
Intermediate Tree Nodes	Not available
Direct Parent	N-alkylindoles
Alternative Parents	Indoles N-arylamides Aryl ketones Chlorobenzenes Substituted pyrroles Pyridines and derivatives Aryl chlorides Vinylogous amides Heteroaromatic compounds Secondary carboxylic acid amides Azacyclic compounds Organopnictogen compounds Organochlorides Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	N-alkylindole - Indole - N-arylamide - Aryl ketone - Chlorobenzene - Halobenzene - Aryl chloride - Aryl halide - Monocyclic benzene moiety - Pyridine - Substituted pyrrole - Benzenoid - Heteroaromatic compound - Pyrrole - Vinylogous amide - Secondary carboxylic acid amide - Carboxamide group - Ketone - Azacycle - Carboxylic acid derivative - Carbonyl group - Organohalogen compound - Organopnictogen compound - Organic oxygen compound - Organic nitrogen compound - Organochloride - Organic oxide - Organonitrogen compound - Hydrocarbon derivative - Organooxygen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as n-alkylindoles. These are compounds containing an indole moiety that carries an alkyl chain at the 1-position.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D Structure

Associated Targets(Human)

A-375 (9258 Activities)

Lot Number	Certificate Type	Date	Item
C2304632	Certificate of Analysis	Dec 12, 2025	I288011
C2304633	Certificate of Analysis	Dec 12, 2025	I288011
C2304673	Certificate of Analysis	Dec 12, 2025	I288011
C2304674	Certificate of Analysis	Dec 12, 2025	I288011
C2304675	Certificate of Analysis	Dec 12, 2025	I288011

Solubility	Solvent:DMSO, Max Conc. mg/mL: 9.75, Max Conc. mM: 25
Molecular Weight	389.800 g/mol
XLogP3	3.900
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	5
Exact Mass	389.093 Da
Monoisotopic Mass	389.093 Da
Topological Polar Surface Area	64.000 Å²
Heavy Atom Count	28
Formal Charge	0
Complexity	558.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1