Ivabradine HCl - 10mM in DMSO , Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 blocker, CAS No.148849-67-6, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 blocker

CAS: 148849-67-6 Cat. No.: I408567 Molecular Weight: 505.05 EC Number: 638-798-3 PubChem CID: 3045381

GRADE & PURITY 10mM in DMSO

Synonyms

S 16257-2 | 3-​[3-​[[[(7S)​-​3,​4-​dimethoxybicyclo[4.2​.0]​octa-​1,​3,​5-​trien-​7-​yl]​methyl]​methylamino]​propyl]​-​1,​3,​4,​5-​tetrahydro-​7,​8-​dimethoxy-​2H-​3-​benzazepin-​2-​one,hydrochloride (1:1)

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Information

Ivabradine HCl Ivabradine HCl (S 16257-2), a new I f inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent.
In vitro

In vivo

Cell Data

cell lines：

Concentrations：

Incubation Time：

Powder Purity:≥99%

Specifications

Synonyms

S 16257-2 | 3-​[3-​[[[(7S)​-​3, ​4-​dimethoxybicyclo[4.2​.0]​octa-​1, ​3, ​5-​trien-​7-​yl]​methyl]​methylamino]​propyl]​-​1, ​3, ​4, ​5-​tetrahydro-​7, ​8-​dimethoxy-​2H-​3-​benzazepin-​2-​one, hydrochloride (1:1)

Specifications & Purity

10mM in DMSO

Biochemical and Physiological Mechanisms

Ivabradine HCl (S 16257-2), a new I_f inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent.

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

BLOCKER

Mechanism of action

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 blocker

Names and Identifiers

• Isomeric SMILES: CN(CCCN1CCC2=CC(=C(C=C2CC1=O)OC)OC)C[C@H]3CC4=CC(=C(C=C34)OC)OC.Cl
• WGK Germany: 3
• PubChem CID: 3045381
• Molecular Weight: 505.05

Chemical and Physical Properties

• Specific Rotation[α]: 7° (C=1,DMSO)
• Melt Point(°C): 140 °C

References

1. Guo-Xuan Liu, Fan Diao, Guang Lu, Qiang Zheng, Bin Fu, Hua-Chen Jiao, Ke-Zhou Wang, Dong-Hai Liu.  (2025)  Alectinib causes sinus bradycardia by suppressing L-type calcium current in sinus node.  EUROPEAN JOURNAL OF PHARMACOLOGY,      [PMID:40118326] [10.1016/j.ejphar.2025.177527]