Jedi2 - Moligand™, ≥98%(HPLC) , Activator of Piezo1, CAS No.651005-90-2, Activator of Piezo1

CAS: 651005-90-2 Cat. No.: J288068 Molecular Weight: 208.23 EC Number: 111-296-7

GRADE & PURITY Moligand™, ≥98%(HPLC)

Synonyms

2-Methyl-5-(thien-2-yl)-3-furoic acid | HMS1431A19 | GLXC-25617 | 3-Furancarboxylic acid, 2-methyl-5-(2-thienyl)- | E78747 | GTPL10111 | 2-methyl-5-(2-thienyl)-3-furoic acid | 2-methyl-5-thiophen-2-ylfuran-3-carboxylic acid | MB01892 | IDI1_011406 | 7R2DP

Storage

Store at 2-8°C

Shipped In

Wet ice

Specifications

Synonyms

2-Methyl-5-(thien-2-yl)-3-furoic acid | HMS1431A19 | GLXC-25617 | 3-Furancarboxylic acid, 2-methyl-5-(2-thienyl)- | E78747 | GTPL10111 | 2-methyl-5-(2-thienyl)-3-furoic acid | 2-methyl-5-thiophen-2-ylfuran-3-carboxylic acid | MB01892 | IDI1_011406 | 7R2DP

Specifications & Purity

Moligand™, ≥98%(HPLC)

Biochemical and Physiological Mechanisms

Jedi2 is an activator of the mechanosensitive Piezo1 channel that binds at a different place from Yoda1. It exhibits long-range allosteric gating, activating Piezo1 through the extracellular side of its peripheral blade-like structure rather than the C-te

Storage

Store at 2-8°C

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

ACTIVATOR

Mechanism of action

Activator of Piezo1

Purity

≥98%(HPLC)

Names and Identifiers

• Pubchem Sid: 504762176
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504762176
• Canonical Smiles: CC1=C(C=C(O1)C2=CC=CS2)C(=O)O
• IUPAC Name: 2-methyl-5-thiophen-2-ylfuran-3-carboxylic acid
• InChIKey: YXDCRSXNEOKXDE-UHFFFAOYSA-N
• INCHI: 1S/C10H8O3S/c1-6-7(10(11)12)5-8(13-6)9-3-2-4-14-9/h2-5H,1H3,(H,11,12)
• Isomeric SMILES: CC1=C(C=C(O1)C2=CC=CS2)C(=O)O
• Alternate CAS: 651005-90-2
• Molecular Weight: 208.23
• Reaxy-Rn: 39751521
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=39751521&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organoheterocyclic compounds
    • Class Furans
      • Subclass Furoic acid and derivatives

• Kingdom: Organic compounds
• Superclass: Organoheterocyclic compounds
• Class: Furans
• Subclass: Furoic acid and derivatives
• Intermediate Tree Nodes: Not available
• Direct Parent: Furoic acids
• Alternative Parents: Furan-3-carboxylic acids Thiophenes Heteroaromatic compounds Oxacyclic compounds Monocarboxylic acids and derivatives Carboxylic acids Organooxygen compounds Organic oxides Hydrocarbon derivatives
• Molecular Framework: Aromatic heteromonocyclic compounds
• Substituents: Furan-3-carboxylic acid - Furan-3-carboxylic acid or derivatives - Furoic acid - Heteroaromatic compound - Thiophene - Oxacycle - Monocarboxylic acid or derivatives - Carboxylic acid - Carboxylic acid derivative - Organic oxygen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Aromatic heteromonocyclic compound
• Description: This compound belongs to the class of organic compounds known as furoic acids. These are organic compounds containing a furoic acid moiety, with a structure characterized by a furan ring bearing a carboxylic acid group at the C2 or C3 carbon atom.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

PIEZO1 Tchem Piezo-type mechanosensitive ion channel component 1 (1 Activities)

Discover Target: PIEZO1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Solvent:DMSO, Max Conc. mg/mL: 20.82, Max Conc. mM: 100; Solvent:ethanol, Max Conc. mg/mL: 20.82, Max Conc. mM: 100
• Molecular Weight: 208.240 g/mol
• XLogP3: 2.300
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 208.019 Da
• Monoisotopic Mass: 208.019 Da
• Topological Polar Surface Area: 78.700 Ų
• Heavy Atom Count: 14
• Formal Charge: 0
• Complexity: 231.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1