JNJ-26854165 (Serdemetan) - ≥98% , CAS No.881202-45-5

CAS: 881202-45-5 Cat. No.: S126246 Molecular Weight: 328.42 PubChem CID: 11609586

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JNJ-26854165 (Serdemetan) - ≥98% CAS No(881202-45-5) by Aladdin Scientific

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AVAILABLE TO ORDER

GRADE & PURITY ≥98%

Synonyms

CCG-264846 | AS-56263 | NCGC00263171-01 | 2-(Furan-2-yl)thiazolidine-4-carboxylicacid | JNJ-26854165 (Serdemetan) | FT-0689750 | N1-(2-(1H-Indol-3-yl)ethyl)-N4-(pyridin-4-yl)benzene-1,4-diamine | PBANXRNIXGEHPZ-UHFFFAOYSA-N | JNJ 26854165 | BCP02124 | A86

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview Specifications Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Documents & Articles Citations of This Product References Solution Calculators Reviews

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Why this grade

≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

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Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

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Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

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Literature proof

Cited in 1 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

JNJ-26854165 (Serdemetan) acts as a HDM2 ubiquitin ligase antagonist and also induces early apoptosis in p53 wild-type cells, inhibits cellular proliferation followed by delayed apoptosis in the absence of functional p53.
A p53 activator and HDM2 ubiquitin ligase (MDM2) inhibitor

Specifications

Synonyms

CCG-264846 | AS-56263 | NCGC00263171-01 | 2-(Furan-2-yl)thiazolidine-4-carboxylicacid | JNJ-26854165 (Serdemetan) | FT-0689750 | N1-(2-(1H-Indol-3-yl)ethyl)-N4-(pyridin-4-yl)benzene-1, 4-diamine | PBANXRNIXGEHPZ-UHFFFAOYSA-N | JNJ 26854165 | BCP02124 | A86

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

JNJ 26854165 is a tryptamine derivative which activates p53 and acts as an HDM2 ubiquitin ligase(MDM2) inhibitor. JNJ 26854165 inhibits cell growth and induces apoptosis in leukemia cell lines. JNJ 26854165 is an MDM2 inhibitor which can inhibit the inter

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥98%

Names and Identifiers

Pubchem Sid	504766586
Pubchem Sid Url	https://pubchem.ncbi.nlm.nih.gov/substance/504766586
Canonical Smiles	C1=CC=C2C(=C1)C(=CN2)CCNC3=CC=C(C=C3)NC4=CC=NC=C4
IUPAC Name	1-N-[2-(1H-indol-3-yl)ethyl]-4-N-pyridin-4-ylbenzene-1,4-diamine
InChIKey	CEGSUKYESLWKJP-UHFFFAOYSA-N
INCHI	1S/C21H20N4/c1-2-4-21-20(3-1)16(15-24-21)9-14-23-17-5-7-18(8-6-17)25-19-10-12-22-13-11-19/h1-8,10-13,15,23-24H,9,14H2,(H,22,25)
Isomeric SMILES	C1=CC=C2C(=C1)C(=CN2)CCNC3=CC=C(C=C3)NC4=CC=NC=C4
PubChem CID	11609586
Molecular Weight	328.42

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Indoles and derivatives
    - Subclass Tryptamines and derivatives

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Indoles and derivatives
Subclass	Tryptamines and derivatives
Intermediate Tree Nodes	Not available
Direct Parent	Tryptamines and derivatives
Alternative Parents	3-alkylindoles Phenylalkylamines Aniline and substituted anilines Secondary alkylarylamines Aminopyridines and derivatives Substituted pyrroles Heteroaromatic compounds Azacyclic compounds Organopnictogen compounds Hydrocarbon derivatives
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Tryptamine - 3-alkylindole - Indole - Aniline or substituted anilines - Phenylalkylamine - Aminopyridine - Aralkylamine - Secondary aliphatic/aromatic amine - Benzenoid - Monocyclic benzene moiety - Substituted pyrrole - Pyridine - Heteroaromatic compound - Pyrrole - Azacycle - Secondary amine - Amine - Organonitrogen compound - Organic nitrogen compound - Organopnictogen compound - Hydrocarbon derivative - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as tryptamines and derivatives. These are compounds containing the tryptamine backbone, which is structurally characterized by an indole ring substituted at the 3-position by an ethanamine.
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D Structure

Associated Targets(Human)

5637 (630 Activities)

Lot Number	Certificate Type	Date	Item
I2205362	Certificate of Analysis	Mar 11, 2026	S126246
I2205363	Certificate of Analysis	Mar 11, 2026	S126246
I2205396	Certificate of Analysis	Mar 11, 2026	S126246
I2205397	Certificate of Analysis	Mar 11, 2026	S126246
I2205398	Certificate of Analysis	Mar 11, 2026	S126246

Solubility	DMSO ≥64mg/mL Water <1.2mg/mL Ethanol ≥1.8mg/mL；insoluble in EtOH; insoluble in H2O; ≥14.8 mg/mL in DMSO
Molecular Weight	328.400 g/mol
XLogP3	4.600
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	6
Exact Mass	328.169 Da
Monoisotopic Mass	328.169 Da
Topological Polar Surface Area	52.700 Å²
Heavy Atom Count	25
Formal Charge	0
Complexity	387.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1