10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 4 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
JSH-23 JSH-23 is an inhibitor of NF-κB transcriptional activity with IC50 of 7.1 μM in RAW 264.7 cell line.
In vitro
JSH-23 inhibits LPS-induced nuclear translocation of NF-κB p65 without affecting IκBα degradation. JSH-23 inhibits LPS-induced apoptotic chromatin condensation, while does not show significant cytotoxic effects on the RAW 264.7 cells at <100 μM. JSH-23 also decreases NO production and neuronal migration in LPS activated cultures primary cultures from developing mouse cerebellum. Moreover, JSH-23 augments cisplatin cytotoxicity in ovarian cancer cells with CI values ranging from 0.35 to 0.85.
In vivo
JSH-23 (3 mg/kg) significantly reverses the nerve conduction and nerve blood flow deficits by decreasing neuroinflammation and improving antioxidant defence in diabetic rats.
Cell Data
cell lines：
Concentrations：~300 μM
Incubation Time：24 hours
Powder Purity:≥99%
| Isomeric SMILES | CC1=CC(=C(C=C1)NCCCC2=CC=CC=C2)N |
|---|---|
| WGK Germany | 3 |
| Molecular Weight | 240.34 |
| Reaxy-Rn | 24398255 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=24398255&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Melt Point(°C) | 103 °C |
|---|
| 1. Jin Zhang, Changsong Wang, Hongliang Wang, Xueting Li, Jingjing Xu, Kaijiang Yu. (2021) Loganin alleviates sepsis-induced acute lung injury by regulating macrophage polarization and inhibiting NLRP3 inflammasome activation. INTERNATIONAL IMMUNOPHARMACOLOGY, [PMID:33744777] [10.1016/j.intimp.2021.107529] |
| 2. Min Xiao-li, Shi Ying, Xu Ying, Li Yu-ye, Dong You-kang, Chen Fei-xiong, Chen Quan-ming, Sun Yu-long, Liao Rui, Wang Jia-ping. (2025) Mechanism of Sirtuin1-Mediated Deacetylation of p65-Mediated Ferroptosis of Hippocampal Neurons in Cerebral Injury after Cardiopulmonary Resuscitation in Rats. NEUROCHEMICAL RESEARCH, 50 (1): (1-17). [PMID:39751951] [10.1007/s11064-024-04297-4] |
| 3. Waimei Si, Xin Li, Bei Jing, Shiquan Chang, Yachun Zheng, Zhenni Chen, Guoping Zhao, Di Zhang. (2023) Stigmasterol regulates microglial M1/M2 polarization via the TLR4/NF-κB pathway to alleviate neuropathic pain. PHYTOTHERAPY RESEARCH, [PMID:37871970] [10.1002/ptr.8039] |
| 4. Yujie Jia, Yu Tong, Lianqiu Min, Yanrong Li, Yan Cheng. (2021) Protective effects of oridonin against cerebral ischemia/reperfusion injury by inhibiting the NLRP3 inflammasome activation. TISSUE & CELL, [PMID:33676236] [10.1016/j.tice.2021.101514] |
