K48-Linked Tetra-Ubiquitin - BioReagent,for protein analysis,≥95%(WB),See COA

Cat. No.: K1518272

GRADE & PURITY BioReagent, for Protein analysis, ≥95%(WB), See COA

Synonyms

K48 Tetra-Ubiquitin | K48-Linked Tetra-Ubiquitin | K48-linked tetra ubiquitin (Ub4)

Storage

Store at -80°C,Avoid repeated freezing and thawing

Shipped In

Dry ice packs + Cold packs

Application

846

Overview

  Poly-ubiquitylation of target proteins through linkage at K48, is now the most throughly studied of the various chain linkages, and we once considered the hallmark of this post-translational modification. It is now clear that many, if not all, poly-Ub chain topologies likely play distinct and important roles in regulating cellular processes. Nevertheless, K48 linkage remains a critical pathway for the cells to maintain homeostasis through proteolytic degradation, and as such remains very intriguing for the study of DUBs that play a role in the degradation, as well as the proteasome itself.

  These tetra-ubiquitin chains generated from the enzymatic linkage (E2-25K) of wild-type ubiquitin through lysine 48. The most distal ubiquitin contains an arginine substitution for a lysine at position 48, limiting chain length.

Application

Investigation of DUB linkage specificity

Product Information

1. Species: Human

2. Expression System: E. coli

3. Tag: None

4. Purity: > 95% by Western blot analysis

5. Molecular Weight: 34,233.4 Da

6. Physical State: Liquid

7. Buffer: 20 mM Tris-HCl, pH 7.5, 0.15 M NaCl, 1 mM EDTA

8. Quantity: 25 μg

9. Solubility: >1 mg/mL

10. Storage: -80℃. Avoid repeated freeze/thaw cycles.

Western blot analysis 

RP-HPLC Profile

Specifications

Synonyms

K48 Tetra-Ubiquitin | K48-Linked Tetra-Ubiquitin | K48-linked tetra ubiquitin (Ub4)

Specifications & Purity

BioReagent, for protein analysis, ≥95%(WB), See COA

Stability And Storage

Store at -80℃ long term (12 months)

Storage

Store at -80°C, Avoid repeated freezing and thawing

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

BioReagent, for Protein analysis

Purity

≥95%(WB)