L-Glutamic acid hydrochloride - ≥98% , CAS No.138-15-8

CAS: 138-15-8 Cat. No.: G113196 Molecular Weight: 183.59 Beilstein Registry Number: 3565569 EC Number: 205-315-9

GRADE & PURITY ≥98%

Synonyms

GLUTAMIC ACID HYDROCHLORIDE [HSDB] | NCGC00256673-01 | Pepsdol | SMR001230835 | Acidothyn | Glutamic acid, L-, hydrochloride | M0C2SP444T | G0060 | REGID_for_CID_2723891 | SCHEMBL176819 | UNII-M0C2SP444T | Hypochylin (TN) | Aciglumin | Aclor | Clorhidrato

Storage

Store at 2-8°C,Argon charged

Shipped In

Wet ice

Overview

L-glutamate is the major excitatory neurotransmitter in mammalian central nervous system (CNS). It interacts with membrane bound glutamate receptors

L-Glutamic acid hydrochloride has been used as a nutrient additive to study the effect of increased dissolved inorganic nitrogen (DIN) on the uptake of dissolved organic nitrogen (DON) and dissolved organic carbon (DOC), in a nitrogen-limited headwater forest stream

Specifications

Synonyms

GLUTAMIC ACID HYDROCHLORIDE [HSDB] | NCGC00256673-01 | Pepsdol | SMR001230835 | Acidothyn | Glutamic acid, L-, hydrochloride | M0C2SP444T | G0060 | REGID_for_CID_2723891 | SCHEMBL176819 | UNII-M0C2SP444T | Hypochylin (TN) | Aciglumin | Aclor | Clorhidrato

Specifications & Purity

≥98%

Biochemical and Physiological Mechanisms

L-glutamate plays key roles in development, learning, memory, plasticity and cognition. It plays crucial role in the pathogenesis of neuropathological diseases such as epilepsy, schizophrenia, stroke, ischemia, ALS (amyotrophic lateral sclerosis), Hunting

Storage

Store at 2-8°C, Argon charged

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98%

Names and Identifiers

• Pubchem Sid: 504760827
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/504760827
• Canonical Smiles: C(CC(=O)O)C(C(=O)O)N.Cl
• IUPAC Name: (2S)-2-aminopentanedioic acid;hydrochloride
• InChIKey: RPAJSBKBKSSMLJ-DFWYDOINSA-N
• INCHI: 1S/C5H9NO4.ClH/c6-3(5(9)10)1-2-4(7)8;/h3H,1-2,6H2,(H,7,8)(H,9,10);1H/t3-;/m0./s1
• Isomeric SMILES: C(CC(=O)O)[C@@H](C(=O)O)N.Cl
• WGK Germany: 3
• Molecular Weight: 183.59
• Beilstein: 3565569
• Reaxy-Rn: 4155096
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=4155096&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives
            • Level7 Glutamic acid and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives
• Direct Parent: Glutamic acid and derivatives
• Alternative Parents: L-alpha-amino acids Amino fatty acids Dicarboxylic acids and derivatives Amino acids Carboxylic acids Organopnictogen compounds Organic oxides Monoalkylamines Hydrochlorides Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Glutamic acid or derivatives - Alpha-amino acid - L-alpha-amino acid - Amino fatty acid - Dicarboxylic acid or derivatives - Fatty acid - Fatty acyl - Amino acid - Carboxylic acid - Hydrochloride - Organic oxide - Primary amine - Organooxygen compound - Organonitrogen compound - Primary aliphatic amine - Organopnictogen compound - Carbonyl group - Organic oxygen compound - Amine - Organic nitrogen compound - Hydrocarbon derivative - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as glutamic acid and derivatives. These are compounds containing glutamic acid or a derivative thereof resulting from reaction of glutamic acid at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Associated Targets(Human)

KDM4A Tchem Lysine-specific demethylase 4A (52245 Activities)

Discover Target: KDM4A

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

Discover Target: EHMT2

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)

Discover Target: ATAD5

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

BAZ2B Tchem Bromodomain adjacent to zinc finger domain protein 2B (56204 Activities)

Discover Target: BAZ2B

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Associated Targets(non-human)

TGR Thioredoxin glutathione reductase (28579 Activities)

Discover Target: TGR

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

nfo Endonuclease 4 (425 Activities)

Discover Target: nfo

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

Mechanisms of Action

Chemical and Physical Properties

• Solubility: Soluble in water (490 g/L).
• Sensitivity: Moisture sensitive
• Specific Rotation[α]: 24 ° (C=6, H2O)
• Melt Point(°C): 202-213°C
• Molecular Weight: 183.590 g/mol
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 183.03 Da
• Monoisotopic Mass: 183.03 Da
• Topological Polar Surface Area: 101.000 Ų
• Heavy Atom Count: 11
• Formal Charge: 0
• Complexity: 145.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

XLogP3

References

1. Yong Pan, Ning Mu, Bo Liu, Bingqing Cao, Wen Wang, Liu Yang.  (2018)  A Novel Surface Acoustic Wave Sensor Array Based on Wireless Communication Network.  SENSORS,  18  (9): (2977).  [PMID:30200649] [10.3390/s18092977]

2. Xueqiang Chen, Fan Yang, Shiwei Zhao, Xinran Wei, Jiameng Xu, Yunzhe Li, Guanjun Nan, Zhimin Luo, Aiguo Zeng.  (2024)  An Electrochemical Sensor Based on Simple Nano-Modification for Sensitive Detection of Ofloxacin Residue in Animal Derived Food.  JOURNAL OF THE ELECTROCHEMICAL SOCIETY,      [PMID:] [10.1149/1945-7111/ad2cbb]

3. Peng Du, Yongjian Xu, Jian Wang, Lulu Ning, Xudong Wei, Miaomiao Zhang.  (2025)  Fabricating a novel lignin@modified-cellulose-Fiber composite filter layer via layer-by-layer assembly for personal protection filtration management.  INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,      [PMID:41072684] [10.1016/j.ijbiomac.2025.148187]

4. Peng Du, Yongjian Xu, Meng Zhu, Jian Wang, Lulu Ning, Yuheng Zhang.  (2025)  Cellulose-based triboelectric nanogenerator with efficient filtering performance for medical protection filtration equipment.  CHEMICAL ENGINEERING JOURNAL,      [PMID:] [10.1016/j.cej.2025.170522]