L-Serine - PharmPure™, USP, JP, Ph.Eur. , CAS No.56-45-1

CAS: 56-45-1 Cat. No.: GMP1527800 Molecular Weight: 105.09 Beilstein Registry Number: 1721404 EC Number: 200-274-3

GRADE & PURITY PharmPure™, USP, JP, Ph.Eur.

Storage

Room temperature

Shipped In

Normal

Overview

L-Serine has been used as a supplement in a medium to culture Chinese hamster ovary TF 70R cell line and in mouse embryonic fibroblast (MEF)-media.

Specifications

Specifications & Purity

PharmPure™, USP, JP, Ph.Eur.

Biochemical and Physiological Mechanisms

L-Serine is a non-essential amino acid that acts as a precursor for nucleotide synthesis. It has roles in the development and function of the central nervous system.Precursor of glycine by serine hydroxymethyltransferase.

Storage

Room temperature

Shipped In

Normal

Grade

JP, Ph.Eur., PharmPure™, USP

Names and Identifiers

• Canonical Smiles: C(C(C(=O)O)N)O
• IUPAC Name: (2S)-2-amino-3-hydroxypropanoic acid
• InChIKey: MTCFGRXMJLQNBG-REOHCLBHSA-N
• INCHI: 1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
• Isomeric SMILES: C([C@@H](C(=O)O)N)O
• WGK Germany: 1
• RTECS: VT8100000
• Molecular Weight: 105.09
• Beilstein: 1721404
• Reaxy-Rn: 1721402
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1721402&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Carboxylic acids and derivatives
      • Subclass Amino acids, peptides, and analogues
        • Level5 Amino acids and derivatives
          • Level6 Alpha amino acids and derivatives
            • Level7 Serine and derivatives

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Carboxylic acids and derivatives
• Subclass: Amino acids, peptides, and analogues
• Intermediate Tree Nodes: Amino acids and derivatives - Alpha amino acids and derivatives
• Direct Parent: Serine and derivatives
• Alternative Parents: L-alpha-amino acids Beta hydroxy acids and derivatives Amino acids Monocarboxylic acids and derivatives Carboxylic acids Primary alcohols Organopnictogen compounds Organic oxides Monoalkylamines Hydrocarbon derivatives Carbonyl compounds
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Serine or derivatives - Alpha-amino acid - L-alpha-amino acid - Beta-hydroxy acid - Hydroxy acid - Amino acid - Carboxylic acid - Monocarboxylic acid or derivatives - Alcohol - Primary amine - Primary alcohol - Organooxygen compound - Organonitrogen compound - Hydrocarbon derivative - Primary aliphatic amine - Organic oxide - Organopnictogen compound - Carbonyl group - Organic oxygen compound - Amine - Organic nitrogen compound - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as serine and derivatives. These are compounds containing serine or a derivative thereof resulting from reaction of serine at the amino group or the carboxy group, or from the replacement of any hydrogen of glycine by a heteroatom.
• External Descriptors: Common amino acids

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: H2O: 50mg/mL
• Specific Rotation[α]: 15° (C=10,HCl(1+5))
• Melt Point(°C): 228°C(dec.)(lit.)
• Molecular Weight: 105.090 g/mol
• XLogP3: -3.100
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 105.043 Da
• Monoisotopic Mass: 105.043 Da
• Topological Polar Surface Area: 83.600 Ų
• Heavy Atom Count: 7
• Formal Charge: 0
• Complexity: 72.600
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

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42. Dan Zhao, Jingjing Huang, Juan Li, Xiao Ma, Fang Wang, Honglei Zhang, Jiaze Xie, Jian Sun, Chuanxia Chen.  (2023)  Ultrasensitive colorimetric and fluorescent dual-readout assay for D-penicillamine based on the chloride boosted oxidative ability of copper ions.  MICROCHEMICAL JOURNAL,      [PMID:] [10.1016/j.microc.2023.108535]

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44. Lin Huang, Weixia Zhang, Difei Tong, Lingzheng Lu, Weishang Zhou, Dandan Tian, Guangxu Liu, Wei Shi.  (2023)  Triclosan and triclocarban weaken the olfactory capacity of goldfish by constraining odorant recognition, disrupting olfactory signal transduction, and disturbing olfactory information processing.  WATER RESEARCH,      [PMID:36801581] [10.1016/j.watres.2023.119736]

45. Chengxiang Chu, Xianfeng Wang, Yuanyi Deng, Yi Ma, Chengyue Zou, Mei Yang, Huibo Luo, Danqun Huo, Changjun Hou.  (2023)  Discrimination of Chinese green tea according to tea polyphenols using fluorescence sensor array based on Tb (III) and Eu (III) doped Zr (IV) metal–organic frameworks.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:36736046] [10.1016/j.saa.2023.122380]

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53. Sun Yanli, Wang Qin, Liu Jin, Zhao Zuoping, Li Lihua, Liu Zhifeng, Lu Jiufu, Jin Lingxia, Zhang Shengrui.  (2022)  Ratiometric Sensing of Intracellular pH Based on Dual Emissive Carbon Dots.  JOURNAL OF FLUORESCENCE,  33  (2): (653-661).  [PMID:36480126] [10.1007/s10895-022-03107-w]

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55. Jie Wang, Chenglong Zhao, Feijin Zhou, Hui Lu, Zhenhong Huang, Cheng Yao, Chan Song.  (2022)  Dual mimic enzyme properties of Fe nanoparticles embedded in two-dimensional carbon nanosheets for colorimetric detection of biomolecules.  ANALYST,  148  (1): (146-152).  [PMID:36475531] [10.1039/D2AN01704K]

56. Baole Zhang, Wanglong Xu, Chuanlong Yin, Yangming Tang.  (2022)  Characterization of low-level D-amino acid isomeric impurities of Semaglutide using liquid chromatography-high resolution tandem mass spectrometry.  JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS,      [PMID:36462248] [10.1016/j.jpba.2022.115164]

57. Lin Yuan, Lei Jiang, Ze Liu, Yingying Xiang, Fei Song, Yujiao Tu.  (2022)  Selective and sensitive simultaneous detection of tartrazine and Hg2+ based on N-doped yellow-green fluorescent carbon dots.  DYES AND PIGMENTS,      [PMID:] [10.1016/j.dyepig.2022.110893]

58. Meijuan Zhang, Jian Cao, Cuiping Huang, Mingming Liu, Yanan Li, Chuanxiao Wang, Yajing Tu.  (2022)  A fluorescent molecular sensor based on 1,8-naphthalimide for sensitive and rapid detection of human serum albumin.  DYES AND PIGMENTS,      [PMID:] [10.1016/j.dyepig.2022.110867]

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60. Wang Xin, Li Longwen, Li Lihua, Bu Tong, Yang Kairong, Xia Junfang, Sun Xinyu, Jiang Hong, Wang Li.  (2022)  Tris(bipyridine)ruthenium(II)-functionalized metal–organic frameworks for the ratiometric fluorescence determination of aluminum ions.  MICROCHIMICA ACTA,  189  (11): (1-10).  [PMID:36190561] [10.1007/s00604-022-05504-1]

61. Lei Jiang, Lin Yuan, Ze Liu, Yingying Xiang, Fei Song, Lifen Meng, Yujiao Tu.  (2022)  Facile hydrothermal synthesis and purification of fluorescent carbon dots for food colorant tartrazine detection based on a dual-mode nanosensor.  Analytical Methods,  14  (41): (4127-4132).  [PMID:36222124] [10.1039/D2AY01140A]

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63. Peng Fangfang, Zhou Xin, Cheng Wanmin, Ma Jimei, Jiang Hong.  (2022)  A Carbon Dots Probe for Specific Determination of Cysteine based on Inner Filter Effect.  JOURNAL OF ANALYTICAL CHEMISTRY,  77  (9): (1141-1146).  [PMID:] [10.1134/S1061934822090039]

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65. Guo-Qi Zhang, Wei-Wu, Yu-Han Shi, Yang Zhao, Zhi-Hong Xu.  (2022)  Flow injection spectrophotometric determination total antioxidant capacity in human serum samples based on response surface methodology to optimize synthesized peroxidase-like activity carbon dots.  SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY,      [PMID:36088741] [10.1016/j.saa.2022.121832]

66. Hang Zhang, Jun Jiang Luo, Zhe Sun, Hao Lin Zou, Hong Qun Luo, Nian Bing Li, Bang Lin Li.  (2022)  Hydrogels allow the precise growth tracking of plasmonic gold nanoparticles for mercury analysis.  Journal of Materials Chemistry C,  10  (39): (14508-14516).  [PMID:] [10.1039/D2TC02483G]

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75. Guobin Mao, Guoqiang Wu, Minghai Chen, Chuang Yan, Jingya Tang, Yingxin Ma, Xian-En Zhang.  (2022)  Synthesis of Dual-Emitting CdZnSe/Mn:ZnS Quantum Dots for Sensing the pH Change in Live Cells.  ANALYTICAL CHEMISTRY,      [PMID:35466670] [10.1021/acs.analchem.1c04811]

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77. Haining Song, Haifeng Zhou, Qianqian Zhuang, Zexin Li, Fenglei Sun, Zhenlei Yuan, Youxin Lou, Guangjun Zhou, Yujun Zhao.  (2022)  IFE based nanosensor composed of UCNPs and Fe(II)-phenanthroline for detection of hypochlorous acid and periodic acid.  JOURNAL OF RARE EARTHS,      [PMID:] [10.1016/j.jre.2022.04.005]

78. Hongyu Chen, Huimeng Zheng, Wen Li, Qingfeng Li, Bin Hu, Nan Pang, Fengshou Tian, Lin Jin.  (2022)  Ultrafast synthesized monometallic nanohybrids as an efficient quencher and recognition antenna of upconversion nanoparticles for the detection of xanthine with enhanced sensitivity and selectivity.  TALANTA,      [PMID:35427950] [10.1016/j.talanta.2022.123471]

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