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Calcium release-activated calcium channel protein 1 (ORAI1)

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  1. YM-58483 (BTP2）, Channel blocker of TRPC3;Channel blocker of TRPC5;Activator of TRPM4
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    YM-58483 (BTP2）, Channel blocker of TRPC3;Channel blocker of TRPC5;Activator of TRPM4
    CAS: 223499-30-7 EC Number: 636-569-2 PubChem CID: 2455 Formula: C15H9F6N5OS Molecular Weight: 421.32
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: Y276423
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    Technical Identifiers
    IUPAC Name
    N-[4-[3,5-bis(trifluoromethyl)pyrazol-1-yl]phenyl]-4-methylthiadiazole-5-carboxamide
    SMILES
    CC1=C(SN=N1)C(=O)NC2=CC=C(C=C2)N3C(=CC(=N3)C(F)(F)F)C(F)(F)F
    InChIKey
    XPRZIORDEVHURQ-UHFFFAOYSA-N
    InChI
    1S/C15H9F6N5OS/c1-7-12(28-25-23-7)13(27)22-8-2-4-9(5-3-8)26-11(15(19,20)21)6-10(24-26)14(16,17)18/h2-6H,1H3,(H,22,27)
    Synonyms
    HMS3648I22 | AS-16763 | CRAC Channel Inhibitor, BTP2 | SR-01000644222-3 | NCGC00344111-03 | AC-35791 | HMS3886H10 | I...
  2. Pyr3, Channel blocker of TRPC3
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    Pyr3, Channel blocker of TRPC3
    CAS: 1160514-60-2 PubChem CID: 56964346 Formula: C16H11Cl3F3N3O3 Molecular Weight: 456.64
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: P275699
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    IUPAC Name
    ethyl 1-[4-(2,3,3-trichloroprop-2-enoylamino)phenyl]-5-(trifluoromethyl)pyrazole-4-carboxylate
    SMILES
    CCOC(=O)C1=C(N(N=C1)C2=CC=C(C=C2)NC(=O)C(=C(Cl)Cl)Cl)C(F)(F)F
    InChIKey
    RZHGONNSASQOAY-UHFFFAOYSA-N
    InChI
    1S/C16H11Cl3F3N3O3/c1-2-28-15(27)10-7-23-25(12(10)16(20,21)22)9-5-3-8(4-6-9)24-14(26)11(17)13(18)19/h3-7H,2H2,1H3,(H,24,26)
    Synonyms
    J-003374 | AKOS024457787 | 1-[4-[(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4...
  3. CM 4620, Channel blocker of Orai1;Channel blocker of Orai2
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    CM 4620, Channel blocker of Orai1;Channel blocker of Orai2
    CAS: 1713240-67-5 Formula: C19H11ClF3N3O3 Molecular Weight: 421.76
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    In Stock Item #: C413652
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    IUPAC Name
    N-[5-(6-chloro-2,2-difluoro-1,3-benzodioxol-5-yl)pyrazin-2-yl]-2-fluoro-6-methylbenzamide
    SMILES
    CC1=C(C(=CC=C1)F)C(=O)NC2=NC=C(N=C2)C3=CC4=C(C=C3Cl)OC(O4)(F)F
    InChIKey
    QQMKTHUGOQDEIL-UHFFFAOYSA-N
    InChI
    1S/C19H11ClF3N3O3/c1-9-3-2-4-12(21)17(9)18(27)26-16-8-24-13(7-25-16)10-5-14-15(6-11(10)20)29-19(22,23)28-14/h2-8H,1H3,(H,25,26,27)
    Synonyms
    BS-15636 | CM 4620 | C73294 | BDBM50575336 | SCHEMBL18038390 | 564AW1RR37 | SB18686 | AC-35758 | CM4620 | CM-4620 | N...
  4. YM-58483 (BTP2）, Channel blocker of TRPC3;Channel blocker of TRPC5;Activator of TRPM4
    Wish List Compare
    YM-58483 (BTP2）, Channel blocker of TRPC3;Channel blocker of TRPC5;Activator of TRPM4
    CAS: 223499-30-7 EC Number: 636-569-2 PubChem CID: 2455 Formula: C15H9F6N5OS Molecular Weight: 421.32
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    In Stock Item #: Y422686
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    Technical Identifiers
    IUPAC Name
    N-[4-[3,5-bis(trifluoromethyl)pyrazol-1-yl]phenyl]-4-methylthiadiazole-5-carboxamide
    SMILES
    CC1=C(SN=N1)C(=O)NC2=CC=C(C=C2)N3C(=CC(=N3)C(F)(F)F)C(F)(F)F
    InChIKey
    XPRZIORDEVHURQ-UHFFFAOYSA-N
    InChI
    1S/C15H9F6N5OS/c1-7-12(28-25-23-7)13(27)22-8-2-4-9(5-3-8)26-11(15(19,20)21)6-10(24-26)14(16,17)18/h2-6H,1H3,(H,22,27)
    Synonyms
    HMS3648I22 | AS-16763 | CRAC Channel Inhibitor, BTP2 | SR-01000644222-3 | NCGC00344111-03 | AC-35791 | HMS3886H10 | I...
  5. no_selection
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    CM4620, Channel blocker of Orai1;Channel blocker of Orai2
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    Out of Stock Item #: C608608
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    Technical Identifiers
    IUPAC Name
    N-[5-(6-chloro-2,2-difluoro-1,3-benzodioxol-5-yl)pyrazin-2-yl]-2-fluoro-6-methylbenzamide
    SMILES
    Clc1cc2OC(Oc2cc1c1ncc(nc1)NC(=O)c1c(C)cccc1F)(F)F
    InChIKey
    QQMKTHUGOQDEIL-UHFFFAOYSA-N
    InChI
    1S/C19H11ClF3N3O3/c1-9-3-2-4-12(21)17(9)18(27)26-16-8-24-13(7-25-16)10-5-14-15(6-11(10)20)29-19(22,23)28-14/h2-8H,1H3,(H,25,26,27)
    Synonyms
    BS-15636 | CM 4620 | C73294 | BDBM50575336 | SCHEMBL18038390 | 564AW1RR37 | SB18686 | AC-35758 | CM4620 | CM-4620 | N...
  6. no_selection
    Wish List Compare
    GSK-7975A
    CAS: 1253186-56-9 Formula: C18H12F5N3O2 Molecular Weight: 397.30
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    Out of Stock Item #: G610729
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    Technical Identifiers
    IUPAC Name
    2,6-difluoro-N-[1-[[4-hydroxy-2-(trifluoromethyl)phenyl]methyl]pyrazol-3-yl]benzamide
    SMILES
    C1=CC(=C(C(=C1)F)C(=O)NC2=NN(C=C2)CC3=C(C=C(C=C3)O)C(F)(F)F)F
    InChIKey
    CPYTVBALBFSXSH-UHFFFAOYSA-N
    InChI
    1S/C18H12F5N3O2/c19-13-2-1-3-14(20)16(13)17(28)24-15-6-7-26(25-15)9-10-4-5-11(27)8-12(10)18(21,22)23/h1-8,27H,9H2,(H,24,25,28)
    Synonyms
    example 36 [US20120053150A1] | GSK7975A
  9. Pyr6 - Moligand™,≥99% CAS No(245747-08-4) by Aladdin Scientific
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    Pyr6
    CAS: 245747-08-4 EC Number: 808-615-3 PubChem CID: 10598093 Formula: C17H9F7N4O Molecular Weight: 418.27
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    Out of Stock Item #: P646980
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    Technical Identifiers
    IUPAC Name
    N-[4-[3,5-bis(trifluoromethyl)pyrazol-1-yl]phenyl]-3-fluoropyridine-4-carboxamide
    SMILES
    C1=CC(=CC=C1NC(=O)C2=C(C=NC=C2)F)N3C(=CC(=N3)C(F)(F)F)C(F)(F)F
    InChIKey
    XZIQSOZOLJJMFN-UHFFFAOYSA-N
    InChI
    1S/C17H9F7N4O/c18-12-8-25-6-5-11(12)15(29)26-9-1-3-10(4-2-9)28-14(17(22,23)24)7-13(27-28)16(19,20)21/h1-8H,(H,26,29)
    Synonyms
    AKOS030526749 | XZIQSOZOLJJMFN-UHFFFAOYSA-N | BDBM50450630 | PYR6 | n-[4-[3,5-bis(trifluoromethyl)-1h-pyrazol-1-yl]ph...
  10. GSK-5498A
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    GSK-5498A
    CAS: 1253186-49-0 PubChem CID: 46945384 Formula: C18H11F6N3O Molecular Weight: 399.29
    ≥98%
    Out of Stock Item #: G649231
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    Pricing & Pack Sizes
    Technical Identifiers
    IUPAC Name
    2,6-difluoro-N-[1-[[2-fluoro-6-(trifluoromethyl)phenyl]methyl]pyrazol-3-yl]benzamide
    SMILES
    C1=CC(=C(C(=C1)F)CN2C=CC(=N2)NC(=O)C3=C(C=CC=C3F)F)C(F)(F)F
    InChIKey
    AUBGZAJDHUHMAE-UHFFFAOYSA-N
    InChI
    1S/C18H11F6N3O/c19-12-4-1-3-11(18(22,23)24)10(12)9-27-8-7-15(26-27)25-17(28)16-13(20)5-2-6-14(16)21/h1-8H,9H2,(H,25,26,28)
  11. Synta66
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    Synta66
    CAS: 835904-51-3 PubChem CID: 11337104 Formula: C20H17FN2O3 Molecular Weight: 352.36
    ≥99%
    Out of Stock Item #: S649444
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    Pricing & Pack Sizes
    Technical Identifiers
    IUPAC Name
    N-[4-(2,5-dimethoxyphenyl)phenyl]-3-fluoropyridine-4-carboxamide
    SMILES
    COC1=CC(=C(C=C1)OC)C2=CC=C(C=C2)NC(=O)C3=C(C=NC=C3)F
    InChIKey
    GFEIWXNLDKUWIK-UHFFFAOYSA-N
    InChI
    1S/C20H17FN2O3/c1-25-15-7-8-19(26-2)17(11-15)13-3-5-14(6-4-13)23-20(24)16-9-10-22-12-18(16)21/h3-12H,1-2H3,(H,23,24)
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