Receptor tyrosine-protein kinase erbb-3 (ERBB3)

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  1. Canertinib dihydrochloride, Receptor protein-tyrosine kinase erbB-4 inhibitor
    CAS: 289499-45-2 EC Number: 663-691-3 PubChem CID: 156413 Formula: C24H25ClFN5O3·2HCl Molecular Weight: 558.86
    In Stock Item #: C169301
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    IUPAC Name
    N-[4-(3-chloro-4-fluoroanilino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]prop-2-enamide;dihydrochloride
    SMILES
    C=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4.Cl.Cl
    InChIKey
    JZZFDCXSFTVOJY-UHFFFAOYSA-N
    InChI
    1S/C24H25ClFN5O3.2ClH/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16;;/h2,4-5,12-15H,1,3,6-show more
    Synonyms
    Q27280663 | A817177 | CI 1033 | EN300-19659633 | Canertinib(dihydrochloride) | PD 183805 | AKOS015924656 | Canertinib...
  2. PF 6274484
    CAS: 1035638-91-5 PubChem CID: 74766099 Formula: C18H14ClFN4O2 Molecular Weight: 372.78
    In Stock Item #: P288199
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    IUPAC Name
    N-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]prop-2-enamide
    SMILES
    COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)NC(=O)C=C
    InChIKey
    TUYDDIWQXWTNSW-UHFFFAOYSA-N
    InChI
    1S/C18H14ClFN4O2/c1-3-17(25)24-15-7-11-14(8-16(15)26-2)21-9-22-18(11)23-10-4-5-13(20)12(19)6-10/h3-9H,1H2,2H3,(H,24,25)(H,21,22,23)
    Synonyms
    PF-6274484 | N-4-(3-Chloro-4-fluorophenyl)amino-7-methoxy-6-quinazolinyl-2-propenamide | N-[4-[(3-Chloro-4-fluorophen...
  3. AZD8931 (Sapitinib), Epidermal growth factor receptor erbB1 inhibitor
    CAS: 848942-61-0 EC Number: 642-427-0 Formula: C23H25ClFN5O3 Molecular Weight: 473.93
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: A129380
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    IUPAC Name
    2-[4-[4-(3-chloro-2-fluoroanilino)-7-methoxyquinazolin-6-yl]oxypiperidin-1-yl]-N-methylacetamide
    SMILES
    CNC(=O)CN1CCC(CC1)OC2=C(C=C3C(=C2)C(=NC=N3)NC4=C(C(=CC=C4)Cl)F)OC
    InChIKey
    DFJSJLGUIXFDJP-UHFFFAOYSA-N
    InChI
    1S/C23H25ClFN5O3/c1-26-21(31)12-30-8-6-14(7-9-30)33-20-10-15-18(11-19(20)32-2)27-13-28-23(15)29-17-5-3-4-16(24)22(17)25/h3-5,10-11,13-14H,6-9,12H2,1-2show more
    Synonyms
    4-AMINOmethylbenZAMIDINE dihydrochloride | BCP9000357 | GTPL7717 | AS-17066 | BCPP000365 | Sapitinib [INN] | s2192 | ...
  4. Osimertinib (AZD9291), Epidermal growth factor receptor erbB1 inhibitor
    CAS: 1421373-65-0 EC Number: 108-168-8 Formula: C28H33N7O2 Molecular Weight: 499.62
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    In Stock Item #: A302849
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    IUPAC Name
    N-[2-[2-(dimethylamino)ethyl-methylamino]-4-methoxy-5-[[4-(1-methylindol-3-yl)pyrimidin-2-yl]amino]phenyl]prop-2-enamide
    SMILES
    CN1C=C(C2=CC=CC=C21)C3=NC(=NC=C3)NC4=C(C=C(C(=C4)NC(=O)C=C)N(C)CCN(C)C)OC
    InChIKey
    DUYJMQONPNNFPI-UHFFFAOYSA-N
    InChI
    1S/C28H33N7O2/c1-7-27(36)30-22-16-23(26(37-6)17-25(22)34(4)15-14-33(2)3)32-28-29-13-12-21(31-28)20-18-35(5)24-11-9-8-10-19(20)24/h7-13,16-18H,1,14-15Hshow more
    Synonyms
    Mereletinib | AZD-9291
  5. Erlotinib, Inhibitor of epidermal growth factor receptor;Inhibitor of OATP2B1
    CAS: 183321-74-6 EC Number: 689-196-2 Formula: C22H23N3O4 Molecular Weight: 393.44
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: E126633
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    IUPAC Name
    N-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine
    SMILES
    COCCOC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC=CC(=C3)C#C)OCCOC
    InChIKey
    AAKJLRGGTJKAMG-UHFFFAOYSA-N
    InChI
    1S/C22H23N3O4/c1-4-16-6-5-7-17(12-16)25-22-18-13-20(28-10-8-26-2)21(29-11-9-27-3)14-19(18)23-15-24-22/h1,5-7,12-15H,8-11H2,2-3H3,(H,23,24,25)
    Synonyms
    R 1415 | Kinome_3317 | n-(3-ethynylphenyl)-6,7-bis(2-methoxyethoxy)-4-quinazolinamine monohydrochloride | Tox21_30121...
  6. CO-1686 (AVL-301), Epidermal growth factor receptor erbB1 inhibitor
    CAS: 1374640-70-6 EC Number: 811-332-8 Formula: C27H28F3N7O3 Molecular Weight: 555.55
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    In Stock Item #: C124905
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    IUPAC Name
    N-[3-[[2-[4-(4-acetylpiperazin-1-yl)-2-methoxyanilino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide
    SMILES
    CC(=O)N1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)NC4=CC(=CC=C4)NC(=O)C=C)C(F)(F)F)OC
    InChIKey
    HUFOZJXAKZVRNJ-UHFFFAOYSA-N
    InChI
    1S/C27H28F3N7O3/c1-4-24(39)32-18-6-5-7-19(14-18)33-25-21(27(28,29)30)16-31-26(35-25)34-22-9-8-20(15-23(22)40-3)37-12-10-36(11-13-37)17(2)38/h4-9,14-16show more
    Synonyms
    NSC779405 | NSC-779405 | s7284 | NCGC00386293-08 | SB16488 | HUFOZJXAKZVRNJ-UHFFFAOYSA-N | CO1686 | CO-1686 | DB11907...
  7. CO-1686 (AVL-301), Epidermal growth factor receptor erbB1 inhibitor
    CAS: 1374640-70-6 EC Number: 811-332-8 Formula: C27H28F3N7O3 Molecular Weight: 555.55
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    In Stock Item #: C421423
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    Technical Identifiers
    IUPAC Name
    N-[3-[[2-[4-(4-acetylpiperazin-1-yl)-2-methoxyanilino]-5-(trifluoromethyl)pyrimidin-4-yl]amino]phenyl]prop-2-enamide
    SMILES
    CC(=O)N1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=C(C(=N3)NC4=CC(=CC=C4)NC(=O)C=C)C(F)(F)F)OC
    InChIKey
    HUFOZJXAKZVRNJ-UHFFFAOYSA-N
    InChI
    1S/C27H28F3N7O3/c1-4-24(39)32-18-6-5-7-19(14-18)33-25-21(27(28,29)30)16-31-26(35-25)34-22-9-8-20(15-23(22)40-3)37-12-10-36(11-13-37)17(2)38/h4-9,14-16show more
    Synonyms
    NSC779405 | NSC-779405 | s7284 | NCGC00386293-08 | SB16488 | HUFOZJXAKZVRNJ-UHFFFAOYSA-N | CO1686 | CO-1686 | DB11907...
  8. Canertinib dihydrochloride, Receptor protein-tyrosine kinase erbB-4 inhibitor
    CAS: 289499-45-2 EC Number: 663-691-3 PubChem CID: 156413 Formula: C24H25ClFN5O3·2HCl Molecular Weight: 558.86
    10mM in DMSO
    In Stock Item #: C423017
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    Pricing & Pack Sizes
    Technical Identifiers
    IUPAC Name
    N-[4-(3-chloro-4-fluoroanilino)-7-(3-morpholin-4-ylpropoxy)quinazolin-6-yl]prop-2-enamide;dihydrochloride
    SMILES
    C=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OCCCN4CCOCC4.Cl.Cl
    InChIKey
    JZZFDCXSFTVOJY-UHFFFAOYSA-N
    InChI
    1S/C24H25ClFN5O3.2ClH/c1-2-23(32)30-21-13-17-20(14-22(21)34-9-3-6-31-7-10-33-11-8-31)27-15-28-24(17)29-16-4-5-19(26)18(25)12-16;;/h2,4-5,12-15H,1,3,6-show more
    Synonyms
    Q27280663 | A817177 | CI 1033 | EN300-19659633 | Canertinib(dihydrochloride) | PD 183805 | AKOS015924656 | Canertinib...
  9. Erlotinib (OSI-774), Inhibitor of epidermal growth factor receptor;Inhibitor of OATP2B1
    CAS: 183321-74-6 EC Number: 689-196-2 Formula: C22H23N3O4 Molecular Weight: 393.44
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    In Stock Item #: E408359
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    Pricing & Pack Sizes
    Technical Identifiers
    Synonyms
    CP358774, NSC 718781, Tarceva
  10. Osimertinib (AZD9291), Epidermal growth factor receptor erbB1 inhibitor
    CAS: 1421373-65-0 EC Number: 108-168-8 Formula: C28H33N7O2 Molecular Weight: 499.62
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    In Stock Item #: O408946
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    Technical Identifiers
    Synonyms
    Mereletinib | 2-​Propenamide, N-​[2-​[[2-​(dimethylamino)​ethyl]​methylamino]​-​4-​methoxy-​5-​[[4-​(1-​methyl-​1H-​i...
  11. Sapitinib (AZD8931), Epidermal growth factor receptor erbB1 inhibitor
    CAS: 848942-61-0 EC Number: 642-427-0 Formula: C23H25ClFN5O3 Molecular Weight: 473.93
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    In Stock Item #: S408729
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    Technical Identifiers
    Synonyms
    2-(4-(4-(3-chloro-2-fluorophenylamino)-7-methoxyquinazolin-6-yloxy)piperidin-1-yl)-N-methylacetamide
  12. TX1-85-1, erb-b2 receptor tyrosine kinase 3
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    Out of Stock Item #: T614591
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    Technical Identifiers
    IUPAC Name
    N-[5-[1-[4-(4-acetylpiperazin-1-yl)cyclohexyl]-4-aminopyrazolo[3,4-d]pyrimidin-3-yl]-2-phenoxyphenyl]prop-2-enamide
    SMILES
    C=CC(=O)Nc1cc(ccc1Oc1ccccc1)c1nn(c2c1c(N)ncn2)C1CCC(CC1)N1CCN(CC1)C(=O)C
    InChIKey
    FYICDSWKKFSYOM-UHFFFAOYSA-N
    InChI
    1S/C32H36N8O3/c1-3-28(42)36-26-19-22(9-14-27(26)43-25-7-5-4-6-8-25)30-29-31(33)34-20-35-32(29)40(37-30)24-12-10-23(11-13-24)39-17-15-38(16-18-39)21(2)show more
    Synonyms
    TX-85-1
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