Tyrosine-protein kinase txk (TXK)

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  1. BMS-986142
    CAS: 1643368-58-4 Formula: C32H30F2N4O4 Molecular Weight: 572.60
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    Out of Stock Item #: B413993
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    IUPAC Name
    (7S)-3-fluoro-4-[3-(8-fluoro-1-methyl-2,4-dioxoquinazolin-3-yl)-2-methylphenyl]-7-(2-hydroxypropan-2-yl)-6,7,8,9-tetrahydro-5H-carbazole-1-carboxamide
    SMILES
    CC1=C(C=CC=C1N2C(=O)C3=C(C(=CC=C3)F)N(C2=O)C)C4=C(C=C(C5=C4C6=C(N5)CC(CC6)C(C)(C)O)C(=O)N)F
    InChIKey
    ZRYMMWAJAFUANM-INIZCTEOSA-N
    InChI
    1S/C32H30F2N4O4/c1-15-17(7-6-10-24(15)38-30(40)19-8-5-9-21(33)28(19)37(4)31(38)41)25-22(34)14-20(29(35)39)27-26(25)18-12-11-16(32(2,3)42)13-23(18)36-2show more
    Synonyms
    (2S)-6-fluoro-5-[3-(8-fluoro-1-methyl-2,4-dioxo-1,4-dihydroquinazolin-3(2H)-yl)-2-methylphenyl]-2-(2-hydroxypropan-2-...
  2. Branebrutinib (BMS-986195), Inhibitor of Bruton tyrosine kinase
    CAS: 1912445-55-6 PubChem CID: 121293929 Formula: C20H23FN4O2 Molecular Weight: 370.42
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    Out of Stock Item #: B414208
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    IUPAC Name
    4-[(3S)-3-(but-2-ynoylamino)piperidin-1-yl]-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide
    SMILES
    CC#CC(=O)NC1CCCN(C1)C2=C(C=C(C3=C2C(=C(N3)C)C)C(=O)N)F
    InChIKey
    VJPPLCNBDLZIFG-ZDUSSCGKSA-N
    InChI
    1S/C20H23FN4O2/c1-4-6-16(26)24-13-7-5-8-25(10-13)19-15(21)9-14(20(22)27)18-17(19)11(2)12(3)23-18/h9,13,23H,5,7-8,10H2,1-3H3,(H2,22,27)(H,24,26)/t13-/mshow more
    Synonyms
    4-((3S)-3-(2-Butynoylamino)-1-piperidinyl)-5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide | 4-((3S)-3-(2-BUTYNOYLAMINO...
  3. Ritlecitinib (PF-06651600), TEC family kinase inhibitor
    CAS: 1792180-81-4 EC Number: 815-269-7 PubChem CID: 118115473 Formula: C15H19N5O Molecular Weight: 285.34
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    In Stock Item #: R422181
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    IUPAC Name
    1-[(2S,5R)-2-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)piperidin-1-yl]prop-2-en-1-one
    SMILES
    C=CC(N1[C@@H](C)CC[C@@H](NC2=C3C(NC=C3)=NC=N2)C1)=O
    InChIKey
    CBRJPFGIXUFMTM-WDEREUQCSA-N
    InChI
    1S/C15H19N5O/c1-3-13(21)20-8-11(5-4-10(20)2)19-15-12-6-7-16-14(12)17-9-18-15/h3,6-7,9-11H,1,4-5,8H2,2H3,(H2,16,17,18,19)/t10-,11+/m0/s1
    Synonyms
    DB14924 | Ritlecitinib? | RITLECITINIB [WHO-DD] | PF06651600;PF 06651600 | GTPL9559 | DS-13951 | HY-100754 | AC-35550...
  4. Ritlecitinib (PF-06651600), TEC family kinase inhibitor
    CAS: 1792180-81-4 EC Number: 815-269-7 PubChem CID: 118115473 Formula: C15H19N5O Molecular Weight: 285.34
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: R414045
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    IUPAC Name
    1-[(2S,5R)-2-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)piperidin-1-yl]prop-2-en-1-one
    SMILES
    C=CC(N1[C@@H](C)CC[C@@H](NC2=C3C(NC=C3)=NC=N2)C1)=O
    InChIKey
    CBRJPFGIXUFMTM-WDEREUQCSA-N
    InChI
    1S/C15H19N5O/c1-3-13(21)20-8-11(5-4-10(20)2)19-15-12-6-7-16-14(12)17-9-18-15/h3,6-7,9-11H,1,4-5,8H2,2H3,(H2,16,17,18,19)/t10-,11+/m0/s1
    Synonyms
    DB14924 | RITLECITINIB [WHO-DD] | PF06651600;PF 06651600 | GTPL9559 | DS-13951 | HY-100754 | AC-35550 | PF 06651600 |...
  5. 2-methyl-N-(2-{[3-(prop-2-enamido)phenyl]amino}pyrimidin-5-yl)-5-[3-(trifluoromethyl)benzamido]benzamide, Inhibitor of BLK proto-oncogene; Src family tyrosine kinase;Inhibitor of BMX non-receptor tyrosine kinase;Inhibitor of Bruton tyrosine kinase;Inhibitor of tec protein tyrosine kinase;Inhibitor of TXK tyrosine kinase
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    Out of Stock Item #: M609107
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    IUPAC Name
    2-methyl-N-(2-{[3-(prop-2-enamido)phenyl]amino}pyrimidin-5-yl)-5-[3-(trifluoromethyl)benzamido]benzamide
    SMILES
    C=CC(=O)Nc1cccc(c1)Nc1ncc(cn1)NC(=O)c1cc(ccc1C)NC(=O)c1cccc(c1)C(F)(F)F
    InChIKey
    BTWVWABAWDKQNJ-UHFFFAOYSA-N
    InChI
    1S/C29H23F3N6O3/c1-3-25(39)35-20-8-5-9-21(13-20)38-28-33-15-23(16-34-28)37-27(41)24-14-22(11-10-17(24)2)36-26(40)18-6-4-7-19(12-18)29(30,31)32/h3-16H,show more
    Synonyms
    Q27076563 | BDBM50020471 | SCHEMBL15998146 | 2-methyl-N-(2-{[3-(prop-2-enamido)phenyl]amino}pyrimidin-5-yl)-5-[3-(tri...
  6. 2-methyl-N-[2-({3-[2-(prop-2-enamido)acetamido]phenyl}amino)pyrimidin-5-yl]-5-[3-(trifluoromethyl)benzamido]benzamide, Inhibitor of BLK proto-oncogene; Src family tyrosine kinase;Inhibitor of BMX non-receptor tyrosine kinase;Inhibitor of Bruton tyrosine kinase;Inhibitor of epidermal growth factor receptor;Inhibitor of erb-b2 receptor tyrosine kinase 2;Inhibitor of erb-b2
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    Out of Stock Item #: M609151
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    IUPAC Name
    2-methyl-N-[2-({3-[2-(prop-2-enamido)acetamido]phenyl}amino)pyrimidin-5-yl]-5-[3-(trifluoromethyl)benzamido]benzamide
    SMILES
    C=CC(=O)NCC(=O)Nc1cccc(c1)Nc1ncc(cn1)NC(=O)c1cc(ccc1C)NC(=O)c1cccc(c1)C(F)(F)F
    InChIKey
    SMOPKEHQPPXRSH-UHFFFAOYSA-N
    InChI
    1S/C31H26F3N7O4/c1-3-26(42)35-17-27(43)38-21-8-5-9-22(13-21)41-30-36-15-24(16-37-30)40-29(45)25-14-23(11-10-18(25)2)39-28(44)19-6-4-7-20(12-19)31(32,3show more
    Synonyms
    compound 38
  7. atuzabrutinib, Inhibitor of Bruton tyrosine kinase
    CAS: 1581714-49-9 EC Number: 852-695-2 PubChem CID: 73438222 Formula: C30H30FN7O2 Molecular Weight: 539.60
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: A607809
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    IUPAC Name
    (E)-2-[(3R)-3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4,4-dimethylpent-2-enenitrile
    SMILES
    Nc1c2c(ncn1)n(nc2c1c(cc(cc1)Oc1ccccc1)F)[C@H]1CN(CCC1)C(=O)/C(=C/C(C)(C)C)/C#N
    InChIKey
    KZMQPYCXSAGLTB-ZWUNQBBJSA-N
    InChI
    1S/C30H30FN7O2/c1-30(2,3)15-19(16-32)29(39)37-13-7-8-20(17-37)38-28-25(27(33)34-18-35-28)26(36-38)23-12-11-22(14-24(23)31)40-21-9-5-4-6-10-21/h4-6,9-1show more
    Synonyms
    PRN473 | SAR444727
  8. tirabrutinib, Tyrosine-protein kinase BTK inhibitor
    CAS: 1351636-18-4 EC Number: 888-020-3 PubChem CID: 54755438 Formula: C25H22N6O3 Molecular Weight: 454.5
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    Out of Stock Item #: T614478
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    IUPAC Name
    6-amino-9-[(3R)-1-but-2-ynoylpyrrolidin-3-yl]-7-(4-phenoxyphenyl)purin-8-one
    SMILES
    CC#CC(=O)N1CCC(C1)N2C3=NC=NC(=C3N(C2=O)C4=CC=C(C=C4)OC5=CC=CC=C5)N
    InChIKey
    SEJLPXCPMNSRAM-GOSISDBHSA-N
    InChI
    1S/C25H22N6O3/c1-2-6-21(32)29-14-13-18(15-29)31-24-22(23(26)27-16-28-24)30(25(31)33)17-9-11-20(12-10-17)34-19-7-4-3-5-8-19/h3-5,7-12,16,18H,13-15H2,1Hshow more
    Synonyms
    DB15227 | Q27283239 | 6-Amino-9-((3R)-1-(2-butynoyl)-3-pyrrolidinyl)-7-(4-phenoxyphenyl)-7,9-dihydro-8H-purin-8-one |...
  9. 3-[[4-(5-hydroxy-2-methylanilino)pyrimidin-2-yl]amino]benzenesulfonamide, Inhibitor of LCK proto-oncogene; Src family tyrosine kinase;Inhibitor of LYN proto-oncogene; Src family tyrosine kinase;Inhibitor of spleen associated tyrosine kinase;Inhibitor of TXK tyrosine kinase
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    Out of Stock Item #: H608970
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    IUPAC Name
    3-[[4-(5-hydroxy-2-methylanilino)pyrimidin-2-yl]amino]benzenesulfonamide
    SMILES
    Oc1ccc(c(c1)Nc1ccnc(n1)Nc1cccc(c1)S(=O)(=O)N)C
    InChIKey
    LKLIRPMEYRVLFV-UHFFFAOYSA-N
    InChI
    1S/C17H17N5O3S/c1-11-5-6-13(23)10-15(11)21-16-7-8-19-17(22-16)20-12-3-2-4-14(9-12)26(18,24)25/h2-10,23H,1H3,(H2,18,24,25)(H2,19,20,21,22)
    Synonyms
    compound 23
  10. 3-[(2Z)-2-[5-(difluoromethyl)-1,2-dihydrothieno[3,2-c]pyrazol-3-ylidene]indol-6-yl]pentan-3-ol, Inhibitor of IL2 inducible T cell kinase;Inhibitor of LCK proto-oncogene; Src family tyrosine kinase;Inhibitor of spleen associated tyrosine kinase;Inhibitor of TXK tyrosine kinase
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools.
    Out of Stock Item #: Z609425
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    IUPAC Name
    3-[(2Z)-2-[5-(difluoromethyl)-1,2-dihydrothieno[3,2-c]pyrazol-3-ylidene]indol-6-yl]pentan-3-ol
    SMILES
    CCC(c1ccc2c(c1)[nH]c(c2)c1n[nH]c2c1sc(c2)C(F)F)(CC)O
    InChIKey
    CQZZZUNOWZUNNG-UHFFFAOYSA-N
    InChI
    1S/C19H19F2N3OS/c1-3-19(25,4-2)11-6-5-10-7-13(22-12(10)8-11)16-17-14(23-24-16)9-15(26-17)18(20)21/h5-9,18,22,25H,3-4H2,1-2H3,(H,23,24)
    Synonyms
    thienopyrazolylindole inhibitor 477 | compound 7
  11. Rilzabrutinib(PRN1008), Tyrosine-protein kinase BTK inhibitor
    CAS: 1575596-29-0 EC Number: 866-250-5 Formula: C36H40FN9O3 Molecular Weight: 665.76
    Solid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    In Stock Item #: R613193
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    IUPAC Name
    (E)-2-[(3R)-3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carbonyl]-4-methyl-4-[4-(oxetan-3-yl)piperazin-1-yl]pentshow more
    SMILES
    CC(C)(\C=C(/C#N)C(=O)N1CCC[C@H](C1)n1nc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)ncnc12)N1CCN(CC1)C1COC1
    InChIKey
    LCFFREMLXLZNHE-GBOLQPHISA-N
    InChI
    1S/C36H40FN9O3/c1-36(2,45-15-13-43(14-16-45)26-21-48-22-26)18-24(19-38)35(47)44-12-6-7-25(20-44)46-34-31(33(39)40-23-41-34)32(42-46)29-11-10-28(17-30(show more
    Synonyms
    BDBM143212 | PRN 1008 | UNII-5G1WE425BI | Q50825085 | UNII-NWN58M4F5T | WHO 10966 | (R,E)-2-(3-(4-amino-3-(2-fluoro-4...
  12. JAK3-IN-1
    CAS: 1805787-93-2 PubChem CID: 92042864 Formula: C26H30ClN7O2 Molecular Weight: 508.02
    Liquid Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    Out of Stock Item #: J654830
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