RIP-Kinase

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  1. GSK872
    CAS: 1346546-69-7 Summenformel: C19H17N3O2S2 Molekulargewicht: 383.48
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● Auf Lager — US-Lager, Versand in die EU* Artikel #: G276439
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    N-(6-propan-2-ylsulfonylquinolin-4-yl)-1,3-benzothiazol-5-amine
    SMILES
    CC(C)S(=O)(=O)C1=CC2=C(C=CN=C2C=C1)NC3=CC4=C(C=C3)SC=N4
    InChIKey
    ZCDBTQNFAPKACC-UHFFFAOYSA-N
    InChI
    1S/C19H17N3O2S2/c1-12(2)26(23,24)14-4-5-16-15(10-14)17(7-8-20-16)22-13-3-6-19-18(9-13)21-11-25-19/h3-12H,1-2H3,(H,20,22)
    Synonyme
    GSK′872 | N-(6-(Isopropylsulfonyl)quinolin-4-yl)benzo[d]thiazol-5-amine
  2. GSK 583, Inhibitor of receptor interacting serine/threonine kinase 2
    CAS: 1346547-00-9 Summenformel: C20H19FN4O2S Molekulargewicht: 398.45
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC)
    ● Auf Lager — US-Lager, Versand in die EU* Artikel #: G286537
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    6-tert-butylsulfonyl-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine
    SMILES
    CC(C)(C)S(=O)(=O)C1=CC2=C(C=CN=C2C=C1)NC3=NNC4=C3C=C(C=C4)F
    InChIKey
    XLOGLWKOHPIJLV-UHFFFAOYSA-N
    InChI
    1S/C20H19FN4O2S/c1-20(2,3)28(26,27)13-5-7-16-14(11-13)17(8-9-22-16)23-19-15-10-12(21)4-6-18(15)24-25-19/h4-11H,1-3H3,(H2,22,23,24,25)
    Synonyme
    GSK 583 | GSK-2616583A
  3. Necrostatin-1, Inhibitor of indoleamine 2;3-dioxygenase 1;Inhibitor of receptor interacting serine/threonine kinase 1
    CAS: 4311-88-0 Summenformel: C13H13N3OS Molekulargewicht: 259.33
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    ● Auf Lager — US-Lager, Versand in die EU* Artikel #: N125522
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    5-(1H-indol-3-ylmethyl)-3-methyl-2-sulfanylideneimidazolidin-4-one
    SMILES
    CN1C(=O)C(NC1=S)CC2=CNC3=CC=CC=C32
    InChIKey
    TXUWMXQFNYDOEZ-UHFFFAOYSA-N
    InChI
    1S/C13H13N3OS/c1-16-12(17)11(15-13(16)18)6-8-7-14-10-5-3-2-4-9(8)10/h2-5,7,11,14H,6H2,1H3,(H,15,18)
    Synonyme
    5-(1H-indol-3-ylmethyl)-3-methyl-2-sulfanyl-3,5-dihydro-4H-imidazol-4-one | 5-(1H-indol-3-ylmethyl)-3-methyl-2-thioxo...
  4. Necrostatin-5
    CAS: 337349-54-9 Summenformel: C19H17N3O2S2 Molekulargewicht: 383.49
    ● Auf Lager — US-Lager, Versand in die EU* Artikel #: N274792
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    2-[[3-(4-methoxyphenyl)-4-oxo-5,6,7,8-tetrahydro-[1]benzothiolo[2,3-d]pyrimidin-2-yl]sulfanyl]acetonitrile
    SMILES
    COC1=CC=C(C=C1)N2C(=O)C3=C(N=C2SCC#N)SC4=C3CCCC4
    InChIKey
    VGONMECBFMCKBS-UHFFFAOYSA-N
    InChI
    1S/C19H17N3O2S2/c1-24-13-8-6-12(7-9-13)22-18(23)16-14-4-2-3-5-15(14)26-17(16)21-19(22)25-11-10-20/h6-9H,2-5,11H2,1H3
    Synonyme
    STL304760 | SCHEMBL12682848 | Necrostatin-5, >=98% (HPLC), solid | AKOS000510375 | Oprea1_213608 | Oprea1_435788 | HM...
  5. Primidone, Sodium channel alpha subunit blocker
    CAS: 125-33-7 EG-Nummer: 204-737-0 Summenformel: C12H14N2O2 Molekulargewicht: 218.25
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%(HPLC)
    ● Auf Lager — US-Lager, Versand in die EU* Artikel #: P129217
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    5-ethyl-5-phenyl-1,3-diazinane-4,6-dione
    SMILES
    CCC1(C(=O)NCNC1=O)C2=CC=CC=C2
    InChIKey
    DQMZLTXERSFNPB-UHFFFAOYSA-N
    InChI
    1S/C12H14N2O2/c1-2-12(9-6-4-3-5-7-9)10(15)13-8-14-11(12)16/h3-7H,2,8H2,1H3,(H,13,15)(H,14,16)
    Synonyme
    5-Phenyl-5-ethyl-hexahydropyrimidine-4,6-dione | Primidone (Mysoline) | PRIMIDONE (USP-RS) | Pyrimidone ''Medi-pets''...
  6. 7-Cl-O-Nec1, Inhibitor of receptor interacting serine/threonine kinase 1
    CAS: 852391-15-2 Summenformel: C13H12ClN3O2 Molekulargewicht: 277.7
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ● Auf Lager — US-Lager, Versand in die EU* Artikel #: C275378
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    5-[(7-chloro-1H-indol-3-yl)methyl]-3-methylimidazolidine-2,4-dione
    SMILES
    CN1C(=O)C(NC1=O)CC2=CNC3=C2C=CC=C3Cl
    InChIKey
    WIKGAEMMNQTUGL-UHFFFAOYSA-N
    InChI
    1S/C13H12ClN3O2/c1-17-12(18)10(16-13(17)19)5-7-6-15-11-8(7)3-2-4-9(11)14/h2-4,6,10,15H,5H2,1H3,(H,16,19)
    Synonyme
    5-((7-Chloro-1H-indol-3-yl)methyl)-3-methylimidazolidine-2,4-dione | Necrostatin 2 racemate (Nec-1s) | Necrostatin-1 ...
  7. OD36, Inhibitor of receptor interacting serine/threonine kinase 2
    CAS: 1638644-62-8 Summenformel: C16H15ClN4O2 Molekulargewicht: 330.77
    Feststoff Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98%
    ◐ .Auf Bestellung · 8–12 Wochen Artikel #: O287326
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    4-chloro-7,10-dioxa-13,17,18,21-tetrazatetracyclo[12.5.2.12,6.017,20]docosa-1(20),2(22),3,5,14(21),15,18-heptaene
    SMILES
    C1COCCOC2=CC(=CC(=C2)C3=C4N=C(N1)C=CN4N=C3)Cl
    InChIKey
    KTSDBMVHAKWDRK-UHFFFAOYSA-N
    InChI
    1S/C16H15ClN4O2/c17-12-7-11-8-13(9-12)23-6-5-22-4-2-18-15-1-3-21-16(20-15)14(11)10-19-21/h1,3,7-10H,2,4-6H2,(H,18,20)
    Synonyme
    6-Chloro-10,11,14,17-tetrahydro-13H-1,16-etheno-4,8-metheno-1H-pyrazolo[3,4-g][1,14,4,6]dioxadiazacyclohexadecine hyd...
  8. Primidone-d5
    CAS: 73738-06-4 Summenformel: C12H9D5N2O2 Molekulargewicht: 223.28
    ● Auf Lager — US-Lager, Versand in die EU* Artikel #: P334356
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    5-(1,1,2,2,2-pentadeuterioethyl)-5-phenyl-1,3-diazinane-4,6-dione
    SMILES
    CCC1(C(=O)NCNC1=O)C2=CC=CC=C2
    InChIKey
    DQMZLTXERSFNPB-ZBJDZAJPSA-N
    InChI
    1S/C12H14N2O2/c1-2-12(9-6-4-3-5-7-9)10(15)13-8-14-11(12)16/h3-7H,2,8H2,1H3,(H,13,15)(H,14,16)/i1D3,2D2
    Synonyme
    5-(Ethyl-d5)dihydro-5-phenyl-4,6(1H,5H)-pyrimidinedione | AKOS030242911 | HY-B0339S | 5-(1,1,2,2,2-pentadeuterioethyl...
  9. GSK 583, Inhibitor of receptor interacting serine/threonine kinase 2
    CAS: 1346547-00-9 Summenformel: C20H19FN4O2S Molekulargewicht: 398.45
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● Auf Lager — US-Lager, Versand in die EU* Artikel #: G421308
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    6-tert-butylsulfonyl-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine
    SMILES
    CC(C)(C)S(=O)(=O)C1=CC2=C(C=CN=C2C=C1)NC3=NNC4=C3C=C(C=C4)F
    InChIKey
    XLOGLWKOHPIJLV-UHFFFAOYSA-N
    InChI
    1S/C20H19FN4O2S/c1-20(2,3)28(26,27)13-5-7-16-14(11-13)17(8-9-22-16)23-19-15-10-12(21)4-6-18(15)24-25-19/h4-11H,1-3H3,(H2,22,23,24,25)
    Synonyme
    6-[(1,1-Dimethylethyl)sulfonyl]-N-(5-fluoro-1H-indazol-3-yl)-4-quinolinamine
  10. GSK'547, Inhibitor of receptor interacting serine/threonine kinase 1
    CAS: 2226735-55-1 Summenformel: C20H18F2N6O Molekulargewicht: 396.39
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● Auf Lager — US-Lager, Versand in die EU* Artikel #: G422673
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    6-[4-[(3S)-3-(3,5-difluorophenyl)-3,4-dihydropyrazole-2-carbonyl]piperidin-1-yl]pyrimidine-4-carbonitrile
    SMILES
    C1CN(CCC1C(=O)N2C(CC=N2)C3=CC(=CC(=C3)F)F)C4=NC=NC(=C4)C#N
    InChIKey
    SJVGFKBLUYAEOK-SFHVURJKSA-N
    InChI
    1S/C20H18F2N6O/c21-15-7-14(8-16(22)9-15)18-1-4-26-28(18)20(29)13-2-5-27(6-3-13)19-10-17(11-23)24-12-25-19/h4,7-10,12-13,18H,1-3,5-6H2/t18-/m0/s1
    Synonyme
    4-​Pyrimidinecarbonitri​le,6-​[4-​[[(5S)​-​5-​(3,​5-​difluorophenyl)​-​4,​5-​dihydro-​1H-​pyrazol-​1-​yl]​carbonyl]​-�...
  11. GSK547, Inhibitor of receptor interacting serine/threonine kinase 1
    CAS: 2226735-55-1 Summenformel: C20H18F2N6O Molekulargewicht: 396.39
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥99%
    ● Auf Lager — US-Lager, Versand in die EU* Artikel #: G414181
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    6-[4-[(3S)-3-(3,5-difluorophenyl)-3,4-dihydropyrazole-2-carbonyl]piperidin-1-yl]pyrimidine-4-carbonitrile
    SMILES
    C1CN(CCC1C(=O)N2C(CC=N2)C3=CC(=CC(=C3)F)F)C4=NC=NC(=C4)C#N
    InChIKey
    SJVGFKBLUYAEOK-SFHVURJKSA-N
    InChI
    1S/C20H18F2N6O/c21-15-7-14(8-16(22)9-15)18-1-4-26-28(18)20(29)13-2-5-27(6-3-13)19-10-17(11-23)24-12-25-19/h4,7-10,12-13,18H,1-3,5-6H2/t18-/m0/s1
    Synonyme
    4-​Pyrimidinecarbonitri​le,6-​[4-​[[(5S)​-​5-​(3,​5-​difluorophenyl)​-​4,​5-​dihydro-​1H-​pyrazol-​1-​yl]​carbonyl]​-�...
  12. GSK'963, Inhibitor of receptor interacting serine/threonine kinase 1
    CAS: 2049868-46-2 Summenformel: C14H18N2O Molekulargewicht: 230.31
    Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. 10mM in DMSO
    ● Auf Lager — US-Lager, Versand in die EU* Artikel #: G422489
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    2,2-dimethyl-1-[(3S)-3-phenyl-3,4-dihydropyrazol-2-yl]propan-1-one
    SMILES
    CC(C)(C)C(=O)N1C(CC=N1)C2=CC=CC=C2
    InChIKey
    NJQVSLWJBLPTMD-LBPRGKRZSA-N
    InChI
    1S/C14H18N2O/c1-14(2,3)13(17)16-12(9-10-15-16)11-7-5-4-6-8-11/h4-8,10,12H,9H2,1-3H3/t12-/m0/s1
    Synonyme
    1-​Propanone,1-​[(5S)​-​4,​5-​dihydro-​5-​phenyl-​1H-​pyrazol-​1-​yl]​-​2,​2-​dimethyl-
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Häufig gestellte Fragen

Which compounds are listed for RIP kinase?
Compounds associated with RIP kinase are grouped here under the Apoptosis classification, with mechanism, structure, and reported potency shown per entry. Use it as a starting shortlist rather than a final selection.
How does RIP kinase sit within Apoptosis?
RIP kinase is one target listing within the Apoptosis classification. Compounds here may also appear under related targets, so check the selectivity data rather than assuming the annotation is exclusive.
What data should I check before ordering a compound from RIP kinase?
For compounds listed under RIP kinase, check purity — typically 98% or better by HPLC — the reported potency and the assay it was measured in, solubility and recommended stock solvent, and storage and stability. Batch-specific values are given on the Certificate of Analysis. All products are supplied for professional research and development use only, and are not for use in humans, animals, diagnostics, or therapy.
How do I find related targets or backup compounds for RIP kinase?
Browse the parent Apoptosis listing to reach targets neighbouring RIP kinase, and use the structure search to find analogs of a compound that worked. Unlisted compounds and bulk quantities: [email protected]. We supply verified businesses, research institutions, universities, and government agencies.

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