m-PEG2-azide - ≥95% , CAS No.215181-61-6

CAS: 215181-61-6 Cat. No.: M412720 Molecular Weight: 145.16 EC Number: 111-056-1

GRADE & PURITY ≥95%

Synonyms

BT-0134 | m-PEG-azide, MW 30,000 | 1-azido-2-(2-methoxyethoxy)ethane | 1-Azido-2-(2-methoxy-ethoxy)-ethane | BP-20988 | BP-23444 | DTXSID201212327 | BP-28678 | HY-130578 | Methoxypolyethylene glycol azide, (mPEG), M.W. 550 | OXDZFVNIVMSPEG-UHFFFAOYSA-N |

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Application

227,228,229

Overview

m-PEG2-azide is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. m-PEG2-azide is a click chemistry reagent, itcontains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups. 

Application：

Applicated in medical research, drug-release, nanotechnology and new materials research, cell culture. In the study of ligand, polypeptide synthesis support, a graft polymer compounds, new materials, and polyethylene glycol-modified functional coatings and other aspects of the active compound.

Specifications

Synonyms

BT-0134 | m-PEG-azide, MW 30, 000 | 1-azido-2-(2-methoxyethoxy)ethane | 1-Azido-2-(2-methoxy-ethoxy)-ethane | BP-20988 | BP-23444 | DTXSID201212327 | BP-28678 | HY-130578 | Methoxypolyethylene glycol azide, (mPEG), M.W. 550 | OXDZFVNIVMSPEG-UHFFFAOYSA-N |

Specifications & Purity

≥95%

Biochemical and Physiological Mechanisms

m-PEG2-azide is a PEG-based PROTAC linker that is applicable to the synthesis of PROTACs.

Storage

Protected from light, Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥95%

Names and Identifiers

• Canonical Smiles: COCCOCCN=[N+]=[N-]
• IUPAC Name: 1-azido-2-(2-methoxyethoxy)ethane
• InChIKey: OXDZFVNIVMSPEG-UHFFFAOYSA-N
• INCHI: 1S/C5H11N3O2/c1-9-4-5-10-3-2-7-8-6/h2-5H2,1H3
• Isomeric SMILES: COCCOCCN=[N+]=[N-]
• Molecular Weight: 145.16
• Reaxy-Rn: 6918271
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=6918271&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic 1,3-dipolar compounds
    • Class Allyl-type 1,3-dipolar organic compounds
      • Subclass Azo imides

• Kingdom: Organic compounds
• Superclass: Organic 1,3-dipolar compounds
• Class: Allyl-type 1,3-dipolar organic compounds
• Subclass: Azo imides
• Intermediate Tree Nodes: Not available
• Direct Parent: Azo imides
• Alternative Parents: Azo compounds Dialkyl ethers Organic salts Hydrocarbon derivatives Organic cations
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Azo imide - Azo compound - Ether - Dialkyl ether - Organic nitrogen compound - Organic oxygen compound - Hydrocarbon derivative - Organic salt - Organooxygen compound - Organonitrogen compound - Organic cation - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as azo imides. These are n-Imides of azo compounds, analogous to azoxy compounds, having a delocalized structure.
• External Descriptors: Not available

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: Solubility (25°C) In vitro
• Sensitivity: Light sensitive
• Molecular Weight: 145.160 g/mol
• XLogP3: 0.800
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 145.085 Da
• Monoisotopic Mass: 145.085 Da
• Topological Polar Surface Area: 32.800 Ų
• Heavy Atom Count: 10
• Formal Charge: 0
• Complexity: 111.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Qiuxia Wu, Xinran Sun, Zhenming Yang, Pengfei Shi, Huacheng Zhang, Jie Han.  (2023)  Synthesis, Optical Properties and Cellular Toxicity of Water-Soluble near Infrared-II Fluorescent Assemblies Based on Pillar[5]arene.  Polymers,  15  (18): (3853).  [PMID:37765707] [10.3390/polym15183853]