MK-571 sodium - Moligand™, 10 mM in Water , CAS No.115103-85-0

CAS: 115103-85-0 Cat. No.: M1498964 Molecular Weight: 537.07

GRADE & PURITY Moligand™, 10 mM in Water

Storage

Desiccated,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

MK-571 (L-660711) sodium is an orally active, potent and selective competitive leukotriene D 4 (LTD 4 ) receptor antagonist, with K i values of 0.22 and 2.1 nM in guinea pig and human lung membranes, respectively. MK-571 sodium is also a inhibitor of multidrug resistance-associated protein MRP4 (ABCC4) and ABCC1 (MRP1) . MK-571 sodium inhibits constitutive and antigen-stimulated S1P (sphingosine-1-phosphate) release.

Specifications

Specifications & Purity

Moligand™, 10 mM in Water

Storage

Desiccated, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

ANTAGONIST

Product Properties

• pKa: pKₐ: 4.27, pKₐ: 2.18
• Ki Data: LTD4 binding to human lung membranes: Ki= 0.22 nM (human); LTD4 binding to guinea pig lung membranes: Ki= 2.1 nM (guinea pig); Cysteinyl leukotriene receptor 2: Ki= 0.2 nM (human); Cysteinyl leukotriene receptor 1: Ki= 0.2 nM (human)

Names and Identifiers

• Isomeric SMILES: CN(C)C(=O)CCSC(C1=CC=CC(=C1)/C=C/C2=NC3=C(C=CC(=C3)Cl)C=C2)SCCC(=O)[O-].[Na+]
• Molecular Weight: 537.07
• Reaxy-Rn: 28775434
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=28775434&ln=

References

1. Min Zhang, Ying Peng, Mengyue Wang, Beibei Gao, Lijuan Zhao, Xiaobo Li.  (2018)  The influence of compatibility of Si-Ni decoction with metabolism in intestinal bacteria on transports of toxic diterpenoid alkaloids from processed aconite root across Caco-2 monolayers.  JOURNAL OF ETHNOPHARMACOLOGY,      [PMID:30223050] [10.1016/j.jep.2018.09.022]