ML 179 - ≥98 atom% D,≥98% , CAS No.1883548-87-5

CAS: 1883548-87-5 Cat. No.: M288627 Molecular Weight: 422.44 PubChem CID: 75089674

GRADE & PURITY ≥98 atom% D,≥98%

Synonyms

2,5-Furandione-3,4-d2 | 3-Cyclohexyl-6-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-1H-pyrimidine-2,4-dione

Storage

Protected from light,Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

Product Describtion:

ML179 (SR-1309) is a inverse LRH1 (Liver receptor homologue-1) agonist with IC50 of 320 nM. ML179 shows anti-proliferation activity in MDA-MB-231 cells. ML179 has the potential for the research of ER-negative breast cancer .

Specifications

Synonyms

2, 5-Furandione-3, 4-d2 | 3-Cyclohexyl-6-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-1H-pyrimidine-2, 4-dione

Specifications & Purity

≥98 atom% D, ≥98%

Biochemical and Physiological Mechanisms

Selective liver receptor homolog 1 (LRH1, NR5A2) inverse agonist (IC50= 320 nM and maximum efficacy of 64% repression). Exhibits >31-fold selectivity over SF1.

Storage

Protected from light, Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥98 atom% D, ≥98%

Names and Identifiers

• Pubchem Sid: 488202353
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488202353
• Canonical Smiles: C1CCC(CC1)N2C(=O)CC(NC2=O)N3CCN(CC3)C4=CC=CC(=C4)C(F)(F)F
• IUPAC Name: 3-cyclohexyl-6-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-1,3-diazinane-2,4-dione
• InChIKey: KTWKLBPBUXCXRG-UHFFFAOYSA-N
• INCHI: 1S/C21H27F3N4O2/c22-21(23,24)15-5-4-8-17(13-15)26-9-11-27(12-10-26)18-14-19(29)28(20(30)25-18)16-6-2-1-3-7-16/h4-5,8,13,16,18H,1-3,6-7,9-12,14H2,(H,25,30)
• Isomeric SMILES: C1CCC(CC1)N2C(=O)CC(NC2=O)N3CCN(CC3)C4=CC=CC(=C4)C(F)(F)F
• PubChem CID: 75089674
• Molecular Weight: 422.44

Chemical and Physical Properties

• Solubility: Solvent:DMSO, Max Conc. mg/mL: 21.12, Max Conc. mM: 50
• Sensitivity: Moisture sensitive； Light sensitive