≥98% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
ML264 ML264 (CID-51003603), a selectively inhibitor of kruppel-like factor 5 (KLF5) ,potently Inhibits Growth of Colorectal Cancer.
Targets
KLF5 (Cell-based assay for proliferation of DLD-1 cells) 29 nM
In vitro
ML264 potently halts DLD-1 viability (IC50 = 29 nM) with high maximal effect (>90%). DLD-1 cells are human colorectal adenocarcinoma cells. ML264 has significant effects at submicromolar doses on other cell types as well, including HCT116 (human colorectal carcinoma), HT29 (human colorectal adenocarcinoma), and SW620 (human colorectal adenocarcinoma). The IEC-6 anti-target (a nontransformed rat intestinal epithelial cell line) is largely unaffected, with inhibition below 50% at the highest dose.This compound potently inhibits proliferation of CRC cells in vitro through modifications of the cell cycle profile.
In vivo
In an established xenograft mouse model of colon cancer, ML264 efficiently inhibits growth of the tumor within five days of treatment. this effect is caused by a significant reduction in proliferation and that ML264 potently inhibits the expression of KLF5 and EGR1, a transcriptional activator of KLF5.
Cell Research(from reference)
Cell lines：DLD-1 and HCT116 colorectal cancer cell lines
Concentrations：10μM
Incubation Time：24, 48, 72h
| Pubchem Sid | 504771001 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504771001 |
| Canonical Smiles | CN(C1CCS(=O)(=O)CC1)C(=O)CNC(=O)C=CC2=CC(=CC=C2)Cl |
| IUPAC Name | (E)-3-(3-chlorophenyl)-N-[2-[(1,1-dioxothian-4-yl)-methylamino]-2-oxoethyl]prop-2-enamide |
| InChIKey | AJCDZIDKYKCOMZ-AATRIKPKSA-N |
| INCHI | 1S/C17H21ClN2O4S/c1-20(15-7-9-25(23,24)10-8-15)17(22)12-19-16(21)6-5-13-3-2-4-14(18)11-13/h2-6,11,15H,7-10,12H2,1H3,(H,19,21)/b6-5+ |
| Isomeric SMILES | CN(C1CCS(=O)(=O)CC1)C(=O)CNC(=O)/C=C/C2=CC(=CC=C2)Cl |
| Molecular Weight | 384.88 |
| Reaxy-Rn | 33425728 |
| Reaxys-RN_link_address | https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=33425728&ln= |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →Taxonomy Tree
| Kingdom | Organic compounds |
|---|---|
| Superclass | Organic acids and derivatives |
| Class | Carboxylic acids and derivatives |
| Subclass | Amino acids, peptides, and analogues |
| Intermediate Tree Nodes | Amino acids and derivatives - Alpha amino acids and derivatives |
| Direct Parent | N-acyl-alpha amino acids and derivatives |
| Alternative Parents | Cinnamic acid amides Alpha amino acid amides Styrenes Chlorobenzenes Thianes Aryl chlorides Tertiary carboxylic acid amides Sulfones Tertiary amines Secondary carboxylic acid amides Organochlorides Organic oxides Hydrocarbon derivatives Carbonyl compounds |
| Molecular Framework | Aromatic heteromonocyclic compounds |
| Substituents | N-acyl-alpha amino acid or derivatives - Alpha-amino acid amide - Cinnamic acid amide - Cinnamic acid or derivatives - Styrene - Chlorobenzene - Halobenzene - Aryl chloride - Aryl halide - Monocyclic benzene moiety - Benzenoid - Thiane - Tertiary carboxylic acid amide - Sulfone - Carboxamide group - Tertiary amine - Secondary carboxylic acid amide - Organoheterocyclic compound - Organooxygen compound - Amine - Organic nitrogen compound - Carbonyl group - Hydrocarbon derivative - Organic oxide - Organic oxygen compound - Organonitrogen compound - Organohalogen compound - Organochloride - Aromatic heteromonocyclic compound |
| Description | This compound belongs to the class of organic compounds known as n-acyl-alpha amino acids and derivatives. These are compounds containing an alpha amino acid (or a derivative thereof) which bears an acyl group at its terminal nitrogen atom. |
| External Descriptors | Not available |
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Find and download the COA for your product by matching the lot number on the packaging.
| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 G2321423 | Certificate of Analysis | May 09, 2026 | M413940 |
| G2321433 | Certificate of Analysis | May 09, 2026 | M413940 |
| G2321529 | Certificate of Analysis | May 09, 2026 | M413940 |
| G2321535 | Certificate of Analysis | May 09, 2026 | M413940 |
| G2321538 | Certificate of Analysis | May 09, 2026 | M413940 |
| G2321542 | Certificate of Analysis | May 09, 2026 | M413940 |
| G2321544 | Certificate of Analysis | May 09, 2026 | M413940 |
| G2321550 | Certificate of Analysis | May 09, 2026 | M413940 |
| G2321552 | Certificate of Analysis | May 09, 2026 | M413940 |
| G2321553 | Certificate of Analysis | May 09, 2026 | M413940 |
| Solubility | Solubility (25°C) In vitro DMSO: 76 mg/mL (197.46 mM); Water: Insoluble; Ethanol: Insoluble; |
|---|---|
| Molecular Weight | 384.900 g/mol |
| XLogP3 | 1.700 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 5 |
| Exact Mass | 384.091 Da |
| Monoisotopic Mass | 384.091 Da |
| Topological Polar Surface Area | 91.900 Ų |
| Heavy Atom Count | 25 |
| Formal Charge | 0 |
| Complexity | 601.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 0 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 1 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 1 |
| Covalently-Bonded Unit Count | 1 |
