Name: MP7 - ≥99% , CAS No.1001409-50-2
Brand: Aladdin Scientific
SKU: M651716
Availability: InStock

MP7 - ≥99% , CAS No.1001409-50-2

CAS: 1001409-50-2 Cat. No.: M651716 Molecular Weight: 516.50 PubChem CID: 49766501

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MP7 - ≥99% CAS No(1001409-50-2) by Aladdin Scientific

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AVAILABLE TO ORDER

GRADE & PURITY ≥99%

Synonyms

DTXSID90678515 | 1-(3,4-Difluorobenzyl)-2-Oxo-N-{(1r)-2-[(2-Oxo-2,3-Dihydro-1h-Benzimidazol-5-Yl)oxy]-1-Phenylethyl}-1,2-Dihydropyridine-3-Carboxamide | BRD-K09186807-001-01-6 | CHEBI:91373 | HY-14440 | PDK1 inhibitor | BDBM50361645 | NCGC00346947-02 | SC

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Size

Status

Price

Qty

5mg

M651716-5mg

8-12 wks(?)

$89.90

1mg

M651716-1mg

8-12 wks(?)

$39.90

10mg

M651716-10mg

8-12 wks(?)

$149.90

50mg

M651716-50mg

8-12 wks(?)

$599.90

100mg

M651716-100mg

8-12 wks(?)

$999.90

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Overview Specifications Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solution Calculators Reviews

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Why this grade

≥99% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

MP7 (PDK1 inhibitor) is a phosphoinositide-dependent kinase-1 ( PDK1 ) inhibitor.

In Vitro

Cell counting of U87MG-derived glioma stem cells (GSCs) confirms that Alisertib and, to a minor extent, MP7 (PDK1 inhibitor) are able to decrease the number of viable cells. When combined together, GSC viability is further reduced with respect to single-treated cells. As observed in U87MG cells, when used at the highest concentrations (i.e., 1.5 μM Alisertib and 2.5 μM MP7), a significant enhancement in the number of dead cells is evidenced. Following 72 h treatment, MP7 alone does not show a significant inhibition of glioblastoma multiforme (GBM) proliferation. MP7 has been shown to have only minimal effects on monolayer cell growth in several cancer cell lines, with IC 50 values in the micromolar range. MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Form:Solid

IC50& Target:PDK1

Specifications

Synonyms

DTXSID90678515 | 1-(3, 4-Difluorobenzyl)-2-Oxo-N-{(1r)-2-[(2-Oxo-2, 3-Dihydro-1h-Benzimidazol-5-Yl)oxy]-1-Phenylethyl}-1, 2-Dihydropyridine-3-Carboxamide | BRD-K09186807-001-01-6 | CHEBI:91373 | HY-14440 | PDK1 inhibitor | BDBM50361645 | NCGC00346947-02 | SC

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

MP7 (PDK1 inhibitor) is a phosphoinositide-dependent kinase-1 ( PDK1 ) inhibitor.

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥99%

Names and Identifiers

Canonical Smiles	C1=CC=C(C=C1)C(COC2=CC3=C(C=C2)NC(=O)N3)NC(=O)C4=CC=CN(C4=O)CC5=CC(=C(C=C5)F)F
IUPAC Name	1-[(3,4-difluorophenyl)methyl]-2-oxo-N-[(1R)-2-[(2-oxo-1,3-dihydrobenzimidazol-5-yl)oxy]-1-phenylethyl]pyridine-3-carboxamide
InChIKey	GCWCGSPBENFEPE-VWLOTQADSA-N
INCHI	1S/C28H22F2N4O4/c29-21-10-8-17(13-22(21)30)15-34-12-4-7-20(27(34)36)26(35)31-25(18-5-2-1-3-6-18)16-38-19-9-11-23-24(14-19)33-28(37)32-23/h1-14,25H,15-16H2,(H,31,35)(H2,32,33,37)/t25-/m0/s1
Isomeric SMILES	C1=CC=C(C=C1)[C@H](COC2=CC3=C(C=C2)NC(=O)N3)NC(=O)C4=CC=CN(C4=O)CC5=CC(=C(C=C5)F)F
Alternate CAS	1001409-50-2
PubChem CID	49766501
Molecular Weight	516.50

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Class Benzimidazoles

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Class	Benzimidazoles
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Benzimidazoles
Alternative Parents	Nicotinamides Alkyl aryl ethers Dihydropyridines Fluorobenzenes Pyridinones Aryl fluorides Vinylogous amides Imidazoles Heteroaromatic compounds Lactams Secondary carboxylic acid amides Ureas Azacyclic compounds Organonitrogen compounds Organofluorides Organic oxides Hydrocarbon derivatives Organopnictogen compounds
Molecular Framework	Aromatic heteropolycyclic compounds
Substituents	Nicotinamide - Benzimidazole - Pyridine carboxylic acid or derivatives - Alkyl aryl ether - Halobenzene - Fluorobenzene - Dihydropyridine - Pyridinone - Aryl fluoride - Aryl halide - Hydropyridine - Monocyclic benzene moiety - Benzenoid - Pyridine - Azole - Imidazole - Heteroaromatic compound - Vinylogous amide - Lactam - Urea - Secondary carboxylic acid amide - Carboxamide group - Azacycle - Carboxylic acid derivative - Ether - Organonitrogen compound - Organooxygen compound - Organic nitrogen compound - Hydrocarbon derivative - Organic oxide - Organopnictogen compound - Organic oxygen compound - Organofluoride - Organohalogen compound - Aromatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as benzimidazoles. These are organic compounds containing a benzene ring fused to an imidazole ring (five member ring containing a nitrogen atom, 4 carbon atoms, and two double bonds).
External Descriptors	Not available
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D Structure

Associated Targets(Human)

PDPK1 Tchem 3-phosphoinositide-dependent protein kinase 1 (1 Activities)

Discover Target: PDPK1

Activity Type	Activity Value -log(M)	Mechanism of Action	Activity Reference	Publications (PubMed IDs)

PDPK1 Tchem 3-phosphoinositide dependent protein kinase-1 (3758 Activities)

Discover Target: PDPK1

Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

A-427 (643 Activities)

Solubility	DMSO : ≥ 100 mg/mL (193.61 mM)
Molecular Weight	516.500 g/mol
XLogP3	4.000
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	8
Exact Mass	516.161 Da
Monoisotopic Mass	516.161 Da
Topological Polar Surface Area	99.800 Å²
Heavy Atom Count	38
Formal Charge	0
Complexity	953.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

MP7 - ≥99% , CAS No.1001409-50-2

Why this grade

Storage & shipping

Quality documents

Literature proof

Overview

Specifications

Documentation

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

Customer Reviews

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