N,N-Dimethylformamide Dimethyl Acetal（DMF-DMA） - ≥97% , CAS No.4637-24-5

CAS: 4637-24-5 Cat. No.: D106288 Molecular Weight: 119.16 Beilstein Registry Number: 506020 EC Number: 225-063-3

GRADE & PURITY ≥97%

Synonyms

DMF-DMA | dimetylformamide dimethyl acetal | DMF dimethylacetal | n,n-dimethylformamid-dimethylacetal | N,N-Dimethylformamidedimethylacetal | n,n-dimethylformamide-dimethylacetal | 1,1-Dimethoxy-N,N-dimethylmethylamine | 1,1-Dimethoxy-N,N-dimethyl-methyla

Storage

Room temperature,Argon charged

Shipped In

Normal

Overview

N,N-Dimethylformamide dimethyl acetal is a reagent for n-dimethylaminomethylene and methyl esters. It is used to catalyze the coupling of epoxides with carbon dioxide under solvent free conditions leading to cyclic carbonates.
A reagent for n-dimethylaminomethylene and methyl esters;It may be used in methylation of heterocyclic compounds which contains SH, NH, OH groups such as benzimidazole, naphth[2,3-c]imidazole, imidazo[4,5-c]-pyridine, purine, pyridine, pyrimidine, pyridazine and s-triazolo[4,3-b]pyridazine. It was used as derivatizing agent in a study to determine cocaine and benzoyl ecgonine in urine using GC with on-column alkylation. Suitable for the derivatization of primary sulfonamides and trifluoroacetic acid. Used in the preparation of formamidine derivatives, which are synthetic intermediates. Used to catalyze the coupling of epoxides with carbon dioxide under solvent free conditions leading to cyclic carbonates.

Specifications

Synonyms

DMF-DMA | dimetylformamide dimethyl acetal | DMF dimethylacetal | n, n-dimethylformamid-dimethylacetal | N, N-Dimethylformamidedimethylacetal | n, n-dimethylformamide-dimethylacetal | 1, 1-Dimethoxy-N, N-dimethylmethylamine | 1, 1-Dimethoxy-N, N-dimethyl-methyla

Specifications & Purity

≥97%

Storage

Room temperature, Argon charged

Shipped In

Normal

Purity

≥97%

Names and Identifiers

• Pubchem Sid: 488185569
• Pubchem Sid Url: https://pubchem.ncbi.nlm.nih.gov/substance/488185569
• Canonical Smiles: CN(C)C(OC)OC
• IUPAC Name: 1,1-dimethoxy-N,N-dimethylmethanamine
• InChIKey: ZSXGLVDWWRXATF-UHFFFAOYSA-N
• INCHI: 1S/C5H13NO2/c1-6(2)5(7-3)8-4/h5H,1-4H3
• Isomeric SMILES: CN(C)C(OC)OC
• WGK Germany: 2
• UN Number: 1993
• Molecular Weight: 119.16
• Beilstein: 506020
• Reaxy-Rn: 506020
• Reaxys-RN_link_address: https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=506020&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Organic acids and derivatives
    • Class Orthocarboxylic acid derivatives
      • Subclass Carboxylic acid amide acetals

• Kingdom: Organic compounds
• Superclass: Organic acids and derivatives
• Class: Orthocarboxylic acid derivatives
• Subclass: Carboxylic acid amide acetals
• Intermediate Tree Nodes: Not available
• Direct Parent: Carboxylic acid amide acetals
• Alternative Parents: Organopnictogen compounds Organooxygen compounds Organonitrogen compounds Hydrocarbon derivatives
• Molecular Framework: Aliphatic acyclic compounds
• Substituents: Amide acetal - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Aliphatic acyclic compound
• Description: This compound belongs to the class of organic compounds known as carboxylic acid amide acetals. These are carboxylic acid derivatives two hydroxyl groups attached to a carbon atom, which in turn is linked to a nitrogen atom(substituted or not).
• External Descriptors: tertiary amino compound - acetal

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

Chemical and Physical Properties

• Solubility: Miscible with most organic solvents.
• Sensitivity: Moisture sensitive.
• Refractive Index: 1.3972
• Flash Point(°F): 42.8 °F
• Flash Point(°C): 7℃
• Boil Point(°C): 104-108°C
• Melt Point(°C): -85°C
• Molecular Weight: 119.160 g/mol
• XLogP3: 0.200
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 119.095 Da
• Monoisotopic Mass: 119.095 Da
• Topological Polar Surface Area: 21.700 Ų
• Heavy Atom Count: 8
• Formal Charge: 0
• Complexity: 52.400
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 0
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1

References

1. Hailin Zhang, Tingting Zhou, Xiangyu Li, Wenbiao Xu, Junyou Shi.  (2025)  Efficient green Pre-Treatment of coniferous biomass using Alkali-Assisted deep eutectic solvents for tall oil production and lignin component separation.  SEPARATION AND PURIFICATION TECHNOLOGY,      [PMID:] [10.1016/j.seppur.2025.131474]

2. Pengtao Yuan, Xi Jiang, Xintong Ni, Xusheng Shao, Xuhong Qian, Qing Yang.  (2025)  Discovery of conformation constrained tetracyclic compounds as potent chitinase OfChi-h inhibitors with a novel binding mode.  JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY,      [PMID:40619956] [10.1080/14756366.2025.2528056]

3. Lingyu Chen, Yunhong Liu, Xinyan Peng, Yuelan Wei, Ke Shao.  (2025)  Simultaneous hypercrosslinking and functionalization of porous polystyrene adsorbent for protein-bound uraemic toxins removal.  REACTIVE & FUNCTIONAL POLYMERS,      [PMID:] [10.1016/j.reactfunctpolym.2025.106265]