N6-Methyladenosine - 10mM in DMSO , CAS No.1867-73-8

CAS: 1867-73-8 Cat. No.: N422283 Summenformel: C₁₁H₁₅N₅O₄ Molekulargewicht: 281.27

GRADE & PURITY 10mM in DMSO

Synonyms

Reserpene | 6-methylamino-9-beta-D-ribofuranosyl-Purine | NCGC00162241-09 | PDSP2_001014 | BP-58658 | CHEBI:21891 | s3190 | Purine, 6-methylamino-9-beta-D-ribofuranosyl- | SCHEMBL40634 | Q6951996 | 6-Methylaminopurinosine | cid_5775 | NCGC00162241-02 | BB

Storage

Store at -80°C

Shipped In

Dry ice packs + Cold packs

Specifications

Synonyme

Reserpene | 6-methylamino-9-beta-D-ribofuranosyl-Purine | NCGC00162241-09 | PDSP2_001014 | BP-58658 | CHEBI:21891 | s3190 | Purine, 6-methylamino-9-beta-D-ribofuranosyl- | SCHEMBL40634 | Q6951996 | 6-Methylaminopurinosine | cid_5775 | NCGC00162241-02 | BB

Spezifikationen & Reinheit

10mM in DMSO

Biochemische und physiologische Mechanismen

Modified base. Adenosine analog methylated at the nitrogen-6 position. Abundant modification in mRNA, found within some viruses, and most eukaryotes including mammals, insects, plants and yeast. Also found in tRNA, rRNA, and small nuclear RNA (snRNA).

Storage

Store at -80°C

Verschickt in

Dry ice packs + Cold packs

Dieses Produkt erfordert Kühlkettenversand. Grundversand und andere Economy-Optionen sind nicht verfügbar.

Aktionsart

INHIBITOR

Namen und Kennungen

Pubchem Sid

528766238

Kanonisches Lächeln

CNC1=C2C(=NC=N1)N(C=N2)C3C(C(C(O3)CO)O)O

IUPAC Name

(2R,3S,4R,5R)-2-(hydroxymethyl)-5-[6-(methylamino)purin-9-yl]oxolane-3,4-diol

InChIKey

VQAYFKKCNSOZKM-IOSLPCCCSA-N

INCHI

1S/C11H15N5O4/c1-12-9-6-10(14-3-13-9)16(4-15-6)11-8(19)7(18)5(2-17)20-11/h3-5,7-8,11,17-19H,2H2,1H3,(H,12,13,14)/t5-,7-,8-,11-/m1/s1

Isomere SMILES

CNC1=C2C(=NC=N1)N(C=N2)[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O)O

Molekulargewicht

281.27

Reaxy-Rn

1225398

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1225398&ln=

Taxonomic Classification

Taxonomy Tree

• Kingdom Organic compounds
  • Superclass Nucleosides, nucleotides, and analogues
    • Klasse Purine nucleosides

• Kingdom: Organic compounds
• Superclass: Nucleosides, nucleotides, and analogues
• Klasse: Purine nucleosides
• Subclass: Not available
• Intermediate Tree Nodes: Not available
• Direct Parent: Purine nucleosides
• Alternative Parents: Glycosylamines 6-alkylaminopurines Pentoses Secondary alkylarylamines Aminopyrimidines and derivatives N-substituted imidazoles Imidolactams Tetrahydrofurans Heteroaromatic compounds Secondary alcohols Oxacyclic compounds Azacyclic compounds Primary alcohols Organopnictogen compounds Hydrocarbon derivatives
• Molecular Framework: Aromatic heteropolycyclic compounds
• Substituents: Purine nucleoside - Glycosyl compound - N-glycosyl compound - 6-alkylaminopurine - 6-aminopurine - Pentose monosaccharide - Imidazopyrimidine - Purine - Aminopyrimidine - Secondary aliphatic/aromatic amine - Monosaccharide - N-substituted imidazole - Pyrimidine - Imidolactam - Tetrahydrofuran - Azole - Imidazole - Heteroaromatic compound - Secondary alcohol - Organoheterocyclic compound - Azacycle - Secondary amine - Oxacycle - Amine - Organic nitrogen compound - Alcohol - Hydrocarbon derivative - Organopnictogen compound - Organonitrogen compound - Organooxygen compound - Organic oxygen compound - Primary alcohol - Aromatic heteropolycyclic compound
• Beschreibung: This compound belongs to the class of organic compounds known as purine nucleosides. These are compounds comprising a purine base attached to a ribosyl or deoxyribosyl moiety.
• External Descriptors: methyladenosine

Data sources

1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.

DOI: 10.1186/s13321-016-0174-y

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ADORA3 Tchem Adenosine receptor A3 (1 Activities)

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ADORA1 Tclin Adenosine A1 receptor (17603 Activities)

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ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)

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AVPR1B Tclin Vasopressin V1b receptor (1301 Activities)

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ADORA2A Tclin Adenosine A2a receptor (16305 Activities)

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ADORA2B Tclin Adenosine A2b receptor (7672 Activities)

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ADORA3 Tchem Adenosine A3 receptor (15931 Activities)

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ARSA Tbio Cerebroside-sulfatase (655 Activities)

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HSP90AA1 Tchem Heat shock protein HSP 90-alpha (4115 Activities)

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HT-29 (80576 Activities)

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K562 (73714 Activities)

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MCF7 (126967 Activities)

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HEK293 (82097 Activities)

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EHMT2 Tchem Histone-lysine N-methyltransferase, H3 lysine-9 specific 3 (93046 Activities)

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HSP90B1 Tchem Endoplasmin (514 Activities)

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TDP1 Tchem Tyrosyl-DNA phosphodiesterase 1 (345557 Activities)

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ERG Tbio Transcriptional regulator ERG (5589 Activities)

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SMAD3 Tchem Mothers against decapentaplegic homolog 3 (68039 Activities)

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RXFP1 Tchem Relaxin receptor 1 (6345 Activities)

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RXFP2 Tbio Relaxin receptor 2 (377 Activities)

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CBX1 Tbio Chromobox protein homolog 1 (92434 Activities)

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ATAD5 Tbio ATPase family AAA domain-containing protein 5 (122566 Activities)

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ATXN2 Tbio Ataxin-2 (54410 Activities)

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USP1 Tchem Ubiquitin carboxyl-terminal hydrolase 1 (22556 Activities)

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ADAL Tbio Adenosine deaminase-like protein (61 Activities)

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PGK1 Tchem Phosphoglycerate kinase (287 Activities)

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ADORA1 Tclin Adenosine receptor (26 Activities)

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YTHDF2 Tbio YTH domain-containing family protein 2 (23 Activities)

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Hdac6 Histone deacetylase 6 (222 Activities)

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Plasmodium falciparum (966862 Activities)

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J774.A1 (2436 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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pfk 6-phospho-1-fructokinase (7870 Activities)

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Txnrd1 Thioredoxin reductase 1, cytoplasmic (45279 Activities)

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Bacillus anthracis (2936 Activities)

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Adora2b Adenosine A2 receptor (1828 Activities)

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Tick-borne encephalitis virus (132 Activities)

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SARS-CoV-2 (38078 Activities)

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Wirkungsmechanismen

Chemische und physikalische Eigenschaften

• Molekulargewicht: 281.270 g/mol
• XLogP3: -0.400
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 3
• Exact Mass: 281.112 Da
• Monoisotopic Mass: 281.112 Da
• Topological Polar Surface Area: 126.000 Ų
• Heavy Atom Count: 20
• Formal Charge: 0
• Complexity: 349.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 4
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 1