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· · COA & SDS available for every product · Same-day shipping on in-stock items Navarixin (SCH-527123) - Moligand™, ≥98% , Interleukin-8 receptor A antagonist, CAS No.473727-83-2, Interleukin-8 receptor A antagonist
GRADE & PURITY Moligand™ ? Moligand™ — Aladdin's line of ligands and bioactive small molecules. Use for receptor, pathway, and binding studies needing defined small-molecule tools. ≥98% Synonyms
Navarixin | SCH 527123,CAS:473727-83-2 | s8506 | (R)-2-hydroxy-N,N-dimethyl-3-(2-(1-(5-methylfuran-2-yl)propylamino)-3,4-dioxocyclobut-1-enylamino)benzamide | AC-33600 | Sch527123 | YTA72783 | Q27087854 | SCH 527123 | 2-hydroxy-N,N-dimethyl-3-{2-[[(R)-1-(
Shipped In
Ice chest + Ice pads
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Why this grade Moligand™, ≥98% Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview Information
Navarixin (SCH-527123) Navarixin (SCH-527123, MK-7123, PS-291822) is a potent, orally bioavailable CXCR2/CXCR1 antagonist with IC50 values of 2.6 nM and 36 nM, respectively.
Targets
CXCR2 (Cell-free assay); CXCR1 (Cell-free assay) 2.6 nM; 36 nM
Specifications Synonyms
Navarixin | SCH 527123, CAS:473727-83-2 | s8506 | (R)-2-hydroxy-N, N-dimethyl-3-(2-(1-(5-methylfuran-2-yl)propylamino)-3, 4-dioxocyclobut-1-enylamino)benzamide | AC-33600 | Sch527123 | YTA72783 | Q27087854 | SCH 527123 | 2-hydroxy-N, N-dimethyl-3-{2-[[(R)-1-(
Specifications & Purity
Moligand™, ≥98%
Biochemical and Physiological Mechanisms
Navarixin (SCH-527123, MK-7123, PS-291822) is a potent, orally bioavailable CXCR2/CXCR1 antagonist with IC50 values of 2.6 nM and 36 nM, respectively.
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Mechanism of action
Interleukin-8 receptor A antagonist
Product Properties ALogP 1.635 hba_count 4 HBD Count 3 Rotatable Bond 7
Names and Identifiers Pubchem Sid 504765011 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504765011 Canonical Smiles CCC(C1=CC=C(O1)C)NC2=C(C(=O)C2=O)NC3=CC=CC(=C3O)C(=O)N(C)C IUPAC Name 2-hydroxy-N,N-dimethyl-3-[[2-[[(1R)-1-(5-methylfuran-2-yl)propyl]amino]-3,4-dioxocyclobuten-1-yl]amino]benzamide InChIKey RXIUEIPPLAFSDF-CYBMUJFWSA-N INCHI 1S/C21H23N3O5/c1-5-13(15-10-9-11(2)29-15)22-16-17(20(27)19(16)26)23-14-8-6-7-12(18(14)25)21(28)24(3)4/h6-10,13,22-23,25H,5H2,1-4H3/t13-/m1/s1 Isomeric SMILES CC[C@H](C1=CC=C(O1)C)NC2=C(C(=O)C2=O)NC3=CC=CC(=C3O)C(=O)N(C)C Molecular Weight 397.42 Reaxy-Rn 15813721 Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=15813721&ln=
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Benzenoids Class Benzene and substituted derivatives Subclass Benzoic acids and derivatives Intermediate Tree Nodes Hydroxybenzoic acid derivatives - Salicylic acid and derivatives Direct Parent Aminosalicylic acids and derivatives Alternative Parents Aminobenzamides Salicylamides Benzamides o-Aminophenols Aniline and substituted anilines Benzoyl derivatives 1-hydroxy-4-unsubstituted benzenoids Aralkylamines Secondary alkylarylamines Primary aromatic amines Heteroaromatic compounds Furans Vinylogous amides Tertiary carboxylic acid amides Vinylogous acids Cyclic ketones Amino acids and derivatives Oxacyclic compounds Hydrocarbon derivatives Organic oxides Molecular Framework Aromatic heteromonocyclic compounds Substituents Aminosalicylic acid or derivatives - Aminobenzamide - Aminobenzoic acid or derivatives - Salicylamide - Benzamide - O-aminophenol - Aminophenol - Benzoyl - Aniline or substituted anilines - Aralkylamine - 1-hydroxy-4-unsubstituted benzenoid - Phenol - Secondary aliphatic/aromatic amine - Primary aromatic amine - Furan - Vinylogous amide - Vinylogous acid - Heteroaromatic compound - Tertiary carboxylic acid amide - Carboxamide group - Amino acid or derivatives - Cyclic ketone - Oxacycle - Carboxylic acid derivative - Secondary amine - Organoheterocyclic compound - Hydrocarbon derivative - Organic oxygen compound - Organic nitrogen compound - Organonitrogen compound - Amine - Organooxygen compound - Organic oxide - Aromatic heteromonocyclic compound Description This compound belongs to the class of organic compounds known as aminosalicylic acids and derivatives. These are salicylic acids or derivatives carrying an amino group on the benzene ring. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solubility Solubility (25°C) In vitro DMSO: 79 mg/mL (198.78 mM); Ethanol: 79 mg/mL (198.78 mM); Water: Insoluble; DMSO(mg / mL) Max Solubility 79 DMSO(mM) Max Solubility 198.78214483418 Water(mg / mL) Max Solubility ＜1 Molecular Weight 397.400 g/mol XLogP3 3.100 Hydrogen Bond Donor Count 3 Hydrogen Bond Acceptor Count 7 Rotatable Bond Count 7 Exact Mass 397.164 Da Monoisotopic Mass 397.164 Da Topological Polar Surface Area 112.000 Ų Heavy Atom Count 29 Formal Charge 0 Complexity 704.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 1 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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