Name: Nicotinamide - for cell culture, suitable for insect cell culture, ≥99.5%(HPLC), used for Nicotinamide has been used as a medium supplement in organoid culture of intestinal stem cells , esophageal squamous cell carcinomas(ESCC) pancreatic cancer organoi
Brand: Aladdin Scientific
SKU: N108087
Availability: InStock

Übersicht Spezifikationen Namen und Kennungen Dokumentation Erweiterte Daten Taxonomic Classification 3D-Struktur Zugehörige Ziele (menschlich) Zugehörige Ziele (nicht menschlich) Wirkungsmechanismen Zertifikate (CoA, COO, BSE/TSE und Analyse-Diagramm) Chemische und physikalische Eigenschaften FAQs und Artikel Citations of This Product Lösungsrechner Bewertungen

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Warum diese Qualität

for cell culture, suitable for insect cell culture, ≥99.5%(HPLC) für die Zellkultur,Geeignet für Insektenzellkulturen für empfindliche chromatographische und analytische Workflows, die minimale Basislinieninterferenzen erfordern.

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Lagerung & Versand

Room temperature,Desiccated Versand Normal. Genaue Spezifikationen finden Sie im chargenspezifischen COA.

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Qualitätsdokumente

SDS, COA, Datenblatt und Spezifikationsblatt stehen zum Download bereit. Chargenspezifische COA über Chargennummernsuche abrufbar.

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Literaturbeleg

In 85 peer-reviewten Publikationen zu Chromatographie, organischer Synthese und Kreuzkupplungsreaktionen zitiert.

Übersicht

Nicotinamide is a NAD+ and NADP+ coenzyme precursor. Nicotinamide is an antiinflammatory agent and a PARP-1 enzyme inhibitor.
An NAD+ and NADP+ coenzyme precursor

Spezifikationen

Synonyme

Spezifikationen & Reinheit

for cell culture, suitable for insect cell culture, ≥99.5%(HPLC)

Biochemische und physiologische Mechanismen

Amide form of vitamin B 3 . Plasma membrane and blood-brain barrier permeable. Precursor for β-nicotinamide adenine dinucleotide (NAD + ). Essential for the synthesis of NAD + phosphate (NADP + ). Essential for energy metabolism, normal physiology and dis

Anmeldung

Nicotinamide has been used as a medium supplement in organoid culture of intestinal stem cells , esophageal squamous cell carcinomas(ESCC) pancreatic cancer organoids and pancreatic progenitor induction.

Storage

Room temperature,Desiccated

Verschickt in

Normal

Note

für die Zellkultur, Geeignet für Insektenzellkulturen

Hinweis

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Refer to SDS for further information Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Reinheit

≥99.5%(HPLC)

Namen und Kennungen

Pubchem Sid

508814626

Pubchem Sid Url

https://pubchem.ncbi.nlm.nih.gov/substance/508814626

Kanonisches Lächeln

C1=CC(=CN=C1)C(=O)N

IUPAC Name

pyridine-3-carboxamide

InChIKey

DFPAKSUCGFBDDF-UHFFFAOYSA-N

INCHI

1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)

Isomere SMILES

C1=CC(=CN=C1)C(=O)N

WGK Deutschland

RTECS

QS3675000

Molekulargewicht

122.12

Beilstein

383619

Reaxy-Rn

383619

Reaxys-RN_link_address

https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=383619&ln=

Dokumentation

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Erweiterte Daten

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Organoheterocyclic compounds
  - Klasse Pyridines and derivatives
    - Subclass Pyridinecarboxylic acids and derivatives
      - Ebene5 Pyridinecarboxamides
        Ebene6 Nicotinamides

Kingdom	Organic compounds
Superclass	Organoheterocyclic compounds
Klasse	Pyridines and derivatives
Subclass	Pyridinecarboxylic acids and derivatives
Intermediate Tree Nodes	Pyridinecarboxamides
Direct Parent	Nicotinamides
Alternative Parents	Heteroaromatic compounds Primary carboxylic acid amides Azacyclic compounds Organopnictogen compounds Organooxygen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives
Molecular Framework	Aromatic heteromonocyclic compounds
Substituents	Nicotinamide - Heteroaromatic compound - Primary carboxylic acid amide - Carboxamide group - Azacycle - Carboxylic acid derivative - Organic nitrogen compound - Organic oxygen compound - Organopnictogen compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organonitrogen compound - Aromatic heteromonocyclic compound
Beschreibung	This compound belongs to the class of organic compounds known as nicotinamides. These are heterocyclic aromatic compounds containing a pyridine ring substituted at position 3 by a carboxamide group.
External Descriptors	a vitamin - an aliphatic amide
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D-Struktur

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PDE5A Tclin Phosphodiesterase 5A (5113 Activities)

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EGFR Tclin Epidermal growth factor receptor erbB1 (33727 Activities)

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F2 Tclin Thrombin (11687 Activities)

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CA2 Tclin Carbonic anhydrase II (17698 Activities)

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ESR1 Tclin Estrogen receptor alpha (17718 Activities)

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HMGCR Tclin HMG-CoA reductase (2475 Activities)

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NR3C1 Tclin Glucocorticoid receptor (14987 Activities)

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INSR Tclin Insulin receptor (5558 Activities)

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PGR Tclin Progesterone receptor (8562 Activities)

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ADRB2 Tclin Beta-2 adrenergic receptor (11824 Activities)

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CHRM2 Tclin Muscarinic acetylcholine receptor M2 (10671 Activities)

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ADRB1 Tclin Beta-1 adrenergic receptor (6630 Activities)

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HTR1A Tclin Serotonin 1a (5-HT1a) receptor (14969 Activities)

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ADRA2A Tclin Alpha-2a adrenergic receptor (9450 Activities)

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AR Tclin Androgen Receptor (11781 Activities)

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CHRM1 Tclin Muscarinic acetylcholine receptor M1 (12690 Activities)

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ACE Tclin Angiotensin-converting enzyme (1423 Activities)

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DRD2 Tclin Dopamine D2 receptor (23596 Activities)

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TYR Tclin Tyrosinase (717 Activities)

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MAOA Tclin Monoamine oxidase A (11911 Activities)

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CNR1 Tclin Cannabinoid CB1 receptor (20913 Activities)

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DRD1 Tclin Dopamine D1 receptor (9720 Activities)

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DRD4 Tchem Dopamine D4 receptor (7907 Activities)

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ACHE Tclin Acetylcholinesterase (18204 Activities)

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PTGS1 Tclin Cyclooxygenase-1 (9233 Activities)

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SLC6A2 Tclin Norepinephrine transporter (10102 Activities)

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HRH2 Tclin Histamine H2 receptor (5428 Activities)

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ADRA1D Tclin Alpha-1d adrenergic receptor (4171 Activities)

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HTR1B Tclin Serotonin 1b (5-HT1b) receptor (2801 Activities)

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HTR2A Tclin Serotonin 2a (5-HT2a) receptor (14758 Activities)

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HTR2C Tclin Serotonin 2c (5-HT2c) receptor (11471 Activities)

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ADORA1 Tclin Adenosine A1 receptor (17603 Activities)

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CALCR Tclin Calcitonin receptor (2215 Activities)

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SLC6A4 Tclin Serotonin transporter (12625 Activities)

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ADRA1A Tclin Alpha-1a adrenergic receptor (8359 Activities)

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PTGS2 Tclin Cyclooxygenase-2 (13999 Activities)

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HRH1 Tclin Histamine H1 receptor (7573 Activities)

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ADRA1B Tclin Alpha-1b adrenergic receptor (2912 Activities)

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OPRM1 Tclin Mu opioid receptor (19785 Activities)

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DRD3 Tclin Dopamine D3 receptor (14368 Activities)

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AVPR1A Tclin Vasopressin V1a receptor (5412 Activities)

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OPRD1 Tclin Delta opioid receptor (15096 Activities)

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OPRK1 Tclin Kappa opioid receptor (16155 Activities)

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SLC6A3 Tclin Dopamine transporter (10535 Activities)

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KCNH2 Tclin HERG (29587 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HTR4 Tclin Serotonin 4 (5-HT4) receptor (2068 Activities)

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PDE3A Tclin Phosphodiesterase 3A (3309 Activities)

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ESR2 Tclin Estrogen receptor beta (9272 Activities)

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CYSLTR1 Tclin Cysteinyl leukotriene receptor 1 (2118 Activities)

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ERBB2 Tclin Receptor protein-tyrosine kinase erbB-2 (7851 Activities)

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Agtr2 Angiotensin II type 2 (AT-2) receptor (803 Activities)

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Mc4r Melanocortin receptor 4 (1205 Activities)

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Ltc4s Leukotriene C4 synthase (1 Activities)

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Sigmar1 Sigma opioid receptor (160 Activities)

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Npy1r Neuropeptide Y receptor type 1 (8 Activities)

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Cckar Cholecystokinin A receptor (90 Activities)

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Nos2 Nitric oxide synthase, inducible (3573 Activities)

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Mapk1 MAP kinase ERK2 (650 Activities)

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Hdac6 Histone deacetylase 6 (222 Activities)

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Faah Anandamide amidohydrolase (3907 Activities)

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Mmp9 Matrix metalloproteinase 9 (38 Activities)

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SIR2 NAD-dependent histone deacetylase SIR2 (218 Activities)

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Pseudomonas aeruginosa (123386 Activities)

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Klebsiella pneumoniae (43867 Activities)

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Staphylococcus aureus (210822 Activities)

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Acinetobacter baumannii (41033 Activities)

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Escherichia coli (133304 Activities)

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Leishmania infantum (5912 Activities)

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Plasmodium falciparum (966862 Activities)

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Cryptococcus neoformans (21258 Activities)

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Candida albicans (78123 Activities)

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Leishmania donovani (89745 Activities)

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Trypanosoma cruzi (99888 Activities)

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Toxoplasma gondii (4585 Activities)

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Rattus norvegicus (775804 Activities)

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Trypanosoma brucei rhodesiense (7991 Activities)

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RAW264.7 (28094 Activities)

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panE Ketopantoate reductase (28 Activities)

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GCN5 Histone acetyltransferase GCN5 (89 Activities)

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rep Replicase polyprotein 1ab (378 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

HST2 NAD-dependent deacetylase HST2 (97 Activities)

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Plasma (328 Activities)

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SIR2RP1 Putative silent information regulator 2 (21 Activities)

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Activity Type	Relation	Activity value	Units	Action Type	Journal	PubMed Id	doi	Assay Aladdin ID

cobB NAD-dependent protein deacetylase (1 Activities)

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Glra2 Glycine receptor (1745 Activities)

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SARS-CoV-2 (38078 Activities)

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Sarm1 NAD(+) hydrolase SARM1 (23 Activities)

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Wirkungsmechanismen

Zertifikate (CoA, COO, BSE/TSE und Analyse-Diagramm)

C of A & Other Certificates(BSE/TSE, COO):

Analytical Chart:

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13 results found

Lot Number	Certificate Type	Datum	Artikel
E2622148	Certificate of Analysis	Jun 01, 2026	N108087
E2622149	Certificate of Analysis	Jun 01, 2026	N108087
K2504001	Certificate of Analysis	Nov 08, 2025	N108087
K2504012	Certificate of Analysis	Nov 08, 2025	N108087
B2525348	Certificate of Analysis	Dec 14, 2024	N108087
B2525349	Certificate of Analysis	Dec 14, 2024	N108087
B2309199	Certificate of Analysis	Jun 25, 2022	N108087
G2222535	Certificate of Analysis	Jun 25, 2022	N108087
G2222642	Certificate of Analysis	Jun 25, 2022	N108087
H2317080	Certificate of Analysis	Jun 25, 2022	N108087
K2429108	Certificate of Analysis	Jun 25, 2022	N108087
K2503071	Certificate of Analysis	Jun 25, 2022	N108087
L2307178	Certificate of Analysis	Jun 25, 2022	N108087

Chemische und physikalische Eigenschaften

Löslichkeit	Soluble in water (1000 g/l) at 20 °C, ethanol (100 mM), glycerol (1 g/10ml), DMSO (100 mM), methanol, butanol, chloroform, and ether (Slightly).
Empfindlichkeit	light sensitive
Flammpunkt (°F)	302 °F
Flammpunkt (°C)	150 °C
Schmelzpunkt (°C)	128-131°C
Molekulargewicht	122.120 g/mol
XLogP3	-0.400
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	1
Exact Mass	122.048 Da
Monoisotopic Mass	122.048 Da
Topological Polar Surface Area	56.000 Å²
Heavy Atom Count	9
Formal Charge	0
Complexity	114.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

FAQs und Artikel

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REDOX NADPH ROS Signal Transduction metabolic enzymes energy metabolism NADH/NAD metabolite signaling flux analysis

Roles of One-Carbon Metabolism Enzymes in Oxidative Stress and Epigenetic Regulation in Cardiovascular Diseases

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Cardiovascular diseases one-carbon metabolism Oxidative Stress homocysteine transsulfuration pathway Nrf2 Folate Cycle Methionine Cycle Epigenetic Regulation S-Adenosylmethionine

Acetyl-Group Metabolic Enzyme Network and In Vitro Enzymology Analysis

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Epigenetic Regulation Acetyl-Group Metabolism Acetyl-Coa Acetyltransferases Deacetylases Pathway Analysis In Vitro Enzymology Central Carbon Metabolism

Noncanonical Functions of Epigenetic Enzymes and Regulation of Mitochondrial Metabolism

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epigenetic enzymes noncanonical functions mitochondrial metabolism mtDNA mitochondrial protein acetylation DNMT1 MOF LSD1

Three-Dimensional Chromatin Architecture Remodeling and Mechanisms of Physiological Aging

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three-dimensional chromatin physiological aging A/B compartments topologically associating domains chromatin loops lamina-associated domains heterochromatin

Understanding Ceramides from the Perspective of the Stratum Corneum Lipid Barrier: Moisturizing and Barrier-Repair Mechanisms, Ingredient Selection, and Formulation Research Considerations

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Nicotinamide Ceramides

Establishment and Evaluation Methods of Diabetic Animal Models

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diabetic animal modeling STZ-induced model alloxan model high-fat diet model HFD+STZ model NOD mice db/db mice ZDF rats

Mechanistic Analysis of Topical Glutathione in Skincare: Cellular Redox Regulation, Skin Delivery Challenges, and SLN-Based Delivery Strategies

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glutathione Cellular redox

Mechanism of Kojic Acid in Reducing Hyperpigmentation: From Tyrosinase Inhibition to Melanin Production Regulation

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Natural Pigment tyrosinase Melanin

Research on Cell Cycle and DNA Damage Response Mechanisms

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Cell Cycle DNA damage response G1/S checkpoint G2/M checkpoint ATM ATR Chk1 Chk2 CDK genome stability

If the DNA Sequence Remains Unchanged, Why Does Gene Expression Change? Core Mechanisms and Research Methods of Epigenetic Regulation

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DNA Epigenetics gene expression

Analysis of Hydrolyzed Pearl as a Cosmetic Raw Material: Preparation Process, Active Components, and Skincare Formulation Applications

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Hydrolyzed Pearl

The Dual-Targeted Skin-Brightening Mechanism of 4-MSK: Inhibiting Melanin Production and Reducing Epidermal Pigment Retention

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Potassium 4-Methoxysalicylate 4-MSK INCI

Antioxidant Mechanisms, Stability, and Delivery Strategies of Resveratrol in Skincare Research

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Resveratrol

Probiotics, Prebiotics, and Postbiotics in Skin Care: Conceptual Distinctions, Mechanisms of Action, and Their Applications in the Care of Dry, Itchy, and Rough Skin

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skin care Probiotics

How Do Collagen Peptides Act on the Skin? From Surface Hydration and Percutaneous Delivery to Fibroblasts and Collagen Homeostasis

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skin care collagen peptide

Phenylethyl Resorcinol (377): Structural Characteristics, Melanogenesis-Regulating Mechanisms, and Related Applications in Formulation Research

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cosmetics Phenylethyl Resorcinol

Potential Mechanisms of Succinic Acid in Acne Care: From Dicarboxylic Acid–Base Equilibria to Metabolic Antagonism Among Skin Microorganisms

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Succinic Acid Acne

Anti-Photoaging Potential of Artemia Extract: UV-Induced Damage Cascades, HSP70-Related Stress Protection, and GP4G Metabolic Insights

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Artemia Extract UV-Induced Damage

Regulatory Mechanisms, Research Methods, and Modification-Omics Analysis of Protein Post-Translational Modifications

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Glycosylation methylation SUMOylation Protein Post-Translational Modifications Ubiquitination Phosphorylation Acetylation Lactylation Modification Proteomics

The Sebum-Regulating Potential of Zinc PCA and Its Relationship with Stratum Corneum Hydration

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Sebum regulation Zinc PCA Sebaceous gland

Mechanism of Action of Tranexamic Acid in Pigmentation Care: From the Plasmin System to Regulation of Inflammation-Driven Pro-Melanogenic Signaling

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Tranexamic Acid TXA

How Arbutin Regulates Melanin Production: α/β Anomeric Configuration and Tyrosinase Action

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Melanin Arbutin

Mechanisms of Action, Formulation Screening, and Safety Evaluation of Solubilizers, Hydrotropes, and Cosolvents in Drug-Delivery Systems

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Surfactants solubilizers hydrotropes cosolvents poorly soluble drugs micellar solubilization hydrotropy mixed solvents dilution-induced precipitation drug-delivery formulations

Regulatory Mechanisms of Aging-Related Nutrient Sensing, Inflammation, and Homeostatic Signaling Pathways

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Autophagy Aging mTOR AMPK senescence-associated secretory phenotype IIS IGF-1 Sirtuins

Mechanistic Basis of Acetyl Hexapeptide-8 in the Management of Expression Lines: SNARE Complex Interference, Constraints on Percutaneous Delivery, and Combination Strategies

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Retinol Acetyl Hexapeptide-8 Argireline SNAP-25 SNARE complex expression lines transdermal delivery anti-wrinkle combinations

Niacinamide Brightening Mechanisms and Formulation Design: Melanosome Transfer, pH Regulation, and Combination Strategies

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Niacinamide

Molecular Mechanisms by Which Natural Products Regulate Adipose Browning

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Natural products AMPK adipose browning white adipose tissue UCP1 PGC-1α Hyperforin non-shivering thermogenesis

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Nicotinamide - for cell culture, suitable for insect cell culture, ≥99.5%(HPLC), used for Nicotinamide has been used as a medium supplement in organoid culture of intestinal stem cells , esophageal squamous cell carcinomas(ESCC) pancreatic cancer organoi

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