Nonactin from Streptomyces griseus var griseus - Moligand™, ≥96%, A mixture of Nonactin, Monactin and Dinactin , CAS No.6833-84-7

CAS: 6833-84-7 Cat. No.: N139792 Molecular Weight: 736.93 (for Nonactin)

4 Citations COA

Skip to the end of the images gallery

Nonactin from Streptomyces griseus var griseus - Moligand™, ≥96%, A mixture of Nonactin, Monactin and Dinactin CAS No(6833-84-7) by Aladdin Scientific

Skip to the beginning of the images gallery

AVAILABLE TO ORDER

GRADE & PURITY Moligand™ ? ≥96% A mixture of Nonactin, Monactin and Dinactin

Synonyms

Ferricon | NSC52141 | NSC-52141 | 4,13,22,31,37,38,39,40-OCTAOXAPENTACYCLO(32.2.1.17,10.116,19.125,28)TETRACONTANE-3,12,21,30-TETRONE, 2,5,11,14,20,23,29,32-OCTAMETHYL-, (1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)- | NSC 56409 | Q7049170

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Overview Specifications Names and Identifiers Documentation Advanced Data Taxonomic Classification 3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Citations of This Product References Solution Calculators Reviews

🧪

Why this grade

Moligand™, ≥96%, A mixture of Nonactin, Monactin and Dinactin Moligand™ for sensitive chromatographic and analytical workflows requiring minimal baseline interference.

🌡

Storage & shipping

Store at -20°C,Argon charged Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.

📋

Quality documents

SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.

📚

Literature proof

Cited in 4 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.

Overview

Nonactin from Streptomyces Griseus: a mixture of the two homolog macrotetrolide antibiotics: Nonactin, Monactin. The Nonactin is not less than 80%, ballanced by Monactin only. The mixture does not contain Dinactin, Trinactin, Tetranactin. Nonactin batches released since May 2010 are better than 95% Nonactin by NMR; detailed information is available on request
Nonactin has an inhibitory effects on the P170 glycoprotein-mediated efflux of chemotherapeutic agents in multiple-drug-resistant cancer cells. Nonactin, a natural mixture of macrotetrolides, was used in agriculture under the name trade POLYNACTIN. Nonactin has been reported to specifically inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria. Nonactin is used in urea and ammonium specific electrodes.

Specifications

Synonyms

Ferricon | NSC52141 | NSC-52141 | 4, 13, 22, 31, 37, 38, 39, 40-OCTAOXAPENTACYCLO(32.2.1.17, 10.116, 19.125, 28)TETRACONTANE-3, 12, 21, 30-TETRONE, 2, 5, 11, 14, 20, 23, 29, 32-OCTAMETHYL-, (1R, 2R, 5R, 7R, 10S, 11S, 14S, 16S, 19R, 20R, 23R, 25R, 28S, 29S, 32S, 34S)- | NSC 56409 | Q7049170

Specifications & Purity

Moligand™, ≥96%, A mixture of Nonactin, Monactin and Dinactin

Biochemical and Physiological Mechanisms

Nonactin is a macrotetrolide that forms complexes with alkali cations, such as potassium and sodium. Nonactin has been reported to inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria. Nonactin is a uncoupler of oxidative

Storage

Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Note

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

Purity

≥96%

Names and Identifiers

Canonical Smiles	CC1CC2CCC(O2)C(C(=O)OC(CC3CCC(O3)C(C(=O)OC(CC4CCC(O4)C(C(=O)OC(CC5CCC(O5)C(C(=O)O1)C)C)C)C)C)C)C
IUPAC Name	(1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-2,5,11,14,20,23,29,32-octamethyl-4,13,22,31,37,38,39,40-octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone
InChIKey	RMIXHJPMNBXMBU-QIIXEHPYSA-N
INCHI	1S/C40H64O12/c1-21-17-29-9-13-34(49-29)26(6)38(42)46-23(3)19-31-11-15-36(51-31)28(8)40(44)48-24(4)20-32-12-16-35(52-32)27(7)39(43)47-22(2)18-30-10-14-33(50-30)25(5)37(41)45-21/h21-36H,9-20H2,1-8H3/t21-,22+,23+,24-,25-,26+,27+,28-,29-,30+,31+,32-,33-,34+,35+,36-
Isomeric SMILES	C[C@@H]1C[C@H]2CC[C@H](O2)[C@@H](C(=O)O[C@H](C[C@@H]3CC[C@@H](O3)[C@H](C(=O)O[C@@H](C[C@H]4CC[C@H](O4)[C@@H](C(=O)O[C@H](C[C@@H]5CC[C@@H](O5)[C@H](C(=O)O1)C)C)C)C)C)C)C
WGK Germany	3
Molecular Weight	736.93 (for Nonactin)
Reaxy-Rn	1278987
Reaxys-RN_link_address	https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=1278987&ln=

Documentation

📋 Safety Data Sheet (SDS)

Comprehensive hazard, handling, storage, and regulatory compliance document.

Download SDS →

✅ Certificate of Analysis (COA)

Lot-specific quality data. Enter your lot number to retrieve the exact COA.

Look up COA →

📊 Datasheet

Quick-reference summary of product specifications and applications.

View datasheet →

🔬 Specification Sheet

Full quality attributes and acceptance criteria for this grade.

View spec sheet →

Advanced Data

Taxonomic Classification

Taxonomy Tree

Kingdom Organic compounds
- Superclass Phenylpropanoids and polyketides
  - Class Macrolides and analogues

Kingdom	Organic compounds
Superclass	Phenylpropanoids and polyketides
Class	Macrolides and analogues
Subclass	Not available
Intermediate Tree Nodes	Not available
Direct Parent	Macrolides and analogues
Alternative Parents	Tetracarboxylic acids and derivatives Tetrahydrofurans Lactones Carboxylic acid esters Oxacyclic compounds Dialkyl ethers Organic oxides Hydrocarbon derivatives Carbonyl compounds
Molecular Framework	Aliphatic heteropolycyclic compounds
Substituents	Macrolide - Tetracarboxylic acid or derivatives - Tetrahydrofuran - Carboxylic acid ester - Lactone - Carboxylic acid derivative - Dialkyl ether - Ether - Oxacycle - Organoheterocyclic compound - Organic oxide - Hydrocarbon derivative - Organooxygen compound - Organic oxygen compound - Carbonyl group - Aliphatic heteropolycyclic compound
Description	This compound belongs to the class of organic compounds known as macrolides and analogues. These are organic compounds containing a lactone ring of at least twelve members.
External Descriptors	macrolide
1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61. DOI: 10.1186/s13321-016-0174-y

3D Structure

Associated Targets(Human)

A498 (42825 Activities)

Lot Number	Certificate Type	Date	Item
C2612728	Certificate of Analysis	Jan 19, 2026	N139792
C2612729	Certificate of Analysis	Jan 19, 2026	N139792
C2612730	Certificate of Analysis	Jan 19, 2026	N139792
G2509595	Certificate of Analysis	Jul 04, 2025	N139792
G2509589	Certificate of Analysis	Jul 04, 2025	N139792
G2509584	Certificate of Analysis	Jul 04, 2025	N139792
J2418650	Certificate of Analysis	Oct 09, 2024	N139792
J2418649	Certificate of Analysis	Oct 09, 2024	N139792
J2418648	Certificate of Analysis	Oct 09, 2024	N139792
A2305649	Certificate of Analysis	Oct 11, 2022	N139792
A2305575	Certificate of Analysis	Oct 11, 2022	N139792
A2305573	Certificate of Analysis	Oct 11, 2022	N139792
J2218937	Certificate of Analysis	Jul 20, 2022	N139792
J2218938	Certificate of Analysis	Jul 20, 2022	N139792
J2218946	Certificate of Analysis	Jul 20, 2022	N139792
B2215657	Certificate of Analysis	Jan 17, 2022	N139792
B2215652	Certificate of Analysis	Jan 17, 2022	N139792
B2215648	Certificate of Analysis	Jan 17, 2022	N139792

Solubility	Soluble in chloroform (9.80 - 10.20 mg/ml), ethanol (10 mM), DMSO (10 mg/ml), and methanol. Insoluble in water.
Sensitivity	moisture sensitive
Melt Point(°C)	145℃-146℃
Molecular Weight	736.900 g/mol
XLogP3	6.600
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	0
Exact Mass	736.44 Da
Monoisotopic Mass	736.44 Da
Topological Polar Surface Area	142.000 Å²
Heavy Atom Count	52
Formal Charge	0
Complexity	1040.000
Isotope Atom Count	0
Defined Atom Stereocenter Count	16
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
The total count of all stereochemical bonds	0
Covalently-Bonded Unit Count	1

Nonactin from Streptomyces griseus var griseus - Moligand™, ≥96%, A mixture of Nonactin, Monactin and Dinactin , CAS No.6833-84-7

Why this grade

Storage & shipping

Quality documents

Literature proof

Overview

Specifications

Documentation

📋 Safety Data Sheet (SDS)

✅ Certificate of Analysis (COA)

📊 Datasheet

🔬 Specification Sheet

Advanced Data

Show more ⌵

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

Customer Reviews

Need help choosing the grade?

View related series