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· · COA & SDS available for every product · Same-day shipping on in-stock items NVP-BAG956 - ≥95% , CAS No.853910-02-8
Synonyms
EX-A875 | NVP-BAG956(BAG 956) | 2-methyl-2-(4-(2-methyl-8-(pyridin-3-ylethynyl)-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile | MS-27556 | 2-Methyl-2-[4-(2-methyl-8-pyridin-3-ylethynyl-imidazo[4,5-c]quinolin-1-yl)-phenyl]-propionitrile | BENZENEACE
Shipped In
Ice chest + Ice pads
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Why this grade ≥95% for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping Store at -20°C Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
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Quality documents SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Specifications Synonyms
EX-A875 | NVP-BAG956(BAG 956) | 2-methyl-2-(4-(2-methyl-8-(pyridin-3-ylethynyl)-1H-imidazo[4, 5-c]quinolin-1-yl)phenyl)propanenitrile | MS-27556 | 2-Methyl-2-[4-(2-methyl-8-pyridin-3-ylethynyl-imidazo[4, 5-c]quinolin-1-yl)-phenyl]-propionitrile | BENZENEACE
Specifications & Purity
≥95%
Biochemical and Physiological Mechanisms
Dual PDPK1 (PDK1) and class I PI 3-K inhibitor (IC50values are 245, 56, 446, 35 and 117 nM for PDPK1 and PI 3-K p110 -α, -β, -δ, and -γrespectively). Inhibits cellular AKT phosphorylation at Thr308. Blocks cell proliferation, causing arrest in G1phase of
Shipped In
Ice chest + Ice pads
This product requires cold chain shipping. Ground and other economy services are not available.
Names and Identifiers Pubchem Sid 504769893 Pubchem Sid Url https://pubchem.ncbi.nlm.nih.gov/substance/504769893 Canonical Smiles CC1=NC2=CN=C3C=CC(=CC3=C2N1C4=CC=C(C=C4)C(C)(C)C#N)C#CC5=CN=CC=C5 IUPAC Name 2-methyl-2-[4-[2-methyl-8-(2-pyridin-3-ylethynyl)imidazo[4,5-c]quinolin-1-yl]phenyl]propanenitrile InChIKey GVPAGJWVBUZHNQ-UHFFFAOYSA-N INCHI 1S/C28H21N5/c1-19-32-26-17-31-25-13-8-20(6-7-21-5-4-14-30-16-21)15-24(25)27(26)33(19)23-11-9-22(10-12-23)28(2,3)18-29/h4-5,8-17H,1-3H3 Isomeric SMILES CC1=NC2=CN=C3C=CC(=CC3=C2N1C4=CC=C(C=C4)C(C)(C)C#N)C#CC5=CN=CC=C5 Molecular Weight 427.51 Reaxy-Rn 12307779 Reaxys-RN_link_address https://www.reaxys.com/reaxys/secured/hopinto.do?context=S&query=IDE.XRN=12307779&ln=
Documentation 📋 Safety Data Sheet (SDS) Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS → ✅ Certificate of Analysis (COA) Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA → 📊 Datasheet Quick-reference summary of product specifications and applications.
View datasheet → 🔬 Specification Sheet Full quality attributes and acceptance criteria for this grade.
View spec sheet →
Advanced Data Taxonomic Classification Kingdom Organic compounds Superclass Organoheterocyclic compounds Class Quinolines and derivatives Subclass Imidazoquinolines Intermediate Tree Nodes Not available Direct Parent Imidazoquinolines Alternative Parents Phenylimidazoles Phenylpropanes Imidazo-[4,5-c]pyridines Pyridines and derivatives N-substituted imidazoles Heteroaromatic compounds Nitriles Azacyclic compounds Hydrocarbon derivatives Molecular Framework Aromatic heteropolycyclic compounds Substituents Imidazoquinoline - 1-phenylimidazole - Imidazopyridine - Phenylpropane - Imidazo-[4,5-c]pyridine - Monocyclic benzene moiety - N-substituted imidazole - Pyridine - Benzenoid - Azole - Heteroaromatic compound - Imidazole - Nitrile - Carbonitrile - Azacycle - Hydrocarbon derivative - Cyanide - Organonitrogen compound - Organic nitrogen compound - Aromatic heteropolycyclic compound Description This compound belongs to the class of organic compounds known as imidazoquinolines. These are aromatic heterocyclic compounds containing an imidazole ring fused to a quinoline ring system. In some configurations, the imidazole ring shares a nitrogen atom with the quinoline moiety. External Descriptors Not available Data sources 1. Djoumbou Feunang Y, Eisner R, Knox C, Chepelev L, Hastings J, Owen G, Fahy E, Steinbeck C, Subramanian S, Bolton E, Greiner R, and Wishart DS. ClassyFire: Automated Chemical Classification With A Comprehensive, Computable Taxonomy. Journal of Cheminformatics, 2016, 8:61.
3D Structure Associated Targets(Human) Associated Targets(non-human) Mechanisms of Action Certificates（CoA,COO,BSE/TSE and Analysis Chart) Chemical and Physical Properties Solubility Solvent:DMSO, Max Conc. mg/mL: 17.1, Max Conc. mM: 40; Solvent:ethanol, Max Conc. mg/mL: 8.55, Max Conc. mM: 20 Molecular Weight 427.500 g/mol XLogP3 5.300 Hydrogen Bond Donor Count 0 Hydrogen Bond Acceptor Count 4 Rotatable Bond Count 4 Exact Mass 427.18 Da Monoisotopic Mass 427.18 Da Topological Polar Surface Area 67.400 Ų Heavy Atom Count 33 Formal Charge 0 Complexity 806.000 Isotope Atom Count 0 Defined Atom Stereocenter Count 0 Undefined Atom Stereocenter Count 0 Defined Bond Stereocenter Count 0 Undefined Bond Stereocenter Count 0 The total count of all stereochemical bonds 0 Covalently-Bonded Unit Count 1
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