p-Ethynylphenylalanine hydrochloride - ≥99% , CAS No.188640-63-3

CAS: 188640-63-3 Cat. No.: P647248 Molecular Weight: 225.67 EC Number: 192-891-9 PubChem CID: 127264445

GRADE & PURITY ≥99%

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Overview

p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine hydrochloride) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH) , with a K i of 32.6 μM

In Vitro

p-Ethynylphenylalanine hydrochloride selectively and reversibly inhibits the biosynthesis of serotonin. p-Ethynylphenylalanine hydrochloride has a low affinity for various recombinant 5-HT receptors (5-HT 1 , 5-HT 2 , 5-HT 4 , 5-HT 5 , 5-HT 6 , and 5-HT 7 ). MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

p-Ethynylphenylalanine hydrochloride (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue . p-Ethynylphenylalanine hydrochloride does not inhibit the aromatic amino acid decarboxylase . MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Male Sprague-Dawley rats (200 g) Dosage: 30 mg/kg Administration: Intraperitoneal injection Result: Decreased in 5-HT and 5-HIAA levels in the rat midbrain.

Form:Solid

IC50& Target:Ki: 32.6 μM (TPH)

Specifications

Specifications & Purity

≥99%

Biochemical and Physiological Mechanisms

p-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine hydrochloride) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH) , with a K i of 32.6 μM.

Storage

Store at 2-8°C, Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Purity

≥99%

Names and Identifiers

• Canonical Smiles: C#CC1=CC=C(C=C1)C[C@@H](C(=O)O)N.Cl
• Isomeric SMILES: C#CC1=CC=C(C=C1)C[C@@H](C(=O)O)N.Cl
• PubChem CID: 127264445
• Molecular Weight: 225.67

Chemical and Physical Properties

• Solubility: DMSO : 50 mg/mL (221.56 mM; ultrasonic and warming and heat to 60°C) H2O : 12.5 mg/mL (55.39 mM; Need ultrasonic)
• Molecular Weight: 225.670 g/mol
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 225.056 Da
• Monoisotopic Mass: 225.056 Da
• Topological Polar Surface Area: 63.300 Ų
• Heavy Atom Count: 15
• Formal Charge: 0
• Complexity: 245.000
• Isotope Atom Count: 0
• Defined Atom Stereocenter Count: 1
• Undefined Atom Stereocenter Count: 0
• Defined Bond Stereocenter Count: 0
• Undefined Bond Stereocenter Count: 0
• The total count of all stereochemical bonds: 0
• Covalently-Bonded Unit Count: 2

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