PDPH(3-(2-pyridyldithio)propionyl hydrazide) , CAS No.P638964

CAS: P638964 Cat. No.: P638964 Molecular Weight: 229.32

Storage

Store at 2-8°C,Desiccated

Shipped In

Wet ice

Overview

Product introduction：

PDPH is a short, pyridyldithiol-and-hydrazide crosslinker for reversibly conjugating sulfhydryls (cysteines) to carbonyls (aldehyde or ketones, such as those formed by oxidation of glycoprotein carbohydrates).

Features of PDPH :

• Reactive groups:pyridyldisulfide andhydrazide
• Reactive toward: sulfhydryl groups and carbonyl (aldehyde) groups
• Short (9.2A), sulfhydryl-to-aldehyde crosslinker with disulfide bond spacer arm (cleavable)
• Pyridyldithiol group results in attachment to sulfhydryls via disulfide bond, which can be cleaved with DTT, TCEP or other reducing agents
• Hydrazide group conjugates to oxidized sugars of glycoproteins and carbohydrates
• Usesodium meta-periodate to oxidize glycosylation (e.g., sialic acid) to reactive aldehyde groups
• Use withEDC to conjugate primary amine of hydrazide group to carboxyl groups

Product References:
Crosslinker Application Guide -- search for recent literature references for this product

• Reactive Moiety:Hydrazide,Pyridyldisulfide

• Crosslinker Type:Heterobifunctional

• Form:Powder:

• Spacer:Short(<10 Å),Cleavable:By Thiols

• Labeling Method:Chemical Labeling

• Spacer Arm Length:9.2 Å

Specifications

Storage

Store at 2-8°C, Desiccated

Shipped In

Wet ice

This product requires cold chain shipping. Ground and other economy services are not available.

Product Properties

• Reactivity: Carbohydrate-Sulfhydryl

Names and Identifiers

• Molecular Weight: 229.32

Chemical and Physical Properties

• Solubility: DMF,DMSO