10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
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Storage & shipping
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
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Quality documents
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
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Literature proof
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Overview
PF-06305591 is a potent and highly selective voltage gated sodium channel NaV1.8 blocker, with an IC 50 of 15 nM. An excellent preclinical in vitro ADME and safety profile
In Vitro
PF-06305591 (compound 9) has a highly attractive profile with respect to NaV selectivity, hERG activity, passive permeability and in vitro metabolic stability. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
In Vivo
PF-06305591 (compound 9) has good rat bioavailability. PF-06305591 offers the possibility of investigating higher IC 50 multiples of Nav1.8 blockade in the clinic, and therefore a more thorough evaluation of the role of NaV1.8 in the treatment of pain . MCE has not independently confirmed the accuracy of these methods. They are for reference only.
IC50& Target:Na v 1.8 15 nM (IC 50 )
Specifications
Specifications & Purity
10mM in DMSO
Biochemical and Physiological Mechanisms
PF-06305591 is a potent and highly selective voltage gated sodium channel NaV1.8 blocker, with an IC 50 of 15 nM. An excellent preclinical in vitro ADME and safety profile.
Storage
Store at -80°C
Shipped In
Dry ice packs + Cold packs
This product requires cold chain shipping. Ground and other economy services are not available.
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