≥98%(HPLC) for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -20°C,Desiccated Ships Ice chest + Ice pads Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 0 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
PF-543 hydrochloride (Sphingosine Kinase 1 Inhibitor II hydrochloride) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC50 of 2 nM and a Ki of 3.6 nM. PF-543 hydrochloride is >100-fold selectivity for SPHK1 over SPHK2. PF-543 hydrochloride is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC50 of 26.7 nM. PF-543 hydrochloride induces apoptosis, necrosis, and autophagy.
| Pubchem Sid | 504772916 |
|---|---|
| Pubchem Sid Url | https://pubchem.ncbi.nlm.nih.gov/substance/504772916 |
| Canonical Smiles | CC1=CC(=CC(=C1)OCC2=CC=C(C=C2)CN3CCCC3CO)CS(=O)(=O)C4=CC=CC=C4.Cl |
| IUPAC Name | [(2R)-1-[[4-[[3-(benzenesulfonylmethyl)-5-methylphenoxy]methyl]phenyl]methyl]pyrrolidin-2-yl]methanol;hydrochloride |
| InChIKey | WNKWAZFYPZMDGJ-VQIWEWKSSA-N |
| INCHI | 1S/C27H31NO4S.ClH/c1-21-14-24(20-33(30,31)27-7-3-2-4-8-27)16-26(15-21)32-19-23-11-9-22(10-12-23)17-28-13-5-6-25(28)18-29;/h2-4,7-12,14-16,25,29H,5-6,13,17-20H2,1H3;1H/t25-;/m1./s1 |
| PubChem CID | 121230770 |
| Molecular Weight | 502.07 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
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| Lot Number | Certificate Type | Date | Item |
|---|---|---|---|
 K2520142 | Certificate of Analysis | Dec 03, 2025 | P286792 |
| J2112645 | Certificate of Analysis | Jul 10, 2024 | P286792 |
| J2112646 | Certificate of Analysis | Jul 10, 2024 | P286792 |
| J2112647 | Certificate of Analysis | Jul 10, 2024 | P286792 |
| H2203555 | Certificate of Analysis | Aug 08, 2022 | P286792 |
| H2203559 | Certificate of Analysis | Aug 08, 2022 | P286792 |
| H2203560 | Certificate of Analysis | Aug 08, 2022 | P286792 |
| Solubility | The solution was in water, the highest concentration (mg/ml): 5.02, the highest concentration (mm): 10 mild heating; The highest concentration (mg/ml) was 100 and the highest concentration (mm) was 199.18; Dissolved in EtOH, maximum concentration (mg/ml): |
|---|---|
| Molecular Weight | 502.100 g/mol |
| XLogP3 | |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 5 |
| Rotatable Bond Count | 9 |
| Exact Mass | 501.174 Da |
| Monoisotopic Mass | 501.174 Da |
| Topological Polar Surface Area | 75.200 Ų |
| Heavy Atom Count | 34 |
| Formal Charge | 0 |
| Complexity | 679.000 |
| Isotope Atom Count | 0 |
| Defined Atom Stereocenter Count | 1 |
| Undefined Atom Stereocenter Count | 0 |
| Defined Bond Stereocenter Count | 0 |
| Undefined Bond Stereocenter Count | 0 |
| The total count of all stereochemical bonds | 0 |
| Covalently-Bonded Unit Count | 2 |
