PI3K/AKT-IN-1 - ≥99% , CAS No.P659144

CAS: P659144 Cat. No.: P659144 Molecular Weight: 465.52

GRADE & PURITY ≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

Overview

PI3K/AKT-IN-1 is an effective PI3K / AKT dual inhibitor ( IC 50 of 6.99, 4.01 and 3.36 μM for PI3Kγ , PI3Kδ and AKT , respectively). PI3K/AKT-IN-1 has anticancer activity and acts by inhibiting PI3K/AKT axis and inducing caspase 3 dependent apoptosis

Appearance:Solid

IC50& Target:PI3Kγ 6.99 μM (IC 50 ) PI3Kδ 4.01 μM (IC 50 )

In Vitro:PI3K/AKT-IN-1 (compound 7f) (0.04-100 µM; 48 hours) has high cytotoxic activity on both cell lines with better activity on leukaemia cell line (K562 IC 50 =2.62 µM) than on the breast cancer cell line (MCF-7 IC 50 =3.22 µM). PI3K/AKT-IN-1 (2.62 µM) c

In Vivo:PI3K/AKT-IN-1 (2000mg/kg; p.o.; single) is non-toxic and is well tolerated by experimental animals. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: Female rats (180-200g)Dosage: 2000

Biological Activity:PI3K/AKT-IN-1 is an effective PI3K / AKT dual inhibitor ( IC 50 of 6.99, 4.01 and 3.36 μM for PI3Kγ , PI3Kδ and AKT , respectively). PI3K/AKT-IN-1 has anticancer activity and acts by inhibiting PI3K/AKT axis and inducing caspase 3 dependent apoptosis

Specifications

Specifications & Purity

≥99%

Storage

Store at -20°C

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Action Type

INHIBITOR

Purity

≥99%

Names and Identifiers

• Molecular Weight: 465.52

Chemical and Physical Properties

• Solubility: DMSO : 50 mg/mL (107.41 mM; Need ultrasonic)