Pirtobrutinib - Moligand™, 10 mM in DMSO , CAS No.2101700-15-4

CAS: 2101700-15-4 Cat. No.: P1496102 Molecular Weight: 479.43 EC Number: 864-730-9 PubChem CID: 129269915

GRADE & PURITY Moligand™, 10 mM in DMSO

Storage

Argon charged,Store at -80°C

Shipped In

Dry ice packs + Cold packs

Overview

Pirtobrutinib (LOXO-305), a highly selective and non-covalent next generation BTK inhibitor, inhibits diverse BTK C481 substitution mutations. Pirtobrutinib causes regression of BTK-dependent lymphoma tumors in mouse xenograft models. Pirtobrutinib is also more than 300-fold selective for BTK versus 370 other kinases tested and shows no significant inhibition of non-kinase off-targets at 1 μM.

Specifications

Specifications & Purity

Moligand™, 10 mM in DMSO

Storage

Argon charged, Store at -80°C

Shipped In

Dry ice packs + Cold packs

This product requires cold chain shipping. Ground and other economy services are not available.

Grade

Moligand™

Action Type

INHIBITOR

Product Properties

• ALogP: 3.3

Names and Identifiers

• Isomeric SMILES: C[C@@H](C(F)(F)F)N1C(=C(C(=N1)C2=CC=C(C=C2)CNC(=O)C3=C(C=CC(=C3)F)OC)C(=O)N)N
• Alternate CAS: 2101700-15-4
• PubChem CID: 129269915
• MeSH Entry Terms: 5-amino-3-(4-(((5-fluoro-2-methoxybenzoyl)amino)methyl)phenyl)-1-((2S)-1,1,1-trifluoropropan-2-yl)pyrazole-4-carboxamide;LOXO-305;pirtobrutinib
• Molecular Weight: 479.43