Polyinosinic–polycytidylic acid sodium salt - ≥99%(TLC), less than 1% free nucleotides , CAS No.42424-50-0

CAS: 42424-50-0 Cat. No.: P170294 PubChem CID: 137229713

GRADE & PURITY ≥99%(TLC), less than 1% free nucleotides

Storage

Store at -20°C,Argon charged

Shipped In

Ice chest + Ice pads

Specifications

Specifications & Purity

≥99%(TLC), less than 1% free nucleotides

Biochemical and Physiological Mechanisms

Transfection of Poly (I: C) into NIT-1 cells has been used for intracellular dsRNA induction β A model of cell apoptosis. 18 hours after transfection, 45% of cells experienced apoptosis, and their NF kB, p50/p65 nuclear translocation, caspase 3 and 8 clea

Storage

Store at -20°C, Argon charged

Shipped In

Ice chest + Ice pads

This product requires cold chain shipping. Ground and other economy services are not available.

Note

Double-stranded homopolymer.The product requires ionic strength to maintain the double-strand structure. To prevent denaturation, reconstitute in solutions with physiological salt concentrations (e.g., saline solution). Reconstitution may require heating (50 °C) and cooling to achieve re-annealing.

Purity

≥99%(TLC)

Names and Identifiers

• Canonical Smiles: C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC2=C(C(=O)N1)N=CN2C3C(C(C(O3)COP(=O)(O)O)O)O.[Na]
• InChIKey: GETQKWBYQAUFQM-VRQAYDGLSA-N
• INCHI: 1S/C10H13N4O8P.C9H14N3O8P.Na/c15-6-4(1-21-23(18,19)20)22-10(7(6)16)14-3-13-5-8(14)11-2-12-9(5)17;10-5-1-2-12(9(15)11-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18;/h2-4,6-7,10,15-16H,1H2,(H,11,12,17)(H2,18,19,20);1-2,4,6-8,13-14H,3H2,(H2,10,11,15)(H2,16,17,18);/t4-,6-,7-,10-;4-,6-,7-,8-;/m11./s1
• PubChem CID: 137229713

Chemical and Physical Properties

• Solubility: H2O: 10 mg/mL
• Sensitivity: Moisture sensitive