10mM in DMSO for sensitive chromatographic and analytical workflows requiring minimal baseline interference.
Store at -80°C Ships Dry ice packs + Cold packs Check lot-specific COA for exact specifications.
SDS, COA, datasheet, and spec sheet available for download. Lot-specific COA accessible via lot number lookup.
Cited in 19 peer-reviewed publications across chromatography, organic synthesis, and cross-coupling reactions.
Information
Propranolol HCl (AY-64043, ICI-45520, NCS-91523) is a competitive non-selectivebeta-adrenergic receptorsinhibitor withIC50of 12 nM.
In vitro
In vivo
Cell Data
cell lines：
Concentrations：
Incubation Time：
Powder Purity:≥99%
| Isomeric SMILES | CC(C)NCC(COC1=CC=CC2=CC=CC=C21)O.Cl |
|---|---|
| Alternate CAS | 3506-09-0 |
| PubChem CID | 62882 |
| Molecular Weight | 295.81 |
Comprehensive hazard, handling, storage, and regulatory compliance document.
Download SDS →Lot-specific quality data. Enter your lot number to retrieve the exact COA.
Look up COA →Full quality attributes and acceptance criteria for this grade.
View spec sheet →| Solubility | Solubility (25°C) In vitro DMSO: 32 mg/mL (197.34 mM); |
|---|---|
| Melt Point(°C) | 163-165°C |
| 1. Shuai-Nan Zhang, Qi Liu, Xu-Zhao Li, Wu-De Yang, Ying Zhou. (2023) Sophora tonkinensis and active compounds inhibit mitochondrial impairments, inflammation, and LDLR deficiency in myocardial ischemia mice through regulating the vesicle-mediated transport pathway. FITOTERAPIA, [PMID:38007052] [10.1016/j.fitote.2023.105756] |
| 2. Ruizhen Li, Wanzhen Yuan, Yu Hu, Yonggang Zeng. (2023) Photoelectrochemical aptasensor for sensitively detecting S-Propranolol based on Au NPs modified g-C3N4/BiPO4 heterojunction. SENSORS AND ACTUATORS A-PHYSICAL, [PMID:] [10.1016/j.sna.2023.114737] |
| 3. Hengye Li, Xingwei Han, Lin Zhang, Wenjie Yu, Wenwen Bie, Meijie Wei, Zhongxia Wang, Fenying Kong, Wei Wang. (2023) Sulfonated polyhedral oligomeric silsesquioxane-cyclodextrin hybrid polymers for efficient removal of micropollutants from water. CARBOHYDRATE POLYMERS, [PMID:37059548] [10.1016/j.carbpol.2023.120832] |
| 4. Haibo You, Ben Chen, Liqun Fang, Tingting Lin, Ping Xu, Chu Chu, Shengqiang Tong. (2022) Analytical enantioseparation of N-alkyl drugs by reversed-phase liquid chromatography with carboxymethyl-β-cyclodextrin as mobile phase additive. CHIRALITY, 35 (1): (58-66). [PMID:36345792] [10.1002/chir.23516] |
| 5. Xin Liu, Peng Xu, Shiqi Xie, Lei Wang, Zhuoyu Yang, Pengfei Zhu, Jingwei Ma, Qiulai He, John C. Crittenden. (2022) Multiple reinforcement of chloride ion on oxidizing acetaminophen with zero-valent copper particles: In-site formation and catalysis of hydrogen peroxide. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2022.138689] |
| 6. Xin Liu, Peng Xu, Zhuoyu Yang, Pengfei Zhu, Lei Wang, Shiqi Xie. (2022) Catalytic oxidation of 4-acetamidophenol with Fe3+-enhanced Cu0 particles: In-site generation and activation of hydrogen peroxide. JOURNAL OF HAZARDOUS MATERIALS, [PMID:35739796] [10.1016/j.jhazmat.2022.129291] |
| 7. Jia Wen, Xiuge Gao, Qian Zhang, Benazir Sahito, Hongbin Si, Gonghe Li, Qi Ding, Wenda Wu, Eugenie Nepovimova, Shanxiang Jiang, Liping Wang, Kamil Kuca, Dawei Guo. (2021) Optimization of Tilmicosin-Loaded Nanostructured Lipid Carriers Using Orthogonal Design for Overcoming Oral Administration Obstacle. Pharmaceutics, 13 (3): (303). [PMID:33669090] [10.3390/pharmaceutics13030303] |
| 8. Yiqun Chen, Yang Tong, Yingwen Xue, Zizheng Liu, Min Tang, Li-Zhi Huang, Senlin Shao, Zheng Fang. (2019) Degradation of the β-blocker propranolol by sulfite activation using FeS. CHEMICAL ENGINEERING JOURNAL, [PMID:] [10.1016/j.cej.2019.123884] |
| 9. Hui Xu, Zijie Feng, Yingxiang Du. (2019) Synthesis, application and molecular modeling study of ionic liquid functionalized lactobionic acid, 3-methyl-1-(3-sulfopropyl)-1H-imidazol-3-ium lactobionate, as a chiral selector in capillary electrophoresis. ANALYST, 145 (3): (1025-1032). [PMID:31832629] [10.1039/C9AN02009H] |
| 10. Qian Zhang, Haifeng Yang, Benazir Sahito, Xinyu Li, Lin Peng, Xiuge Gao, Hui Ji, Liping Wang, Shanxiang Jiang, Dawei Guo. (2019) Nanostructured lipid carriers with exceptional gastrointestinal stability and inhibition of P-gp efflux for improved oral delivery of tilmicosin. COLLOIDS AND SURFACES B-BIOINTERFACES, [PMID:31767412] [10.1016/j.colsurfb.2019.110649] |
| 11. Xiaofei Ma, Zigui Kan, Yingxiang Du, Jiangxia Yang, Zijie Feng, Xinqi Zhu, Cheng Chen. (2019) Enantioseparation of amino alcohol drugs by nonaqueous capillary electrophoresis with a maltobionic acid-based ionic liquid as the chiral selector. ANALYST, 144 (24): (7468-7477). [PMID:31710318] [10.1039/C9AN01162E] |
| 12. Yuehua Deng, Yani Li, Wenjie Nie, Xiang Gao, Shentan Liu, Xiaochun Tan, Mingming Chen, Dongzhuang Hou. (2019) New Insights into the Interaction between Graphene Oxide and Beta-Blockers. Nanomaterials, 9 (10): (1429). [PMID:31600918] [10.3390/nano9101429] |
| 13. Liqi Dong, Youshan Zhang, Xuemin Duan, Xiaofei Zhu, Hui Sun, Jingkun Xu. (2017) Chiral PEDOT-Based Enantioselective Electrode Modification Material for Chiral Electrochemical Sensing: Mechanism and Model of Chiral Recognition. ANALYTICAL CHEMISTRY, [PMID:28809103] [10.1021/acs.analchem.7b01095] |
| 14. Xiaofei Ma, Zhenyu Fan, Zhiyuan Tang, Liangliang Cai. (2024) Investigation on improvement of enantioseparation based on clindamycin phosphate by chiral deep eutectic solvents in capillary electrophoresis. JOURNAL OF SEPARATION SCIENCE, 47 (3): (2300847). [PMID:38356235] [10.1002/jssc.202300847] |
| 15. Kaixue Zhang, Guoqing Luan, Jin Zhang, Shilong Wang, Min Jiang, Gang Bai. (2025) Ligustilide covalently binds to Cys254 of the creatine kinase, M-type protein, ameliorating acute myocardial ischemia by enhancing the creatine phosphate level. PHYTOMEDICINE, [PMID:40007343] [10.1016/j.phymed.2025.156532] |
| 16. Wenzhe Sun, Hongwei Lu, Pengqin Zhang, Lian Zeng, Bing Ye, Yi Xu, Jianan Chen, Peiran Xue, Jialin Yu, Kaifang Chen, Bin Wu, Xiao Lv, Xiaodong Guo, Yanzhen Qu. (2024) Localized propranolol delivery from a copper-loaded hydrogel for enhancing infected burn wound healing via adrenergic β-receptor blockade. Materials Today Bio, [PMID:39896979] [10.1016/j.mtbio.2024.101417] |
| 17. Zhaoqing Xi, Ling Shu, Lingling Xiao, Xuesheng Fang, Mingyan Dai, Jing Wang, Yuan Wu, Junxia Zhang, Mingwei Bao. (2024) Macrophage NLRP3 inflammasome mediates the effects of sympathetic nerve on cardiac remodeling in obese rats. MOLECULAR AND CELLULAR ENDOCRINOLOGY, [PMID:39557185] [10.1016/j.mce.2024.112417] |
| 18. Zhiqin Liu, Yufeng Xu, Wei Liu, Lin Wang, Zhen Dong, Jianguo Zeng. (2025) Macleaya cordata protopine total alkaloids as potential treatment for diarrhoea: Mechanistic insights and target identification. RESEARCH IN VETERINARY SCIENCE, [PMID:40184723] [10.1016/j.rvsc.2025.105633] |
| 19. Tongfei Gao, Zhuangzhuang Dong, Jianhua Xiong, Hongxia Hao, Xiantao Shen, Wenge Tang, Zhen Tong, Chuixiu Huang. (2026) Liquid-Phase Microextraction Assisted Surface-Enhanced Raman Spectroscopy: On-site Quantification of Amphetamine-Type Stimulants in Complex Samples from Crime Scenes. ANALYTICA CHIMICA ACTA, [PMID:] [10.1016/j.aca.2026.345427] |
